Search Results - "Wynn, Katherine K."

The impact of HLA‐B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV by Burrows, Jacqueline M., Wynn, Katherine K., Tynan, Fleur E., Archbold, Julia, Miles, John J., Bell, Melissa J., Brennan, Rebekah M., Walker, Susan, McCluskey, James, Rossjohn, Jamie, Khanna, Rajiv, Burrows, Scott R.

“…The factors controlling epitope selection in the T cell response to persistent viruses are not fully understood, and we have examined this issue in the context…”
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T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion by HINDLEY, James P, JONES, Emma, PRICE, David A, AGER, Ann, GODKIN, Andrew J, GALLIMORE, Awen M, SMART, Kathryn, BRIDGEMAN, Hayley, LAUDER, Sarah N, ONDONDO, Beatrice, CUTTING, Scott, LADELL, Kristin, WYNN, Katherine K, WITHERS, David

“…The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood…”
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Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors by HINDLEY, James P, FERREIRA, Cristina, DYSON, Julian, GALLIMORE, Awen, JONES, Emma, LAUDER, Sarah N, LADELL, Kristin, WYNN, Katherine K, BETTS, Gareth J, SINGH, Yogesh, PRICE, David A, GODKIN, Andrew J

“…A significant enrichment of CD4(+)Foxp3(+) T cells (regulatory T cells, Treg) is frequently observed in murine and human carcinomas. As Tregs can limit…”
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Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition by Cole, David K, Edwards, Emily S J, Wynn, Katherine K, Clement, Mathew, Miles, John J, Ladell, Kristin, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J, Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A, Sewell, Andrew K

“…Improving T cell Ags by altering MHC anchor residues is a common strategy used to enhance peptide vaccines, but there has been little assessment of how such…”
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IL-10 restricts memory T cell inflation during cytomegalovirus infection by Jones, Morgan, Ladell, Kristin, Wynn, Katherine K, Stacey, Maria A, Quigley, Máire F, Gostick, Emma, Price, David A, Humphreys, Ian R

“…The beta-herpesvirus CMV induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral…”
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Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells by Smith, Corey, Elhassen, Diah, Gras, Stephanie, Wynn, Katherine K., Dasari, Vijayendra, Tellam, Judy, Tey, Siok-Keen, Rehan, Sweera, Liu, Yu Chih, Rossjohn, Jamie, Burrows, Scott R., Khanna, Rajiv

“…T-box transcription factors T-bet (Tbx21) and Eomesodermin (Eomes) are critical players in CD8+ cytotoxic T lymphocyte effector function and differentiation,…”
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Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection by Cole, David K., Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James P., Wynn, Katherine K., Gostick, Emma, Sewell, Andrew K., Gallimore, Awen M., Ladell, Kristin, Price, David A., Gougeon, Marie-Lise, Godkin, Andrew

“…Human CD4 + αβ T cells are activated via T-cell receptor recognition of peptide epitopes presented by major histocompatibility complex (MHC) class II (MHC-II)…”
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Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection by Wynn, Katherine K., Fulton, Zara, Cooper, Leanne, Silins, Sharon L., Gras, Stephanie, Archbold, Julia K., Tynan, Fleur E., Miles, John J., McCluskey, James, Burrows, Scott R., Rossjohn, Jamie, Khanna, Rajiv

“…CD8+ T-cell responses to persistent viral infections are characterized by the accumulation of an oligoclonal T-cell repertoire and a reduction in the naive…”
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Enhanced Induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic Cell-targeted Delivery of SOCS-1 siRNA by Subramanya, Sandesh, Armant, Myriam, Salkowitz, Janelle R, Nyakeriga, Alice M, Haridas, Viraga, Hasan, Maroof, Bansal, Anju, Goepfert, Paul A, Wynn, Katherine K, Ladell, Kristin, Price, David A, Manjunath, N, Kan-Mitchell, June, Shankar, Premlata

“…Dendritic cells (DCs) are potent antigen-presenting cells that play a critical role in the activation of T cells. RNA interference (RNAi)-mediated silencing of…”
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Narrowing of T-cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients by Wynn, Katherine K, Crough, Tania, Campbell, Scott, McNeil, Keith, Galbraith, Andrew, Moss, Denis J, Silins, Sharon L, Bell, Scott, Khanna, Rajiv

“…Primary infection or recrudescence of latent virus infection in transplant recipients can be manifested either as asymptomatic or symptomatic disease. Here we…”
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Interleukin-10 restricts memory T cell inflation during cytomegalovirus infection by Jones, Morgan, Ladell, Kristin, Wynn, Katherine K., Stacey, Maria A., Quigley, Máire F., Gostick, Emma, Price, David A., Humphreys, Ian R.

“…The beta-herpesvirus cytomegalovirus induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral…”
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Models of CMV infection by Wynn, Katherine K., Khanna, Rajiv

“…Herpes viruses characteristically persist within the cells of the immune system. A classic example is cytomegalovirus (CMV), which has coevolved with mammals…”
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