Search Results - "Wylie, C."

Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline by Hembree, Wylie C, Cohen-Kettenis, Peggy T, Gooren, Louis, Hannema, Sabine E, Meyer, Walter J, Murad, M Hassan, Rosenthal, Stephen M, Safer, Joshua D, Tangpricha, Vin, T’Sjoen, Guy G

“…Abstract Objective To update the “Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline,” published by the Endocrine…”
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Should evolutionary geneticists worry about higher-order epistasis? by Weinreich, Daniel M, Lan, Yinghong, Wylie, C Scott, Heckendorn, Robert B

“…Natural selection drives evolving populations up the fitness landscape, the projection from nucleotide sequence space to organismal reproductive success. While…”
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biophysical protein folding model accounts for most mutational fitness effects in viruses by Wylie, C. Scott, Shakhnovich, Eugene I

“…Fitness effects of mutations fall on a continuum ranging from lethal to deleterious to beneficial. The distribution of fitness effects (DFE) among random…”
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Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical Practice Guideline by Hembree, Wylie C., Cohen-Kettenis, Peggy, Delemarre-van de Waal, Henriette A., Gooren, Louis J., Meyer, Walter J., Spack, Norman P., Tangpricha, Vin, Montori, Victor M.

“…Objective: The aim was to formulate practice guidelines for endocrine treatment oftranssexual persons. Evidence: This evidence-based guideline was developed…”
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Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx by Singh, Anurag, Ramnath, Raina D, Foster, Rebecca R, Wylie, Emma C, Fridén, Vincent, Dasgupta, Ishita, Haraldsson, Borje, Welsh, Gavin I, Mathieson, Peter W, Satchell, Simon C

“…Reactive oxygen species (ROS) play a key role in the pathogenesis of proteinuria in glomerular diseases like diabetic nephropathy. Glomerular endothelial cell…”
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Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance by Ogbunugafor, C Brandon, Wylie, C Scott, Diakite, Ibrahim, Weinreich, Daniel M, Hartl, Daniel L

“…The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that…”
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Sign of selection on mutation rate modifiers depends on population size by Raynes, Yevgeniy, Wylie, C. Scott, Sniegowski, Paul D., Weinreich, Daniel M.

“…The influence of population size (N) on natural selection acting on alleles that affect fitness has been understood for almost a century. As N declines,…”
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A systematic literature search to identify performance measure outcomes used in clinical studies of racehorses by Wylie, C. E., Newton, J. R.

“…Summary Background Racing performance is often used as a measurable outcome variable in research studies investigating clinical diagnoses or interventions…”
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Intergenerational effects of racism on amygdala and hippocampus resting state functional connectivity by Kral, T. R. A., Williams, C. Y., Wylie, A. C., McLaughlin, K., Stephens, R. L., Mills-Koonce, W. R., Birn, R. M., Propper, C. B., Short, S. J.

“…Racism is an insidious problem with far-reaching effects on the lives of Black, Indigenous, and People of Color (BIPOC). The pervasive negative impact of…”
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Sodium content as a predictor of the advanced evolution of globular cluster stars by Campbell, Simon W., D’Orazi, Valentina, Yong, David, Constantino, Thomas N., Lattanzio, John C., Stancliffe, Richard J., Angelou, George C., Wylie-de Boer, Elizabeth C., Grundahl, Frank

“…Investigations show that all the second-generation stars in the globular cluster NGC 6752 fail to reach the asymptotic giant branch (AGB) phase; every AGB star…”
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Author Correction: Intergenerational effects of racism on amygdala and hippocampus resting state functional connectivity by Kral, T. R. A., Williams, C. Y., Wylie, A. C., McLaughlin, K., Stephens, R. L., Mills‑Koonce, W. R., Birn, R. M., Propper, C. B., Short, S. J.

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Prevalence of and risk factors for equine obesity in Great Britain based on owner‐reported body condition scores by Robin, C. A., Ireland, J. L., Wylie, C. E., Collins, S. N., Verheyen, K. L. P., Newton, J. R.

“…REASONS FOR PERFORMING THE STUDY: Few data are available on the prevalence of obesity in the general equine population of Great Britain (GB), and its…”
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Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus Embryos by Tao, Qinghua, Yokota, Chika, Puck, Helbert, Kofron, Matt, Birsoy, Bilge, Yan, Dong, Asashima, Makoto, Wylie, Christopher C., Lin, Xinhua, Heasman, Janet

“…Wnt signaling pathways play essential roles in patterning and proliferation of embryonic and adult tissues. In many organisms, this signaling pathway directs…”
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Identification of modifiable factors associated with owner-reported equine laminitis in Britain using a web-based cohort study approach by Pollard, D, Wylie, C E, Verheyen, K L P, Newton, J R

“…Equine laminitis is a complex disease that manifests as pain and lameness in the feet, often with debilitating consequences. There is a paucity of data that…”
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Functional Access to Neuron Subclasses in Rodent and Primate Forebrain by Mehta, Preeti, Kreeger, Lauren, Wylie, Dennis C., Pattadkal, Jagruti J., Lusignan, Tara, Davis, Matthew J., Turi, Gergely F., Li, Wen-Ke, Whitmire, Matthew P., Chen, Yuzhi, Kajs, Bridget L., Seidemann, Eyal, Priebe, Nicholas J., Losonczy, Attila, Zemelman, Boris V.

“…Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific…”
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Prospective, retrospective or clinical audit: A label that sticks by Wylie, C. E.

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Mutation induced extinction in finite populations: lethal mutagenesis and lethal isolation by Wylie, C Scott, Shakhnovich, Eugene I

“…Reproduction is inherently risky, in part because genomic replication can introduce new mutations that are usually deleterious toward fitness. This risk is…”
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Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse by Winkler, Tamara, Mahoney, Eric J, Sinner, Debora, Wylie, Christopher C, Dahia, Chitra Lekha

“…Intervertebral discs (IVDs) are strong fibrocartilaginous joints that connect adjacent vertebrae of the spine. As discs age they become prone to failure, with…”
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Incidence and clinical signs of owner‐reported equine laminitis in a cohort of horses and ponies in Great Britain by Pollard, D., Wylie, C. E., Newton, J. R., Verheyen, K. L. P.

“…Summary Background Previous robust epidemiological studies of equine laminitis have utilised only veterinary‐diagnosed episodes of disease, potentially…”
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Nonsurgical and surgical management of metacarpo/metatarsophalangeal joint dorsal chip fracture in the Thoroughbred racehorse by Ramzan, P. H. L., Wylie, C. E.

“…Summary Background Arthroscopy is considered the treatment of choice for dorsal osteochondral chip fractures of the metacarpo/metatarsophalangeal (MCP/MTP)…”
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