Search Results - "Wykes, Michelle"

Immune checkpoint blockade in infectious diseases by Wykes, Michelle N., Lewin, Sharon R.

“…Key Points Immunosuppressive pathways or immune checkpoints refer to inhibitory receptors expressed on immune cells that are crucial for maintaining…”
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The mammalian PYHIN gene family: phylogeny, evolution and expression by Cridland, Jasmyn A, Curley, Eva Z, Wykes, Michelle N, Schroder, Kate, Sweet, Matthew J, Roberts, Tara L, Ragan, Mark A, Kassahn, Karin S, Stacey, Katryn J

“…Proteins of the mammalian PYHIN (IFI200/HIN-200) family are involved in defence against infection through recognition of foreign DNA. The family member absent…”
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Progression of Disease Within 24 Months in Follicular Lymphoma Is Associated With Reduced Intratumoral Immune Infiltration by Tobin, Joshua W D, Keane, Colm, Gunawardana, Jay, Mollee, Peter, Birch, Simone, Hoang, Thanh, Lee, Justina, Li, Li, Huang, Li, Murigneux, Valentine, Fink, J Lynn, Matigian, Nicholas, Vari, Frank, Francis, Santiyagu, Kridel, Robert, Weigert, Oliver, Haebe, Sarah, Jurinovic, Vindi, Klapper, Wolfram, Steidl, Christian, Sehn, Laurie H, Law, Soi-Cheng, Wykes, Michelle N, Gandhi, Maher K

“…Understanding the immunobiology of the 15% to 30% of patients with follicular lymphoma (FL) who experience progression of disease within 24 months (POD24)…”
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PD-1 Dependent Exhaustion of CD8+ T Cells Drives Chronic Malaria by Horne-Debets, Joshua M., Faleiro, Rebecca, Karunarathne, Deshapriya S., Liu, Xue Q., Lineburg, Katie E., Poh, Chek Meng, Grotenbreg, Gijsbert M., Hill, Geoffrey R., MacDonald, Kelli P.A., Good, Michael F., Renia, Laurent, Ahmed, Rafi, Sharpe, Arlene H., Wykes, Michelle N.

“…Malaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect hepatocytes and erythrocytes. Blood-stage infections cause…”
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Soluble immune checkpoints as correlates for HIV persistence and T cell function in people with HIV on antiretroviral therapy by Chiu, Chris Y, Schou, Maya D, McMahon, James H, Deeks, Steven G, Fromentin, Rémi, Chomont, Nicolas, Wykes, Michelle N, Rasmussen, Thomas A, Lewin, Sharon R

“…In people with HIV (PWH) both off and on antiretroviral therapy (ART), the expression of immune checkpoint (IC) proteins is elevated on the surface of total…”
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Why haven't we made an efficacious vaccine for malaria? by Wykes, Michelle N

“…The malaria parasite has an extraordinary ability to evade the immune system, which may explain the failure of malaria vaccines to date. It is high time to…”
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Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4+ T Cell Immunity by Karunarathne, Deshapriya S., Horne-Debets, Joshua M., Huang, Johnny X., Faleiro, Rebecca, Leow, Chiuan Yee, Amante, Fiona, Watkins, Thomas S., Miles, John J., Dwyer, Patrick J., Stacey, Katryn J., Yarski, Michael, Poh, Chek Meng, Lee, Jason S., Cooper, Matthew A., Rénia, Laurent, Richard, Derek, McCarthy, James S., Sharpe, Arlene H., Wykes, Michelle N.

