Search Results - "Wynn, R Max"

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance by Zhou, Meiyi, Shao, Jing, Wu, Cheng-Yang, Shu, Le, Dong, Weibing, Liu, Yunxia, Chen, Mengping, Wynn, R Max, Wang, Jiqiu, Wang, Ji, Gui, Wen-Jun, Qi, Xiangbing, Lusis, Aldons J, Li, Zhaoping, Wang, Weiqing, Ning, Guang, Yang, Xia, Chuang, David T, Wang, Yibin, Sun, Haipeng

“…Recent studies implicate a strong association between elevated plasma branched-chain amino acids (BCAAs) and insulin resistance (IR). However, a causal…”
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Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure by Sun, Haipeng, Olson, Kristine C, Gao, Chen, Prosdocimo, Domenick A, Zhou, Meiyi, Wang, Zhihua, Jeyaraj, Darwin, Youn, Ji-Youn, Ren, Shuxun, Liu, Yunxia, Rau, Christoph D, Shah, Svati, Ilkayeva, Olga, Gui, Wen-Jun, William, Noelle S, Wynn, R Max, Newgard, Christopher B, Cai, Hua, Xiao, Xinshu, Chuang, David T, Schulze, Paul Christian, Lynch, Christopher, Jain, Mukesh K, Wang, Yibin

“…BACKGROUND—Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and…”
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase by White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan M., Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L., Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guo-Fang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.

“…Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood…”
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The intrinsic substrate specificity of the human tyrosine kinome by Yaron-Barir, Tomer M., Joughin, Brian A., Huntsman, Emily M., Kerelsky, Alexander, Cizin, Daniel M., Cohen, Benjamin M., Regev, Amit, Song, Junho, Vasan, Neil, Lin, Ting-Yu, Orozco, Jose M., Schoenherr, Christina, Sagum, Cari, Bedford, Mark T., Wynn, R. Max, Tso, Shih-Chia, Chuang, David T., Li, Lei, Li, Shawn S.-C., Creixell, Pau, Krismer, Konstantin, Takegami, Mina, Lee, Harin, Zhang, Bin, Lu, Jingyi, Cossentino, Ian, Landry, Sean D., Uduman, Mohamed, Blenis, John, Elemento, Olivier, Frame, Margaret C., Hornbeck, Peter V., Cantley, Lewis C., Turk, Benjamin E., Yaffe, Michael B., Johnson, Jared L.

“…Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth 1 . Multicellular eukaryotes…”
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Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure by Chen, Mengping, Gao, Chen, Yu, Jiayu, Ren, Shuxun, Wang, Menglong, Wynn, R Max, Chuang, David T, Wang, Yibin, Sun, Haipeng

“…Background Branched-chain amino acid (BCAA) catabolic defect is an emerging metabolic hallmark in failing hearts in human and animal models. The therapeutic…”
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A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity by Wu, Cheng-Yang, Satapati, Santhosh, Gui, Wenjun, Wynn, R. Max, Sharma, Gaurav, Lou, Mingliang, Qi, Xiangbing, Burgess, Shawn C., Malloy, Craig, Khemtong, Chalermchai, Sherry, A. Dean, Chuang, David T., Merritt, Matthew E.

“…The pyruvate dehydrogenase complex (PDC) is a key control point of energy metabolism and is subject to regulation by multiple mechanisms, including…”
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In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma by Suh, Eul Hyun, Hackett, Edward P., Wynn, R. Max, Chuang, David T., Zhang, Bo, Luo, Weibo, Sherry, A. Dean, Park, Jae Mo

“…Altered branched-chain amino acids (BCAAs) metabolism is a distinctive feature of various cancers and plays an important role in sustaining tumor proliferation…”
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Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket by Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Wu, Cheng-Yang, Chuang, Jacinta L., Wernstedt-Asterholm, Ingrid, Morlock, Lorraine K., Owens, Kyle R., Scherer, Philipp E., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.

