Search Results - "Wyper, David J"

In vivo [123I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats by Knol, Remco J.J., De Bruin, Kora, Van Eck-Smit, Berthe L.F., Pimlott, Sally, Wyper, David J., Booij, Jan

“…Disturbances of activity of the glutamatergic neurotransmitter system in the brain are present in many neuropsychiatric disorders. The N‐methyl‐D‐aspartate…”
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Cholinergic and perfusion brain networks in Parkinson disease dementia by Colloby, Sean J, McKeith, Ian G, Burn, David J, Wyper, David J, OʼBrien, John T, Taylor, John-Paul

“…OBJECTIVE:To investigate muscarinic M1/M4 cholinergic networks in Parkinson disease dementia (PDD) and their association with changes in Mini-Mental State…”
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A spatial covariance 123 I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease by Colloby, Sean J, Field, Robert H, Wyper, David J, O'Brien, John T, Taylor, John-Paul

“…Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these…”
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A spatial covariance 123I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease by Colloby, Sean J., Field, Robert H., Wyper, David J., O'Brien, John T., Taylor, John-Paul

“…Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these…”
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Regional covariance of muscarinic acetylcholine receptors in Alzheimer’s disease using (R, R) [123I]-QNB SPECT by Colloby, Sean J., McKeith, Ian G., Wyper, David J., O’Brien, John T., Taylor, John-Paul

“…Alzheimer’s disease (AD) is characterised by deficits in cholinergic neurotransmission and subsequent receptor changes. We investigated 123…”
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5-(123)I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment by Terrière, Emma, Dempsey, Mary F, Herrmann, Lucie L, Tierney, Kevin M, Lonie, Jane A, O'Carroll, Ronan E, Pimlott, Sally, Wyper, David J, Herholz, Karl, Ebmeier, Klaus P

“…Treatments currently licensed for Alzheimer's dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of…”
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Nicotinic 123I-5IA-85380 Single Photon Emission Computed Tomography as a Predictor of Cognitive Progression in Alzheimer's Disease and Dementia With Lewy Bodies by Colloby, Sean J., Perry, Elaine K., Pakrasi, Sanjeet, Pimlott, Sally L., Wyper, David J., McKeith, Ian G., Williams, E David, O'Brien, John T.

“…To investigate normalized 123I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) single photon emission computed tomography (SPECT) imaging, a marker…”
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Rapid and efficient radiosynthesis of [123 I]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors by Pimlott, Sally L, Stevenson, Louise, Wyper, David J, Sutherland, Andrew

“…Abstract Introduction [123 I]I-PK11195 is a high-affinity single photon emission computed tomography radiotracer for peripheral benzodiazepine receptors that…”
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5- 123I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment by Terrière, Emma, Dempsey, Mary F., Herrmann, Lucie L., Tierney, Kevin M., Lonie, Jane A., O’Carroll, Ronan E., Pimlott, Sally, Wyper, David J., Herholz, Karl, Ebmeier, Klaus P.

“…Treatments currently licensed for Alzheimer's dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of…”
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Effects of level of retrieval success on recall-related frontal and medial temporal lobe activations by Montaldi, D, Mayes, A R, Barnes, A, Hadley, D M, Patterson, J, Wyper, D J

“…Brain dedicated single photon emission computed tomography (SPECT) was used to compare the neuroactivation produced by the cued recall of response words in a…”
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SPECT Imaging in Head Injury Interpreted with Statistical Parametric Mapping by Stamatakis, Emmanuel A, Wilson, J. T. Lindsay, Hadley, Donald M, Wyper, David J

“…This study investigated regional cerebral blood flow in head-injured patients using statistical parametric mapping (SPM) to detect hypoperfusion on…”
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The effect of specific anti-inflammatory treatment on the serotonin transporter by Wyper, David J., Paterson, C., Patterson, J., Pimlott, S., McInnes, I.B., Cavanagh, J.

“…Tumor necrosis factor alpha (TNF-[alpha]) is a pro-inflammatory cytokine involved in the pathogenesis of rheumatoid arthritis. Methods Six patients with…”
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SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380 by Pimlott, Sally L., Piggott, Margaret, Patterson, James, Cavanagh, Jonathan, Wyper, David J.

“…In order to image nAChR density in vivo in humans, [5‐123I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐123I]A85380) has been developed as a SPECT imaging…”
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In vivo SPECT imaging of muscarinic acetylcholine receptors using ( R, R) 123I-QNB in dementia with Lewy bodies and Parkinson’s disease dementia by Colloby, Sean J., Pakrasi, Sanjeet, Firbank, Michael J., Perry, Elaine K., Piggott, Margaret A., Owens, Jonathan, Wyper, David J., McKeith, Ian G., Burn, David J., Williams, E. David, O’Brien, John T.

“…Alterations in cholinergic function have been reported to be associated with dementia. The aim of this study was to investigate differences in the distribution…”
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Focal cerebral hyperemia after focal head injury in humans : a benign phenomenon ? by SAKAS, D. E, BULLOCK, R, PATTERSON, J, HADLEY, D, WYPER, D. J, TEASDALE, G. M

“…To assess the relationship between posttraumatic cerebral hyperemia and focal cerebral damage, the authors performed cerebral blood flow mapping studies by…”
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A spatial covariance123 I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer’s disease by Colloby, Sean J, Field, Robert H, Wyper, David J, O’Brien, John T, Taylor, John-Paul

“…Abstract Alzheimer’s disease (AD) is characterised by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern…”
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Correlation of Parkinson's disease severity and duration with123I-FP-CIT SPECT striatal uptake by Benamer, Hani T. S., Patterson, Jim, Wyper, David J., Hadley, Donald M., Macphee, G. J. A., Grosset, Donald G.

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Applications of SPECT in cognitive neuroscience, neurology and psychiatry by Wyper, D J, Montaldi, D

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Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake by Benamer, Hani T. S., Patterson, Jim, Wyper, David J., Hadley, Donald M., Macphee, G. J. A., Grosset, Donald G.

“…The variability in clinical features and the masking effects of drug therapy in Parkinson's disease (PD) can affect clinical assessment of disease severity…”
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123Iodo-MK-801: A spect agent for imaging the pattern and extent of glutamate (NMDA) receptor activation in Alzheimer's disease by Brown, Derek R.P., Wyper, David J., Owens, Jonathan, Patterson, James, Kelly, R. Ciara, Hunter, Robert, McCulloch, James

“…Glutamate, and the NMDA glutamate receptor, may be involved in Alzheimer's Disease (AD). Reductions in NMDA receptors are found in AD, possibly contributing to…”
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