Search Results - "Wyles, Matthew"

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus by Korber, Bette, Fischer, Will M., Gnanakaran, Sandrasegaram, Yoon, Hyejin, Theiler, James, Abfalterer, Werner, Hengartner, Nick, Giorgi, Elena E., Bhattacharya, Tanmoy, Foley, Brian, Hastie, Kathryn M., Parker, Matthew D., Partridge, David G., Evans, Cariad M., Freeman, Timothy M., de Silva, Thushan I., Angyal, Adrienne, Brown, Rebecca L., Carrilero, Laura, Green, Luke R., Groves, Danielle C., Johnson, Katie J., Keeley, Alexander J., Lindsey, Benjamin B., Parsons, Paul J., Raza, Mohammad, Rowland-Jones, Sarah, Smith, Nikki, Tucker, Rachel M., Wang, Dennis, Wyles, Matthew D., McDanal, Charlene, Perez, Lautaro G., Tang, Haili, Moon-Walker, Alex, Whelan, Sean P., LaBranche, Celia C., Saphire, Erica O., Montefiori, David C.

“…A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant…”
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Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity by Waller, Rachel, Wyles, Matthew, Heath, Paul R, Kazoka, Mbombe, Wollff, Helen, Shaw, Pamela J, Kirby, Janine

“…Amyotrophic lateral sclerosis (ALS) is a clinical subtype of motor neurone disease (MND), a fatal neurodegenerative disease involving the loss of both the…”
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Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy by Valori, Chiara F, Ning, Ke, Wyles, Matthew, Mead, Richard J, Grierson, Andrew J, Shaw, Pamela J, Azzouz, Mimoun

“…Spinal muscular atrophy is one of the most common genetic causes of death in childhood, and there is currently no effective treatment. The disease is caused by…”
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C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis by Cooper-Knock, Johnathan, Bury, Joanna J, Heath, Paul R, Wyles, Matthew, Higginbottom, Adrian, Gelsthorpe, Catherine, Highley, J Robin, Hautbergue, Guillaume, Rattray, Magnus, Kirby, Janine, Shaw, Pamela J

“…An intronic GGGGCC-repeat expansion of C9ORF72 is the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The…”
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Diagnosis of SARS-CoV-2 Infection with LamPORE, a High-Throughput Platform Combining Loop-Mediated Isothermal Amplification and Nanopore Sequencing by Peto, Leon, Rodger, Gillian, Carter, Daniel P, Osman, Karen L, Yavuz, Mehmet, Johnson, Katie, Raza, Mohammad, Parker, Matthew D, Wyles, Matthew D, Andersson, Monique, Justice, Anita, Vaughan, Alison, Hoosdally, Sarah, Stoesser, Nicole, Matthews, Philippa C, Eyre, David W, Peto, Timothy E A, Carroll, Miles W, de Silva, Thushan I, Crook, Derrick W, Evans, Cariad M, Pullan, Steven T

“…LamPORE is a novel diagnostic platform for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA combining loop-mediated isothermal…”
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Transcriptomic analysis of the human placenta reveals trophoblast dysfunction and augmented Wnt signalling associated with spontaneous preterm birth by Akram, Khondoker M., Kulkarni, Neha S., Brook, Abbey, Wyles, Matthew D., Anumba, Dilly O. C.

“…Preterm birth (PTB) is the leading cause of death in under-five children. Worldwide, annually, over 15 million babies are born preterm and 1 million of them…”
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A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis by Cooper-Knock, Johnathan, Green, Claire, Altschuler, Gabriel, Wei, Wenbin, Bury, Joanna J, Heath, Paul R, Wyles, Matthew, Gelsthorpe, Catherine, Highley, J Robin, Lorente-Pons, Alejandro, Beck, Tim, Doyle, Kathryn, Otero, Karel, Traynor, Bryan, Kirby, Janine, Shaw, Pamela J, Hide, Winston

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. Continued focus on…”
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Comparison of blood RNA extraction methods used for gene expression profiling in amyotrophic lateral sclerosis by Bayatti, Nadhim, Cooper-Knock, Johnathan, Bury, Joanna J, Wyles, Matthew, Heath, Paul R, Kirby, Janine, Shaw, Pamela J

