Search Results - "Wynn, R F"

Changes in the incidence, patterns and outcomes of graft failure following hematopoietic stem cell transplantation for Hurler syndrome by Lum, S H, Miller, W P, Jones, S, Poulton, K, Ogden, W, Lee, H, Logan, A, Bonney, D, Lund, T C, Orchard, P J, Wynn, R F

“…Hematopoietic stem cell transplantation (HSCT) is the standard of care in children with Hurler syndrome (HS) as it is the only therapy that can arrest disease…”
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Outcomes of hematopoietic stem cell transplantation for Hurler's syndrome in Europe: a risk factor analysis for graft failure by BOELENS, J. J, WYNN, R. F, SEDLACEK, P, ROVELLI, A, UITERWAAL, C. S. P. M, WULFFRAAT, N, O'MEARA, A, VEYS, P, BERTRAND, Y, SOUILLET, G, WRAITH, J. E, FISCHER, A, CAVAZZANA-CALVO, M, SYKORA, K. W

“…Hurler's syndrome (HS), the most severe form of mucopolysaccharidosis type-I, causes progressive deterioration of the central nervous system and death in…”
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The anaesthetic management of children with anterior mediastinal masses by Hack, H. A., Wright, N. B., Wynn, R. F.

“…Summary Children with anterior mediastinal masses may experience serious complications during general anaesthesia. We retrospectively surveyed the records of…”
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Chronic norovirus infection in pediatric hematopoietic stem cell transplant recipients: A cause of prolonged intestinal failure requiring intensive nutritional support by Saif, M. A., Bonney, D. K., Bigger, B., Forsythe, L., Williams, N., Page, J., Babiker, Z. O., Guiver, M., Turner, A. J., Hughes, S., Wynn, R. F.

“…Saif MA, Bonney DK, Bigger B, Forsythe L, Williams N, Page J, Babiker ZO, Guiver M, Turner AJ, Hughes S, Wynn RF. Chronic norovirus infection in pediatric…”
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Haematopoietic cell transplantation (HCT) in combination with enzyme replacement therapy (ERT) in patients with Hurler syndrome by COX-BRINKMAN, J, BOELENS, J.-J, WRAITH, J. E, O'MEARA, A, VEYS, P, WIJBURG, F. A, WULFFRAAT, N, WYNN, R. F

“…Hurler syndrome (MPS 1H) is the severe form of mucopolysaccharidosis type 1 (MPS 1). Haematopoietic cell transplantation (HCT) is the treatment of choice, but…”
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Biochemical monitoring after haemopoietic stem cell transplant for Hurler syndrome (MPSIH): implications for functional outcome after transplant in metabolic disease by CHURCH, H, TYLEE, K, COOPER, A, THORNLEY, M, MERCER, J, WRAITH, E, CARR, T, O'MEARA, A, WYNN, R. F

“…Hurler Syndrome is corrected by allogeneic BMT by the action of donor enzyme on recipient tissue. In this paper, we describe monitoring of 39 patients…”
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Multifocal vascular lesions and thrombocytopenia in a 10-year-old boy: retrospective review of a recently recognized rare congenital disorder by Madan, V., Jamieson, L., F Wynn, R., Shabani, A., Judge, M. R.

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Systemic juvenile idiopathic arthritis, Kikuchi's disease and haemophagocytic lymphohistiocytosis—is there a link? Case report and literature review by Ramanan, A. V., Wynn, R. F., Kelsey, A., Baildam, E. M.

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Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia by Kerr, J R, Barah, F, Cunniffe, V S, Smith, J, Vallely, P J, Will, A M, Wynn, R F, Stevens, R F, Taylor, G M, Cleator, G M, Eden, O B

“…Aims: To investigate the association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia. Methods: Cerebrospinal…”
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Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants by Wynn, Robert F, Cross, Michael A, Hatton, Claire, Will, Andrew M, Lashford, Linda S, Dexter, T Michael, Testa, Nydia G

“…The establishment of donor-derived haemopoiesis in the recipients of allogeneic bone-marrow transplants (BMT) involves extensive proliferation of haemopoietic…”
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Marrow stromal cells from patients affected by MPS I differentially support haematopoietic progenitor cell development by Baxter, M. A., Wynn, R. F., Schyma, L., Holmes, D. K., Wraith, J. E., Fairbairn, L. J., Bellantuono, I.

