Search Results - "Wynn, T A"

Cellular and molecular mechanisms of fibrosis by Wynn, TA

“…Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components…”
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Pulmonary fibrosis: pathogenesis, etiology and regulation by Wilson, M S, Wynn, T A

“…Pulmonary fibrosis and architectural remodeling of tissues can severely disrupt lung function, often with fatal consequences. The etiology of pulmonary…”
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Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity by Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., Bhandoola, A., Wynn, T. A., Belkaid, Y.

“…How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such as the intestine, remains unclear. Vitamin A deficiency is one of…”
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Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis by Borthwick, L A, Barron, L, Hart, K M, Vannella, K M, Thompson, R W, Oland, S, Cheever, A, Sciurba, J, Ramalingam, T R, Fisher, A J, Wynn, T A

“…The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three…”
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The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells by Meylan, F, Hawley, E T, Barron, L, Barlow, J L, Penumetcha, P, Pelletier, M, Sciumè, G, Richard, A C, Hayes, E T, Gomez-Rodriguez, J, Chen, X, Paul, W E, Wynn, T A, McKenzie, A N J, Siegel, R M

“…The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells and promotes diverse T cell-dependent models of autoimmune disease through…”
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Large strain deformation of bimodal layer thickness Cu/Nb nanolamellar composites by Wynn, T.A., Bhattacharyya, D., Hammon, D.L., Misra, A., Mara, N.A.

“…Nanolayered composites have garnered much attention due to their ability to withstand deformation to large strains, shock deformation, and irradiation induced…”
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Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of L-Arginine Metabolism by Hesse, Matthias, Modolell, Manuel, La Flamme, Anne C, Schito, Marco, Fuentes, Jose Manuel, Cheever, Allen W, Pearce, Edward J, Wynn, Thomas A

“…Type 2 cytokines regulate fibrotic liver pathology in mice infected with Schistosoma mansoni. Switching the immune response to a type 1-dominant reaction has…”
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Transforming growth factor‐β1 inhibits activation of macrophage cell line RAW 264.7 for cell killing by HAAK‐FRENDSCHO, M., WYNN, T. A., CZUPRYNSKI, C. J., PAULNOCK, D.

“…SUMMARY Transforming growth factor β‐1 (TGF‐β) is a multi‐potent immunoregulatory peptide that has effects on numerous cell types. Here we report that human…”
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Interleukin 12 is Required for the T-Lymphocyte-Independent Induction of Interferon γ by an Intracellular Parasite and Induces Resistance in T-Cell-Deficient Hosts by Gazzinelli, Ricardo T., Hieny, Sara, Wynn, Thomas A., Wolf, Stanley, Sher, Alan

“…Immunity against the intracellular protozoan Toxoplasma gondii is highly dependent on interferon γ(IFN-γ). We have previously shown that, in addition to T…”
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Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production by Rutschman, Robert, Lang, Roland, Hesse, Matthias, Ihle, James N, Wynn, Thomas A, Murray, Peter J

“…The cytokines IL-4 and IL-13 inhibit the production of NO from activated macrophages through an unresolved molecular mechanism. We show here that IL-4 and…”
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Structure and mechanical properties of swift heavy ion irradiated tungsten-bearing delta-phase oxides Y6W1O12 and Yb6W1O12 by Tang, M., Wynn, T.A., Patel, M.K., Won, J., Monnet, I., Pivin, J.C., Mara, N.A., Sickafus, K.E.

“…We report on the relationship between structure and mechanical properties of complex oxides whose structures are derivatives of fluorite, following irradiation…”
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Nucleation of dislocations and their dynamics in layered oxide cathode materials during battery charging by Singer, A., Zhang, M., Hy, S., Cela, D., Fang, C., Wynn, T. A., Qiu, B., Xia, Y., Liu, Z., Ulvestad, A., Hua, N., Wingert, J., Liu, H., Sprung, M., Zozulya, A. V., Maxey, E., Harder, R., Meng, Y. S., Shpyrko, O. G.

“…Lithium-rich layered oxides (LRLO) are among the leading candidates for the next-generation cathode material for energy storage, delivering 50% excess capacity…”
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Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology by WYNN, T. A, ISAM ELTOUM, OSWALD, I. P, CHEEVER, A. W, SHER, A

“…Morbidity in humans infected with Schistosoma mansoni results primarily from the deposition of parasite eggs in portal areas where they induce a granulomatous…”
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IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts by Suwara, M I, Green, N J, Borthwick, L A, Mann, J, Mayer-Barber, K D, Barron, L, Corris, P A, Farrow, S N, Wynn, T A, Fisher, A J, Mann, D A

“…Activation of the innate immune system plays a key role in exacerbations of chronic lung disease, yet the potential role of lung fibroblasts in innate immunity…”
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Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni by Wynn, TA, Eltoum, I, Cheever, AW, Lewis, FA, Gause, WC, Sher, A

“…Granulomas induced by parasite eggs are the primary lesions in mice infected with Schistosoma mansoni. Temporal analysis of cytokine mRNA expression in lung…”
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Interleukin 10 Inhibits Macrophage Microbicidal Activity by Blocking the Endogenous Production of Tumor Necrosis Factor α Required as a Costimulatory Factor for Interferon γ-Induced Activation by Oswald, Isabelle P., Wynn, Thomas A., Sher, Alan, James, Stephanie L.

“…Interleukin 10 (IL-10) inhibits interferon γ-induced macrophage activation for cytotoxicity against larvae of the human parasite Schistosoma mansoni by…”
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Regulation of Hepatic Fibrosis and Extracellular Matrix Genes by the Th Response: New Insight into the Role of Tissue Inhibitors of Matrix Metalloproteinases by Vaillant, Brian, Chiaramonte, Monica G, Cheever, Allen W, Soloway, Paul D, Wynn, Thomas A

“…Hepatic fibrosis is the hallmark of Schistosoma mansoni infection and often results in portal hypertension and bleeding from esophageal varices. The fibrotic…”
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IL-13 EFFECTOR FUNCTIONS by Wynn, Thomas A

“…IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class II expression, promoted IgE class switching and inhibited…”
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Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation by KULLBERG, Marika C, GIGLIOTTI ROTHFUCHS, Antonio, JANKOVIC, Dragana, CASPAR, Patricia, WYNN, Thomas A, GORELICK, Peter L, CHEEVER, Allen W, SHER, Alan

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection by Scharton-Kersten, TM, Wynn, TA, Denkers, EY, Bala, S, Grunvald, E, Hieny, S, Gazzinelli, RT, Sher, A

“…The relationship between IFN-gamma and IL-12 in generating innate immune responses and resistance to acute Toxoplasma gondii infection was assessed in T…”
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