Search Results - "Wynn, Daniel T."

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling by Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Adams, Amber A., Silver-Isenstadt, Maya, Sawyer, Leah M., Benchabane, Hassina, Wang, Huilan, Bunnag, Nawat, Li, Bin, Wynn, Daniel T., Yang, Fan, Garcia-Contreras, Marta, Williams, Charles H., Dakshanamurthy, Sivanesan, Hong, Charles C., Ayad, Nagi G., Capobianco, Anthony J., Ahmed, Yashi, Lee, Ethan, Robbins, David J.

“…Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of IMiDs to Cereblon (CRBN), the…”
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Casein Kinase 1α as a Regulator of Wnt-Driven Cancer by Shen, Chen, Nayak, Anmada, Melendez, Ricardo A, Wynn, Daniel T, Jackson, Joshua, Lee, Ethan, Ahmed, Yashi, Robbins, David J

“…Wnt signaling regulates numerous cellular processes during embryonic development and adult tissue homeostasis. Underscoring this physiological importance,…”
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Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer by Yang, Fan, Wynn, Daniel T, Shen, Chen, Ayad, Nagi G, Robbins, David J

“…The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in…”
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Magnetically coupled percutaneous connector for chronic electrical peripheral nerve stimulation and recording in awake rats by Matarazzo, Jerico V., Williams-Wynn, Daniel T., Fallon, James B., Payne, Sophie C.

“…A fast-growing field of neuroscience and medicine is the treatment of disease via electrical stimulation of the peripheral nervous system. Peripheral nerve…”
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Exploring the role of casein kinase 1α splice variants across cancer cell lines by Meléndez, Ricardo A., Wynn, Daniel T., Merugu, Siva Bharath, Singh, Prerna, Kaplan, Kenton P., Robbins, David J.

“…Casein kinase 1α (CK1α) is a serine/threonine protein kinase that acts in various cellular processes affecting cell division and signal transduction. CK1α is…”
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A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth by Yang, Fan, Rodriguez-Blanco, Jezabel, Long, Jun, Swiderska-Syn, Marzena, Wynn, Daniel T, Li, Bin, Shen, Chen, Nayak, Anmada, Ban, Yuguang, Sun, Xiaodian, Suter, Robert K, McCrea, Heather J, Capobianco, Anthony J, Ayad, Nagi G, Robbins, David J

“…Dysregulation of Sonic hedgehog (SHH) signaling drives the growth of distinct cancer subtypes, including medulloblastoma (MB). Such cancers have been treated…”
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Triptolide and its prodrug Minnelide target high-risk MYC-amplified medulloblastoma in preclinical models by Rodriguez-Blanco, Jezabel, Salvador, April D, Suter, Robert K, Swiderska-Syn, Marzena, Palomo-Caturla, Isabel, Kliebe, Valentin, Shahani, Pritika, Peterson, Kendell, Turos-Cabal, Maria, Vieira, Megan E, Wynn, Daniel T, Howell, Ashley J, Yang, Fan, Ban, Yuguang, McCrea, Heather J, Zindy, Frederique, Danis, Etienne, Vibhakar, Rajeev, Jermakowicz, Anna, Martin, Vanesa, Coss, Christopher C, Harris, Brent T, de Cubas, Aguirre, Chen, X Steven, Barnoud, Thibaut, Roussel, Martine F, Ayad, Nagi G, Robbins, David J

“…Most children with medulloblastoma (MB) achieve remission, but some face very aggressive metastatic tumors. Their dismal outcome highlights the critical need…”
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Noncanonical activation of GLI signaling in SOX2 + cells drives medulloblastoma relapse by Swiderska-Syn, Marzena, Mir-Pedrol, Júlia, Oles, Alexander, Schleuger, Olga, Salvador, April D, Greiner, Sean M, Seward, Cara, Yang, Fan, Babcock, Benjamin R, Shen, Chen, Wynn, Daniel T, Sanchez-Mejias, Avencia, Gershon, Timothy R, Martin, Vanesa, McCrea, Heather J, Lindsey, Kathryn G, Krieg, Carsten, Rodriguez-Blanco, Jezabel

“…SRY (sex determining region Y)-box 2 (SOX2)-labeled cells play key roles in chemoresistance and tumor relapse; thus, it is critical to elucidate the mechanisms…”
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Protein arginine methyltransferase 5 regulates SHH-subgroup medulloblastoma progression by Wynn, Daniel T, Rodriguez-Blanco, Jezabel, Long, Jun, Yang, Fan, Shen, Chen, Fei, Dennis, Tang, Hsin-Yao, Hanson, Derek, Robbins, David J

“…Medulloblastoma (MB) is the most common pediatric brain tumor. Although standard-of-care treatment generally results in good prognosis, many patients exhibit…”
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Abstract 2814: Rectal implantation paves the path to evaluate the metabolic machinery responsible for CRC metastasis by Afify, Said M., Shen, Chen, Merugu, Siva B., Wynn, Daniel T., Nayak, Anmada, Lu, Wenhui, Calderin, Ricardo M., Pannkuk, Evan, Hong, Sung H., Ayad, Nagi G., Robbins, David J.

“…Abstract Introduction: Colorectal carcinoma patients die most often from distant metastases in liver and lung. It is crucial to develop metastatic models for…”
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