Search Results - "Wymant, Jennifer M"
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Simple and Versatile 3D Printed Microfluidics Using Fused Filament Fabrication
Published in PloS one (06-04-2016)“…The uptake of microfluidics by the wider scientific community has been limited by the fabrication barrier created by the skills and equipment required for the…”
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siRNA Inhibition of Endocytic Pathways to Characterize the Cellular Uptake Mechanisms of Folate-Functionalized Glycol Chitosan Nanogels
Published in Molecular pharmaceutics (01-06-2015)“…Glycol chitosan nanogels have been widely used in gene, drug, and contrast agent delivery in an effort to improve disease diagnosis and treatment. Herein, we…”
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Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells
Published in Biochemical pharmacology (01-02-2015)“…Disulfiram, a clinically used alcohol-deterrent has gained prominence as a potential anti-cancer agent due to its impact on copper-dependent processes. Few…”
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Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells
Published in European journal of medicinal chemistry (03-03-2016)“…Podophyllotoxin (PT) and its clinically used analogues are known to be powerful antitumour agents. These compounds contain a trans fused strained γ-lactone…”
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The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer
Published in Journal of Cancer (01-01-2016)“…Breast Cancer Associated gene 2 (BCA2) is an E3 ubiquitin ligase that is over-expressed in >50% of primary breast cancers, and has been shown to increase cell…”
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