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes death within a mean of 2-3 years from symptom onset. There is no diagnostic test…”
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Targeted genetic screen in Amyotrophic lateral sclerosis reveals novel genetic variants with synergistic effect on clinical phenotype by Cooper-Knock, Johnathan, Robins, Henry, Niedermoser, Isabell, Wyles, Matthew, Heath, Paul R., Higginbottom, Adrian, Walsh, Theresa, Kazoka, Mbombe, Ince, Paul G., Hautbergue, Guillaume M., McDermott, Christopher J., Kirby, Janine, Shaw, Pamela J., Project MinE ALS Sequencing Consortium, de Carvalho, Mamede, Pinto, Susana

“…Copyright © 2017 Cooper-Knock, Robins, Niedermoser, Wyles, Heath, Higginbottom, Walsh, Kazoka, Project MinE ALS Sequencing Consortium, Ince, Hautbergue,…”
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Development and applications of non-HIV-based lentiviral vectors in neurological disorders by Valori, Chiara F, Ning, Ke, Wyles, Matthew, Azzouz, Mimoun

“…Vectors based on non-HIV lentiviruses are opening up new approaches for the treatment of human disorders. These vectors efficiently deliver genes into many…”
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SARS-CoV-2 evolution during treatment of chronic infection by Kemp, Steven A., Collier, Dami A., Datir, Rawlings P., Ferreira, Isabella A. T. M., Gayed, Salma, Jahun, Aminu, Hosmillo, Myra, Rees-Spear, Chloe, Mlcochova, Petra, Lumb, Ines Ushiro, Roberts, David J., Chandra, Anita, Temperton, Nigel, Sharrocks, Katherine, Blane, Elizabeth, Modis, Yorgo, Leigh, Kendra E., Briggs, John A. G., van Gils, Marit J., Smith, Kenneth G. C., Bradley, John R., Smith, Chris, Doffinger, Rainer, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Pollock, David D., Goldstein, Richard A., Smielewska, Anna, Skittrall, Jordan P., Gouliouris, Theodore, Goodfellow, Ian G., Gkrania-Klotsas, Effrossyni, Illingworth, Christopher J. R., McCoy, Laura E., Gupta, Ravindra K.

“…The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2…”
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Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease by Carling, Phillippa J, Mortiboys, Heather, Green, Claire, Mihaylov, Simeon, Sandor, Cynthia, Schwartzentruber, Aurelie, Taylor, Rosie, Wei, Wenbin, Hastings, Chris, Wong, Siew, Lo, Christine, Evetts, Samuel, Clemmens, Hannah, Wyles, Matthew, Willcox, Sam, Payne, Thomas, Hughes, Rachel, Ferraiuolo, Laura, Webber, Caleb, Hide, Winston, Wade-Martins, Richard, Talbot, Kevin, Hu, Michele T., Bandmann, Oliver

“…•We undertook fibroblast-based deep phenotyping in sporadic Parkinson’s disease (sPD).•We identified distinct subgroups with mitochondrial or lysosomal…”
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Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data by Parker, Matthew D, Lindsey, Benjamin B, Leary, Shay, Gaudieri, Silvana, Chopra, Abha, Wyles, Matthew, Angyal, Adrienn, Green, Luke R, Parsons, Paul, Tucker, Rachel M, Brown, Rebecca, Groves, Danielle, Johnson, Katie, Carrilero, Laura, Heffer, Joe, Partridge, David G, Evans, Cariad, Raza, Mohammad, Keeley, Alexander J, Smith, Nikki, Filipe, Ana Da Silva, Shepherd, James G, Davis, Chris, Bennett, Sahan, Sreenu, Vattipally B, Kohl, Alain, Aranday-Cortes, Elihu, Tong, Lily, Nichols, Jenna, Thomson, Emma C, Wang, Dennis, Mallal, Simon, de Silva, Thushan I