“…Pyruvate dehydrogenase kinase isoforms (PDKs 1–4) negatively regulate activity of the mitochondrial pyruvate dehydrogenase complex by reversible…”
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Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops by Kato, Masato, Wynn, R. Max, Chuang, Jacinta L., Tso, Shih-Chia, Machius, Mischa, Li, Jun, Chuang, David T.

“…We report the crystal structures of the phosporylated pyruvate dehydrogenase (E1p) component of the human pyruvate dehydrogenase complex (PDC). The complete…”
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Importin-α Protein Binding to a Nuclear Localization Signal of Carbohydrate Response Element-Binding Protein (ChREBP) by Ge, Qiang, Nakagawa, Tsutomu, Wynn, R. Max, Chook, Yuh Min, Miller, Bonnie C., Uyeda, Kosaku

“…Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in the glucose-mediated…”
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Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase by Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Chuang, Jacinta L., Morlock, Lorraine K., Wallace, Amy L., Ahmed, Kamran, Laxman, Sunil, Campeau, Philippe M., Lee, Brendan H., Hutson, Susan M., Tu, Benjamin P., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.

“…The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes…”
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Subunit and Catalytic Component Stoichiometries of an in Vitro Reconstituted Human Pyruvate Dehydrogenase Complex by Brautigam, Chad A., Wynn, R. Max, Chuang, Jacinta L., Chuang, David T.

“…The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton catalytic machine that employs three catalytic components, i.e. pyruvate dehydrogenase…”
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Lessons from genetic disorders of branched-chain amino acid metabolism by Chuang, David T, Chuang, Jacinta L, Wynn, R Max

“…Genetic disorders of BCAA metabolism produce amino acidopathies and various forms of organic aciduria with severe clinical consequences. A metabolic block in…”
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Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site by Fukasawa, Masashi, Ge, Qing, Wynn, R. Max, Ishii, Seiji, Uyeda, Kosaku

“…Carbohydrate response element binding protein (ChREBP) is responsible for conversion of dietary carbohydrate to storage fat in liver by coordinating expression…”
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GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules by Wei, Jen-Hsuan, Zhang, Zi Chao, Wynn, R. Max, Seemann, Joachim

“…Spindle assembly requires the coordinated action of multiple cellular structures to nucleate and organize microtubules in a precise spatiotemporal manner…”
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Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice by Wu, Cheng-Yang, Tso, Shih-Chia, Chuang, Jacinta L., Gui, Wen-Jun, Lou, Mingliang, Sharma, Gaurav, Khemtong, Chalermchai, Qi, Xiangbing, Wynn, R. Max, Chuang, David T.

“…Mitochondrial pyruvate dehydrogenase kinases 1–4 (PDKs1–4) negatively regulate activity of the pyruvate dehydrogenase complex (PDC) by reversible…”
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Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity by Wynn, R. Max, Kato, Masato, Chuang, Jacinta L., Tso, Shih-Chia, Li, Jun, Chuang, David T.

“…Human pyruvate dehydrogenase complex (PDC) is down-regulated by pyruvate dehydrogenase kinase (PDK) isoforms 1–4. PDK4 is overexpressed in skeletal muscle in…”
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Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): role of ketone bodies by Nakagawa, Tsutomu, Ge, Qiang, Pawlosky, Robert, Wynn, R Max, Veech, Richard L, Uyeda, Kosaku

“…The carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in converting excess…”
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Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex by Kato, Masato, Chuang, Jacinta L, Tso, Shih-Chia, Wynn, R Max, Chuang, David T

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Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR by Sato, Shogo, Jung, Hunmin, Nakagawa, Tsutomu, Pawlosky, Robert, Takeshima, Tomomi, Lee, Wan-Ru, Sakiyama, Haruhiko, Laxman, Sunil, Wynn, R Max, Tu, Benjamin P, MacMillan, John B, De Brabander, Jef K, Veech, Richard L, Uyeda, Kosaku

“…The carbohydrate-response element-binding protein (ChREBP) is a glucose-responsive transcription factor that plays an essential role in converting excess…”
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