Search Results - "Wykoff, Jason A."

SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia by Meganck, Rita M., Edwards, Caitlin E., Mallory, Michael L., Lee, Rhianna E., Dang, Hong, Bailey, Alexis B., Wykoff, Jason A., Gallant, Samuel C., Zhu, Deanna R., Yount, Boyd L., Kato, Takafumi, Shaffer, Kendall M., Nakano, Satoko, Cawley, Anne Marie, Sontake, Vishwaraj, Wang, Jeremy R., Hagan, Robert S., Miller, Melissa B., Tata, Purushothama Rao, Randell, Scott H., Tse, Longping V., Ehre, Camille, Okuda, Kenichi, Boucher, Richard C., Baric, Ralph S.

“…The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the emergence of novel variants of concern (VOCs) that replace ancestral…”
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SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13 by Morrison, Cameron B, Edwards, Caitlin E, Shaffer, Kendall M, Araba, Kenza C, Wykoff, Jason A, Williams, Danielle R, Asakura, Takanori, Dang, Hong, Morton, Lisa C, Gilmore, Rodney C, O'Neal, Wanda K, Boucher, Richard C, Baric, Ralph S, Ehre, Camille

“…Muco-obstructive lung diseases are typically associated with high risks of COVID-19 severity; however, allergic asthma showed reduced susceptibility. To…”
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Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration by Morrison, Cameron B, Shaffer, Kendall M, Araba, Kenza C, Markovetz, Matthew R, Wykoff, Jason A, Quinney, Nancy L, Hao, Shuyu, Delion, Martial F, Flen, Alexis L, Morton, Lisa C, Liao, Jimmy, Hill, David B, Drumm, Mitchell L, O'Neal, Wanda K, Kesimer, Mehmet, Gentzsch, Martina, Ehre, Camille

“…Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent mucus in the lungs. While several hypotheses invoke a direct relationship with…”
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Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection by Tse, Longping V, Meganck, Rita M, Araba, Kenza C, Yount, Boyd L, Shaffer, Kendall M, Hou, Yixuan J, Munt, Jennifer E, Adams, Lily E, Wykoff, Jason A, Morowitz, Jeremy M, Dong, Stephanie, Magness, Scott T, Marzluff, William F, Gonzalez, Liara M, Ehre, Camille, Baric, Ralph S

“…Zoonotic transmission of coronaviruses poses an ongoing threat to human populations. Endemic outbreaks of swine acute diarrhea syndrome coronavirus (SADS-CoV)…”
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Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration by Mikami, Yu, Grubb, Barbara R, Rogers, Troy D, Dang, Hong, Asakura, Takanori, Kota, Pradeep, Gilmore, Rodney C, Okuda, Kenichi, Morton, Lisa C, Sun, Ling, Chen, Gang, Wykoff, Jason A, Ehre, Camille, Vilar, Juan, van Heusden, Catharina, Livraghi-Butrico, Alessandra, Gentzsch, Martina, Button, Brian, Stutts, M Jackson, Randell, Scott H, O'Neal, Wanda K, Boucher, Richard C

“…Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than the vasculature. Many pulmonary diseases are associated with…”
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Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer by Wykoff, Jason A, Shaffer, Kendall M, Araba, Kenza C, Markovetz, Matthew R, Patarin, Jérémy, Robert de Saint Vincent, Matthieu, Donaldson, Scott H, Ehre, Camille

“…In muco-obstructive lung diseases (e.g., asthma, chronic obstructive pulmonary disease, cystic fibrosis) and other respiratory conditions (e.g.,…”
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