Search Results - "Wyllie, David J.A."

The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults by Martel, Marc-André, Ryan, Tomás J., Bell, Karen F.S., Fowler, Jill H., McMahon, Aoife, Al-Mubarak, Bashayer, Komiyama, Noboru H., Horsburgh, Karen, Kind, Peter C., Grant, Seth G.N., Wyllie, David J.A., Hardingham, Giles E.

“…It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca2+ influx is…”
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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses by Hardingham, Giles E, Papadia, Sofia, Soriano, Francesc X, Léveillé, Frédéric, Martel, Marc-Andre, Dakin, Kelly A, Hansen, Henrik H, Kaindl, Angela, Sifringer, Marco, Fowler, Jill, Stefovska, Vanya, Mckenzie, Grahame, Craigon, Marie, Corriveau, Roderick, Ghazal, Peter, Horsburgh, Karen, Yankner, Bruce A, Wyllie, David J A, Ikonomidou, Chrysanthy

“…Intrinsic antioxidant defenses are important for neuronal longevity. We found that in rat neurons, synaptic activity, acting via NMDA receptor (NMDAR)…”
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Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome by Thomson, Sophie R., Seo, Sang S., Barnes, Stephanie A., Louros, Susana R., Muscas, Melania, Dando, Owen, Kirby, Caoimhe, Wyllie, David J.A., Hardingham, Giles E., Kind, Peter C., Osterweil, Emily K.

“…Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu1/5) is a core pathophysiology of fragile X syndrome (FX); however, the…”
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Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons by Sharma, Shreya Das, Reddy, Bharath Kumar, Pal, Rakhi, Ritakari, Tuula E., Cooper, James D., Selvaraj, Bhuvaneish T., Kind, Peter C., Chandran, Siddharthan, Wyllie, David J.A., Chattarji, Sumantra

“…Pre-clinical studies of fragile X syndrome (FXS) have focused on neurons, with the role of glia remaining largely underexplored. We examined the astrocytic…”
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Maturation and electrophysiological properties of human pluripotent stem cell‐derived oligodendrocytes by Livesey, Matthew R., Magnani, Dario, Cleary, Elaine M., Vasistha, Navneet A., James, Owain T., Selvaraj, Bhuvaneish T., Burr, Karen, Story, David, Shaw, Christopher E., Kind, Peter C., Hardingham, Giles E., Wyllie, David J.A., Chandran, Siddharthan

“…Rodent‐based studies have shown that the membrane properties of oligodendrocytes play prominent roles in their physiology and shift markedly during their…”
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Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome by Booker, Sam A., Simões de Oliveira, Laura, Anstey, Natasha J., Kozic, Zrinko, Dando, Owen R., Jackson, Adam D., Baxter, Paul S., Isom, Lori L., Sherman, Diane L., Hardingham, Giles E., Brophy, Peter J., Wyllie, David J.A., Kind, Peter C.

“…Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing…”
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The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences by McKay, Sean, Ryan, Tomás J., McQueen, Jamie, Indersmitten, Tim, Marwick, Katie F.M., Hasel, Philip, Kopanitsa, Maksym V., Baxter, Paul S., Martel, Marc-André, Kind, Peter C., Wyllie, David J.A., O’Dell, Thomas J., Grant, Seth G.N., Hardingham, Giles E., Komiyama, Noboru H.

“…The GluN2 subtype (2A versus 2B) determines biophysical properties and signaling of forebrain NMDA receptors (NMDARs). During development, GluN2A becomes…”
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Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons by Livesey, Matthew R, Bilican, Bilada, Qiu, Jing, Rzechorzek, Nina M, Haghi, Ghazal, Burr, Karen, Hardingham, Giles E, Chandran, Siddharthan, Wyllie, David J A

“…Rodent-based studies have shown that neurons undergo major developmental changes to ion channel expression and ionic gradients that determine their…”
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Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure by McKay, Sean, Bengtson, C. Peter, Bading, Hilmar, Wyllie, David J.A., Hardingham, Giles E.

“…MK-801 is a use-dependent NMDA receptor open channel blocker with a very slow off-rate. These properties can be exploited to ‘pre-block’ a population of…”
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Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons by Booker, Sam A., Loreth, Desiree, Gee, Annabelle L., Watanabe, Masahiko, Kind, Peter C., Wyllie, David J.A., Kulik, Ákos, Vida, Imre

“…Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAA and metabotropic GABAB receptors (GABABRs). Despite GABABRs representing a…”
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Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits by O'Leary, Timothy, Wyllie, David J A

“…Subtypes of NMDARs (N-methyl-D-aspartate receptors) display differences in their pharmacological and biophysical properties. The differences are, to a large…”
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Functional assessment of the NMDA receptor variant GluN2AR586K by Marwick, Katie F.M., Parker, Peter, Skehel, Paul, Hardingham, Giles, Wyllie, David J.A.

“…Background: The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that has important roles in synaptogenesis, synaptic transmission,…”
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Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition by Rzechorzek, Nina M., Connick, Peter, Livesey, Matthew R., Borooah, Shyamanga, Patani, Rickie, Burr, Karen, Story, David, Wyllie, David J.A., Hardingham, Giles E., Chandran, Siddharthan

“…Hypothermia is potently neuroprotective, but the molecular basis of this effect remains obscure. Changes in neuronal tau protein are of interest, since tau…”
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Functional assessment of the NMDA receptor variant GluN2AR586K by Marwick, Katie F.M., Parker, Peter, Skehel, Paul, Hardingham, Giles, Wyllie, David J.A.

“…Background: The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that has important roles in synaptogenesis, synaptic transmission,…”
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Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies by Otton, Hannah J, Janssen, Ariane, Wyllie, David J A

“…NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and…”
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Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression by Martel, Marc-Andre, Soriano, Frances X., Baxter, Paul, Rickman, Colin, Duncan, Rory, Wyllie, David J.A., Hardingham, Giles E.

“…NMDA receptors (NMDARs) mediate ischemic brain damage, in part through interactions of the PDZ ligand of NR2 subunits with the PDZ domain proteins PSD-95 and…”
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Ionotropic glutamate receptors: structure, function and dysfunction by Wyllie, David J. A., Bowie, Derek

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NMDA receptor function in inhibitory neurons by Booker, Sam A., Wyllie, David J.A.

“…N-methyl-d-aspartate receptors (NMDARs) are present in the majority of brain circuits and play a key role in synaptic information transfer and synaptic…”
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Thesis write‐up and manuscript preparation: related but distinct tasks by Wyllie, David J. A.

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GRIN2A-related disorders: genotype and functional consequence predict phenotype by Strehlow, Vincent, Heyne, Henrike O, Vlaskamp, Danique R M, Marwick, Katie F M, Rudolf, Gabrielle, de Bellescize, Julitta, Biskup, Saskia, Brilstra, Eva H, Brouwer, Oebele F, Callenbach, Petra M C, Hentschel, Julia, Hirsch, Edouard, Kind, Peter C, Mignot, Cyril, Platzer, Konrad, Rump, Patrick, Skehel, Paul A, Wyllie, David J A, Hardingham, Giles E, van Ravenswaaij-Arts, Conny M A, Lesca, Gaetan, Lemke, Johannes R

“…Strehlow et al. describe the largest cohort to date of individuals with GRIN2A-related disorders. The results reveal two phenotypic subgroups associated with…”
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