“…Summary Bone marrow transplantation is the therapy of choice in patients affected by MPS I (Hurler syndrome), but a high incidence of rejection limits the…”
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Effects of topoisomerase 2 inhibitors on the MLL gene in children receiving chemotherapy: a prospective study by NG, A, TAYLOR, G. M, WYNN, R. F, EDEN, O. B

“…The molecular effects of etoposide in haemopoietic cells suggest that mixed lineage leukaemia (MLL) abnormalities can be biomarkers of patient susceptibility…”
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CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation by Martin, Emmanuel, Palmic, Noé, Sanquer, Sylvia, Lenoir, Christelle, Hauck, Fabian, Mongellaz, Cédric, Fabrega, Sylvie, Nitschké, Patrick, Esposti, Mauro Degli, Schwartzentruber, Jeremy, Taylor, Naomi, Majewski, Jacek, Jabado, Nada, Wynn, Robert F., Picard, Capucine, Fischer, Alain, Arkwright, Peter D., Latour, Sylvain

“…Loss-of-function mutations in the human CTP synthase 1 gene cause an immunodeficiency disease with impaired T cell proliferation after antigen stimulation,…”
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G542(P) Comparing fertility outcomes in paediatric patients treated with busulfan or treosulfan prior to haematopoietic stem cell transplant by Prathivadi Bhayankaram, N, Fitzgerald, CT, Wynn, RF

“…BackgroundHaematopoietic stem cell transplant (HCT) can be used to treat malignant and non-malignant conditions. Prior to HCT, patients have conditioning with…”
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Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis by NG, A, RAVETTO, P. F, TAYLOR, G. M, WYNN, R. F, EDEN, O. B

“…Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed…”
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Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation by Wynn, R F, Sood, M, Theilgaard-Mönch, K, Jones, C J, Gombart, A F, Gharib, M, Koeffler, H P, Borregaard, N, Arkwright, P D

“…Over the following months she developed a number of pyogenic subcutaneous abscesses as well as septicaemia. Because of the constellation of clinical features,…”
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Hematopoietic stem cell transplantation improves the high incidence of neutralizing allo-antibodies observed in Hurler’s syndrome after pharmacological enzyme replacement therapy by AMEER SAIF, Muhammad, BIGGER, Brian W, BROOKES, Karen E, MERCER, Jean, TYLEE, Karen L, CHURCH, Heather J, BONNEY, Denise K, JONES, Simon, ED WRAITH, J, WYNN, Robert F

“…Mucopolysaccharidosis type I is caused by deficiency of α-L-iduronidase. Currently available treatment options include an allogeneic hematopoietic stem cell…”
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Prominent dyserythropoiesis in four cases of haemophagocytic lymphohistiocytosis by Macheta, M, Will, A M, Houghton, J B, Wynn, R F

“…Haemophagocytic lymphohistiocytosis (HLH) is a disease characterised by peripheral blood pancytopenia secondary to haemophagocytosis of formed blood cells by…”
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Developmental outcome post allogenic bone marrow transplant for Niemann Pick Type C2 by Breen, C., Wynn, R.F., O'Meara, A., O'Mahony, E., Rust, S., Imrie, J., Wraith, J.E.

“…Niemann Pick Type C2 (NPC2) is a rare autosomal recessive disease caused by mutations in the NPC2 gene (OMIM 601015). Clinically, NPC2 presents in most cases…”
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G408(P) Cytokine storm associated multi-organ failure with poor neurological outcome, during rituximab administration in a child with relapsed acute lymphoblastic leukaemia and ebv related lymphoproliferative disease by Kanaris, C, Wynn, RF, Konstantinidis, A

“…We present the case of a 6 year old boy, with relapsed Acute Lymphoblastic Leukaemia and subsequent matched unrelated bone marrow transplant. His Epstein Barr…”
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