Search Results - "Wymann, M P"

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor : the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses by ARCARO, A, WYMANN, M. P

“…Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant…”
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Mal connects TLR2 to PI3Kinase activation and phagocyte polarization by Santos-Sierra, S, Deshmukh, S D, Kalnitski, J, Küenzi, P, Wymann, M P, Golenbock, D T, Henneke, Philipp

“…The recognition of bacterial lipoproteins by toll‐like receptor (TLR) 2 is pivotal for inflammation initiation and control in many bacterial infections…”
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Key role of PI3Kγ in monocyte chemotactic protein‐1‐mediated amplification of PDGF‐induced aortic smooth muscle cell migration by Fougerat, A, Smirnova, NF, Gayral, S, Malet, N, Hirsch, E, Wymann, MP, Perret, B, Martinez, LO, Douillon, M, Laffargue, M

“…BACKGROUND AND PURPOSE Vascular smooth muscle cell (SMC) migration within the arterial wall is a crucial event in atherogenesis and restenosis. Monocyte…”
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Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP by Schmidt, C, Schneble, N, Müller, J.P, Bauer, R, Perino, A, Marone, R, Rybalkin, S.D, Wymann, M.P, Hirsch, E, Wetzker, R

“…Graphical abstract Highlights ► PI3Kγ controls microglial phagocytosis of bacteria and Zymosan particles. ► PI3Kγ affects microglial phagocytosis via…”
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Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation by Hirsch, Emilio, Katanaev, Vladimir L., Garlanda, Cecilia, Azzolino, Ornella, Pirola, Luciano, Silengo, Lorenzo, Sozzani, Silvano, Mantovani, Alberto, Altruda, Fiorella, Wymann, Matthias P.

“…Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the four receptor-activated isoforms are unclear. Mice lacking…”
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Luminal decoration of blood vessels by activated perivasal mast cells in allergic rhinitis by Schaefer, T., Zajonz, A., Lorentz, P., Bohnacker, T., Wymann, M. P., Schweighoffer, T.

“…Background In allergic diseases, like in rhinitis, antigen challenge induces rapid degranulation of tissue resident mast cells and subsequent recruitment of…”
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Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy by Wymann, M P, Björklöf, K, Calvez, R, Finan, P, Thomast, M, Trifilieff, A, Barbier, M, Altruda, F, Hirsch, E, Laffargue, M

“…Chronic inflammation and allergy involve the activation of tissue-resident cells and, later on, the invasion of effector cells. We have previously shown that…”
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Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction by Wymann, Matthias P., Bulgarelli-Leva, Ginette, Zvelebil, Marketa J., Pirola, Luciano, Vanhaesebroeck, Bart, Waterfield, Michael D., Panayotou, George

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Protein adsorption on topographically nanostructured titanium by Galli, C., Collaud Coen, M., Hauert, R., Katanaev, V.L., Wymann, M.P., Gröning, P., Schlapbach, L.

“…We study the protein adsorption on surfaces in order to investigate their predominant role in biocompatibility. Nanostructures are created by local anodic…”
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Tumour biology (Communication arising) Weakening link to colorectal cancer? by Wymann, M. P, Barbier, M, Attoub, S, Calvez, R, Laffargue, M, Jarry, A, Mareel, M, Altruda, F, Gespach, C, Wu, D, Lu, B, Hirsch, E

“…The catalytic γ-subunit of the enzyme phosphatidylinositol-3-OH kinase (PI(3)Kγ) relays signals from G- protein-coupled receptors at the cell membrane and…”
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Wortmannin Binds Specifically to 1-Phosphatidylinositol 3-Kinase While Inhibiting Guanine Nucleotide-Binding Protein-Coupled Receptor Signaling in Neutrophil Leukocytes by Thelen, Marcus, Wymann, Matthias P., Langen, Hanno

“…Wortmannin (WT) and its derivative 17-hydroxywortmannin (HWT) inhibit at nanomolar concentrations superoxide formation and exocytosis in neutrophils stimulated…”
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Structure and function of phosphoinositide 3-kinases by Wymann, Matthias P, Pirola, Luciano

“…Phosphoinositide kinases (PI3Ks) play an important role in mitogenic signaling and cell survival, cytoskeletal remodeling, metabolic control and vesicular…”
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Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function by Laffargue, Muriel, Calvez, Ronan, Finan, Peter, Trifilieff, Alexandre, Barbier, Maryse, Altruda, Fiorella, Hirsch, Emilio, Wymann, Matthias P

“…Mast cells are key regulators in allergy and inflammation, and release histamine upon clustering of their IgE receptors. Here we demonstrate that murine mast…”
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GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptors by Vetiska, S M, Ahmadian, G, Ju, W, Liu, L, Wymann, M P, Wang, Y T

“…Type A gamma-aminobutyric acid (GABAA) receptors mediate most of the fast inhibitory synaptic transmission within the vertebrate brain. The regulation of this…”
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Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils by KERNEN, P, WYMANN, M. P, VON TSCHARNER, V, DERANLEAU, D. A, PO-CHUN TAI, SPRY, C. J, DAHINDEN, C. A, BAGGIOLINI, M

“…Essentially pure preparations of normal density eosinophils obtained from patients with hypereosinophilic syndrome (HES) were stimulated with complement factor…”
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Increased breakdown of phosphatidylinositol 4,5-bisphosphate is not an initiating factor for actin assembly in human neutrophils by Bengtsson, T, Rundquist, I, Stendahl, O, Wymann, M P, Andersson, T

“…The present study examined the possible role of increased phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) breakdown in the regulation of actin assembly…”
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Corresponding oscillations in neutrophil shape and filamentous actin content by WYMANN, M. P, KERNEN, P, BENGTSSON, T, ANDERSSON, T, BAGGIOLINI, M, DERANLEAU, D. A

“…Human neutrophils pretreated with 17-hydroxywortmannin responded to the chemotactic agonist formyl-Met-Leu-Phe with a transient doubling in filamentous actin…”
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Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB by Stocker, Hugo, Andjelkovic, Mirjana, Oldham, Sean, Laffargue, Muriel, Wymann, Matthias P., Hemmings, Brian A., Hafen, Ernst

“…The phosphoinositide phosphatase PTEN is mutated in many human cancers. Although the role of PTEN has been studied extensively, the relative contributions of…”
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The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process by Wymann, M P, von Tscharner, V, Deranleau, D A, Baggiolini, M

“…A real-time study of the initiation of the respiratory burst in human neutrophils was made. The cells were stimulated with fMet-Leu-Phe (fMLP) C5a,…”
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Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, Rho‐, and Rac‐dependent signaling pathways by Attoub, Samir, Noe, Veerle, Pirola, Luciano, Bruyneel, Erik, Chastre, Eric, Mareel, Marc, Wymann, Matthias P., Gespach, Christian

“…Leptin plays a key role regulating food intake, body weight and fat mass. These critical parameters are associated with an increased risk for digestive and…”
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