“…We have developed periscope, a tool for the detection and quantification of subgenomic RNA (sgRNA) in SARS-CoV-2 genomic sequence data. The translation of the…”
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PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons by Ning, Ke, Drepper, Carsten, Valori, Chiara F., Ahsan, Mansoor, Wyles, Matthew, Higginbottom, Adrian, Herrmann, Thomas, Shaw, Pamela, Azzouz, Mimoun, Sendtner, Michael

“…Phosphatase and tensin homolog (PTEN), a negative regulator of the mammalian target of rapamycin (mTOR) pathway, is widely involved in the regulation of…”
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Viral Delivery of Antioxidant Genes as a Therapeutic Strategy in Experimental Models of Amyotrophic Lateral Sclerosis by Nanou, Aikaterini, Higginbottom, Adrian, Valori, Chiara F, Wyles, Matthew, Ning, Ke, Shaw, Pamela, Azzouz, Mimoun

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology,…”
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Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis by Cooper-Knock, Johnathan, Moll, Tobias, Ramesh, Tennore, Castelli, Lydia, Beer, Alexander, Robins, Henry, Fox, Ian, Niedermoser, Isabell, Van Damme, Philip, Moisse, Matthieu, Robberecht, Wim, Hardiman, Orla, Panades, Monica P., Assialioui, Abdelilah, Mora, Jesus S., Basak, A. Nazli, Morrison, Karen E., Shaw, Christopher E., Al-Chalabi, Ammar, Landers, John E., Wyles, Matthew, Heath, Paul R., Higginbottom, Adrian, Walsh, Theresa, Kazoka, Mbombe, McDermott, Christopher J., Hautbergue, Guillaume M., Kirby, Janine, Shaw, Pamela J.

“…Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder without effective neuroprotective therapy. Known genetic variants impair pathways,…”
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PTEN Depletion Decreases Disease Severity and Modestly Prolongs Survival in a Mouse Model of Spinal Muscular Atrophy by Little, Daniel, Valori, Chiara F, Mutsaers, Chantal A, Bennett, Ellen J, Wyles, Matthew, Sharrack, Basil, Shaw, Pamela J, Gillingwater, Thomas H, Azzouz, Mimoun, Ning, Ke

“…Spinal muscular atrophy (SMA) is the second most common genetic cause of death in childhood. However, no effective treatment is available to halt disease…”
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Transcriptomic Profiling Reveals Discrete Poststroke Dementia Neuronal and Gliovascular Signatures by Waller, Rachel, Hase, Yoshiki, Simpson, Julie E., Heath, Paul R., Wyles, Matthew, Kalaria, Rajesh N., Wharton, Stephen B.

“…Poststroke dementia (PSD) is associated with pathology in frontal brain regions, in particular dorsolateral prefrontal cortex (DLPFC) neurons and white matter,…”
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Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves by Lindsey, Benjamin B., Villabona-Arenas, Ch. Julián, Campbell, Finlay, Keeley, Alexander J., Parker, Matthew D., Shah, Dhruv R., Parsons, Helena, Zhang, Peijun, Kakkar, Nishchay, Gallis, Marta, Foulkes, Benjamin H., Wolverson, Paige, Louka, Stavroula F., Christou, Stella, State, Amy, Johnson, Katie, Raza, Mohammad, Hsu, Sharon, Jombart, Thibaut, Cori, Anne, Evans, Cariad M., Partridge, David G., Atkins, Katherine E., Hué, Stéphane, de Silva, Thushan I.

“…Hospital outbreaks of COVID19 result in considerable mortality and disruption to healthcare services and yet little is known about transmission within this…”
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Establishing mRNA and microRNA interactions driving disease heterogeneity in amyotrophic lateral sclerosis patient survival by Waller, Rachel, Bury, Joanna J, Appleby-Mallinder, Charlie, Wyles, Matthew, Loxley, George, Babel, Aditi, Shekari, Saleh, Kazoka, Mbombe, Wollff, Helen, Al-Chalabi, Ammar, Heath, Paul R, Shaw, Pamela J, Kirby, Janine

“…Abstract Amyotrophic lateral sclerosis is a fatal neurodegenerative disease, associated with the degeneration of both upper and lower motor neurons of the…”
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