Search Results - "Wynn, Michelle"

The importance of accurately correcting for the natural abundance of stable isotopes by Midani, Firas S., Wynn, Michelle L., Schnell, Santiago

“…The use of isotopically labeled tracer substrates is an experimental approach for measuring in vivo and in vitro intracellular metabolic dynamics. Stable…”
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Changes in maternal pregnane concentrations in mares with experimentally-induced, ascending placentitis by Wynn, Michelle A.A., Ball, Barry A., May, John, Esteller-Vico, Alejandro, Canisso, Igor, Squires, Edward, Troedsson, Mats

“…The objectives of this study were to compare via liquid chromatography-tandem mass spectrometry (LC-MS/MS) progesterone (P4), 5α-dihydroprogesterone (DHP),…”
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Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovary by Shrestha, Ketan, Al-Alem, Linah, Garcia, Priscilla, Wynn, Michelle A. A., Hannon, Patrick R., Jo, Misung, Drnevich, Jenny, Duffy, Diane M., Curry, Thomas E.

“…The luteinizing hormone (LH) surge induces paracrine mediators within the ovarian follicle that promote ovulation. The present study explores neurotensin…”
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Logic-based models in systems biology: a predictive and parameter-free network analysis method by Wynn, Michelle L, Consul, Nikita, Merajver, Sofia D, Schnell, Santiago

“…Highly complex molecular networks, which play fundamental roles in almost all cellular processes, are known to be dysregulated in a number of diseases, most…”
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A comparison of progesterone assays for determination of peripheral pregnane concentrations in the late pregnant mare by Wynn, Michelle A.A., Esteller-Vico, Alejandro, Legacki, Erin L., Conley, Alan J., Loux, Shavahn C., Stanley, Scott D., Curry, Thomas E., Squires, Edward L., Troedsson, Mats H., Ball, Barry A.

“…During the latter half of gestation in mares, there is a complex milieu of pregnanes in peripheral blood. Progesterone concentrations are often assessed by…”
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Inhibition of 5α-reductase alters pregnane metabolism in the late pregnant mare by Wynn, Michelle A A, Ball, Barry A, Legacki, Erin, Conley, Alan, Loux, Shavahn, May, John, Esteller-Vico, Alejandro, Stanley, Scott, Scoggin, Kirsten, Squires, Edward, Troedsson, Mats

“…In the latter half of gestation in the mare, progesterone concentrations decline to near undetectable levels while other 5α-reduced pregnanes are elevated. Of…”
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Protease expression in the human and rat cumulus-oocyte complex during the periovulatory period: a role in cumulus-oocyte complex migration by Shrestha, Ketan, Puttabyatappa, Muraly, Wynn, Michelle A, Hannon, Patrick R, Al-Alem, Linah F, Rosewell, Katherine L, Akin, James, Curry, Jr, Thomas E

“…The migratory and matrix-invading capacities of the cumulus-oocyte complex have been shown to be important for the ovulatory process. In metastatic cancers,…”
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Alterations of Circulating Biomarkers During Late Term Pregnancy Complications in the Horse Part II: Steroid Hormones and Alpha-Fetoprotein by Fedorka, Carleigh E., Ball, Barry A., Wynn, Michelle A.A., McCormick, Meghan E., Scoggin, Kirsten E., Esteller-Vico, Alejandro, Curry, Thomas E., Kennedy, Laura A., Squires, Edward L., Troedsson, Mats H.T.

“…•Ascending placentitis was associated with elevated progesterone and AFP.•Ascending placentitis was associated with decreasing estradiol-17b and E2:P4.•Focal…”
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RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells by Wynn, Michelle L., Yates, Joel A., Evans, Charles R., Van Wassenhove, Lauren D., Wu, Zhi Fen, Bridges, Sydney, Bao, Liwei, Fournier, Chelsea, Ashrafzadeh, Sepideh, Merrins, Matthew J., Satin, Leslie S., Schnell, Santiago, Burant, Charles F., Merajver, Sofia D.

“…Inflammatory breast cancer (IBC) is an extremely lethal cancer that rapidly metastasizes. Although the molecular attributes of IBC have been described, little…”
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Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour by Wynn, Michelle L., Kulesa, Paul M., Schnell, Santiago

“…Follow-the-leader chain migration is a striking cell migratory behaviour observed during vertebrate development, adult neurogenesis and cancer metastasis…”
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The Impact of Nathan Mantel's "The Detection of Disease Clustering and a Generalized Regression Approach" by Wynn, Michelle, Kidwell, Kelley M, Merajver, Sofia D

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Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments by Wynn, Michelle L., Egbert, Megan, Consul, Nikita, Chang, Jungsoo, Wu, Zhi-Fen, Meravjer, Sofia D., Schnell, Santiago

“…The development of network inference methodologies that accurately predict connectivity in dysregulated pathways may enable the rational selection of patient…”
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Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer by Meyer, Kevin A, Neeley, Christopher K, Baker, Nicki A, Washabaugh, Alexandra R, Flesher, Carmen G, Nelson, Barbara S, Frankel, Timothy L, Lumeng, Carey N, Lyssiotis, Costas A, Wynn, Michelle L, Rhim, Andrew D, O'Rourke, Robert W

“…Adipocytes promote progression of multiple cancers, but their role in pancreatic intraepithelial neoplasia (PanIN) and ductal adenocarcinoma (PDAC) is poorly…”
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Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity by Wynn, Michelle L, Ventura, Alejandra C, Sepulchre, Jacques A, García, Héctor J, Merajver, Sofia D

“…It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a…”
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Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals by Wynn, Michelle L, Rupp, Paul, Trainor, Paul A, Schnell, Santiago, Kulesa, Paul M

“…Directed cell migration often involves at least two types of cell motility that include multicellular streaming and chain migration. However, what is unclear…”
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Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells by Wynn, Michelle L., Consul, Nikita, Merajver, Sofia D., Schnell, Santiago

“…In a tumor cell, the development of acquired therapeutic resistance and the ability to survive in extracellular environments that differ from the primary site…”
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Temporal patterns of conditions and symptoms potentially associated with ovarian cancer by Wynn, Michelle L, Chang, Stella, Peipins, Lucy A

“…The late stage at which ovarian cancer is typically diagnosed and its subsequent high mortality have been attributed to a lack of symptoms in its early stages…”
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Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy by Tani, Hiroaki, Bandrowski, Anita E, Parada, Isabel, Wynn, Michelle, Huguenard, John R, Prince, David A, Reimer, Richard J

“…Abstract Epileptic activity arises from an imbalance in excitatory and inhibitory synaptic transmission. To determine if alterations in the metabolism of…”
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Unraveling the complex regulatory relationships between metabolism and signal transduction in cancer by Wynn, Michelle L, Merajver, Sofia D, Schnell, Santiago

“…Cancer cells exhibit an altered metabolic phenotype, known as the Warburg effect, which is characterized by high rates of glucose uptake and glycolysis, even…”
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Inferring the effects of honokiol on the notch signaling pathway in SW480 colon cancer cells by Wynn, Michelle L, Consul, Nikita, Merajver, Sofia D, Schnell, Santiago

“…In a tumor cell, the development of acquired therapeutic resistance and the ability to survive in extracellular environments that differ from the primary site…”
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