“…Many pathogens, including Plasmodium spp., exploit the interaction of programmed death-1 (PD-1) with PD-1-ligand-1 (PD-L1) to “deactivate” T cell functions,…”
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Malaria drives T cells to exhaustion by Wykes, Michelle N, Horne-Debets, Joshua M, Leow, Chiuan-Yee, Karunarathne, Deshapriya S

“…Malaria is a significant global burden but after >30 years of effort there is no vaccine on the market. While the complex life cycle of the parasite presents…”
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What really happens to dendritic cells during malaria? by Wykes, Michelle N, Good, Michael F

“…The functions of dendritic cells during malaria have been the subject of intensive investigations, the results of which have been controversial. Here, Michelle…”
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Opinion: What really happens to dendritic cells during malaria? by Wykes, Michelle N, Good, Michael F

“…As dendritic cells (DCs) initiate all adaptive and some innate immune responses, it is not surprising that DC function during malaria is the subject of…”
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What have we learnt from mouse models for the study of malaria by Wykes, Michelle N, Good, Michael F

“…Malaria is a serious cause of morbidity and mortality and yet a vaccine is not available. Studies have used animal models to understand the pathogenesis of…”
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ELISPOT Assay to Measure Peptide-specific IFN-γ Production by Wykes, Michelle N, Renia, Laurent

“…Interferon-gamma (IFN-γ) is crucial for immunity against intracellular pathogens and for tumor control. It is produced predominantly by natural killer (NK) and…”
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Long-term antibody memory induced by synthetic peptide vaccination is protective against Streptococcus pyogenes infection and is independent of memory T cell help by Pandey, Manisha, Wykes, Michelle N, Hartas, Jon, Good, Michael F, Batzloff, Michael R

“…Streptococcus pyogenes (group A Streptococcus [GAS]) is a leading human pathogen associated with a diverse array of mucosal and systemic infections…”
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Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity? by Wykes, Michelle N

“…Dendritic cells (DCs), the sentinels of immunity, reside in almost every organ of the body. These cells are responsible for initiating immune responses against…”
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A Peptide-Based PD1 Antagonist Enhances T-Cell Priming and Efficacy of a Prophylactic Malaria Vaccine and Promotes Survival in a Lethal Malaria Model by Phares, Timothy W, Kotraiah, Vinayaka, Karunarathne, Deshapriya S, Huang, Jing, Browne, Cecille D, Buontempo, Peter, Mansour, Marc, Noe, Amy R, Wykes, Michelle N, Pannucci, James, Tsuji, Moriya, Gutierrez, Gabriel M

“…The blockade of programmed cell death-1 (PD1) and its ligand PDL1 has been proven to be a successful immunotherapy against several cancers. Similar to cancer,…”
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Dendritic cells: The Trojan horse of malaria? by Wykes, Michelle N., Horne-Debets, Joshua

“…[Display omitted] ► Life cycle of Plasmodium spp. is more complex than previously appreciated. ► Plasmodium spp. can infect, survive, replicate and escape from…”
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Mice lacking Programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria by Horne-Debets, Joshua M., Karunarathne, Deshapriya S., Faleiro, Rebecca J., Poh, Chek Meng, Renia, Laurent, Wykes, Michelle N.

“…Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density…”
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The Contribution of Co-signaling Pathways to Anti-malarial T Cell Immunity by Faleiro, Rebecca, Karunarathne, Deshapriya S, Horne-Debets, Joshua M, Wykes, Michelle

“…spp., the causative agent of malaria, caused 212 million infections in 2016 with 445,000 deaths, mostly in children. Adults acquire enough immunity to prevent…”
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Development and regulation of cell-mediated immune responses to the blood stages of malaria: implications for vaccine research by Good, Michael F, Xu, Huji, Wykes, Michelle, Engwerda, Christian R

“…The immune response to the malaria parasite is complex and poorly understood. Although antibodies and T cells can control parasite growth in model systems,…”
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Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice by Wykes, Michelle N, Kay, Jason G, Manderson, Anthony, Liu, Xue Q, Brown, Darren L, Richard, Derek J, Wipasa, Jiraprapa, Jiang, Suhua H, Jones, Malcolm K, Janse, Chris J, Waters, Andrew P, Pierce, Susan K, Miller, Louis H, Stow, Jennifer L, Good, Michael F

“…Plasmodium spp. parasites cause malaria in 300 to 500 million individuals each year. Disease occurs during the blood-stage of the parasite's life cycle, where…”
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