Search Results - "Wynne, Abigail"

Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner by Hausenloy, Derek J, Whittington, Hannah J, Wynne, Abigail M, Begum, Shah S, Theodorou, Louise, Riksen, Niels, Mocanu, Mihaela M, Yellon, Derek M

“…The dipeptidyl peptidase-4 (DPP-4) inhibitors Sitagliptin and Vildagliptin lower blood glucose by augmenting endogenous levels of glucagon-like peptide-1…”
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Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection by HAUSENLOY, Derek, WYNNE, Abigail, DUCHEN, Michael, YELLON, Derek

“…Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial…”
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Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening by Bhamra, Gurpreet S., Hausenloy, Derek J., Davidson, Sean M., Carr, Richard D., Paiva, Marta, Wynne, Abigail M., Mocanu, Mihaela M., Yellon, Derek M.

“…Background In the majority of studies, metformin has been demonstrated to cardioprotect diabetic patients, the mechanism of which is unclear. We hypothesized…”
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Preconditioning the diabetic human myocardium by Sivaraman, Vivek, Hausenloy, Derek J., Wynne, Abigail M., Yellon, Derek M.

“…Our objective was to determine whether human diabetic myocardium is amenable to the cardioprotective actions of ischaemic preconditioning. Human right atrial…”
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Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore by Smith, Christopher C T, Dixon, Richard A, Wynne, Abigail M, Theodorou, Louise, Ong, Sang-Ging, Subrayan, Sapna, Davidson, Sean M, Hausenloy, Derek J, Yellon, Derek M

“…Leptin-induced protection against myocardial ischemia-reperfusion (I/R) injury involves the activation of the reperfusion injury salvage kinase pathway,…”
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Ischemic preconditioning targets the reperfusion phase by Hausenloy, Derek J, Wynne, Abigail M, Yellon, Derek M

“…Emerging studies suggest that signaling during the myocardial reperfusion phase contributes to ischemic preconditioning (IPC). Whether the activation of PKC,…”
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Glimepiride treatment facilitates ischemic preconditioning in the diabetic heart by Hausenloy, Derek J, Wynne, Abigail M, Mocanu, Mihaela M, Yellon, Derek M

“…The diabetic heart is resistant to the myocardial infarct-limiting effects of ischemic preconditioning (IPC). This may be in part due to the downregulation of…”
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Pioglitazone Mimics Preconditioning in the Isolated Perfused Rat Heart: A Role for the Prosurvival Kinases PI3K and P42/44MAPK by Wynne, Abigail M, Mocanu, Mihaela M, Yellon, Derek M

“…Ischemic preconditioning, the most powerful protection against infarction, activates PI3Kinase (PI3K)/AKT and P42/44MAPK. Pioglitazone, a thiazolidinedione and…”
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Reperfusion signaling in preconditioned hearts: Role for Pkc, The Mkatp channel, oxidative stress and transient acidosis by Wynne, Abigail M, Hausenloy, Derek

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The Cardioprotective Actions of Leptin Are Lost in the Zucker Obese (fa/fa) Rat by Dixon, Richard A, Davidson, Sean M, Wynne, Abigail M, Yellon, Derek M, Smith, Christopher C T

“…Protection against myocardial ischemia-reperfusion injury, including that induced by leptin, involves activation of the reperfusion injury salvage kinase…”
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Temporal Changes in Myocardial Salvage Kinases During Reperfusion Following Ischemia : Studies Involving the Cardioprotective Adipocytokine Apelin by SMITH, Christopher C. T, MOCANU, Michaela M, BOWEN, Jonathan, WYNNE, Abigail M, SIMPKIN, James C, DIXON, Richard A, COOPER, Michael B, YELLON, Derek M

“…Activation of the Reperfusion Injury Salvage Kinase (RISK) pathway, which incorporates phosphatidylinositol-3-OH kinase (PI3K)-Akt/protein kinase B (PKB) and…”
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Failure of the adipocytokine, resistin, to protect the heart from ischemia-reperfusion injury by Smith, Christopher C T, Lim, Shiang Y, Wynne, Abigail M, Sivaraman, Vivek, Davidson, Sean M, Mocanu, Mihaela M, Hausenloy, Derek J, Yellon, Derek M

“…Experimental studies have linked the adipocytokines with acute cardioprotection. Whether the adipocytokine, resistin, confers protection is, however,…”
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Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury by Simpkin, J. C., Yellon, D. M., Davidson, S. M., Lim, S. Y., Wynne, A. M., Smith, C. C. T.

“…Protection against myocardial ischemia-reperfusion (I/R) injury involves activation of phosphatidylinositol-3-OH kinase (PI3K)- Akt/protein kinase B and p44/42…”
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The adipocytokine, resistin, is not cardioprotective despite activating components of the risk pathway by Lim, Shiang, Smith, Christopher, Wynne, Abigail, Sivaraman, Vivek, Davidson, Sean, Mocanu, Mihaela, Hausenloy, Derek, Yellon, Derek

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Ischaemic Preconditioning and Postconditioning do not Affect Adenosine A1 and A2A Receptor Sensitivity by Riksen, Niels P., Wynne, Abigail, Yellon, Derek M., Hausenloy, Derek J.

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Ischaemic preconditioning and postconditioning do not affect adenosine A(1) and A (2A) receptor sensitivity by Riksen, Niels P, Wynne, Abigail, Yellon, Derek M, Hausenloy, Derek J

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Over-expression of the cardioprotective kinase Akt modulates mitochondrial morphology by Hausenloy, Derek J, Davidson, Sean, Wynne, Abigail, Cipolat, Sara, Yellon, Derek M, Scorrano, Luca

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Glimepiride reduces the threshold for ischemic preconditioning in the diabetic heart by Wynne, Abigail, Hausenloy, Derek J, Mocanu, Mihaela M, Yellon, Derek M

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The metabolic syndrome raises the threshold for cardioprotection by Hausenloy, Derek J, Wynne, Abigail, Mocanu, Mihaela M, Yellon, Derek M

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Leptin, the obesity-related adipocytokine, protects the myocardium against ischaemia–reperfusion injury by Smith, Christopher C.T., Mocanu, Mihaela M., Davidson, Sean M., Wynne, Abigail, Simpkin, James, Yellon, Derek M.

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