Search Results - "Wydra, Roman L."

Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents by Strekowski, Lucjan, Mokrosz, Jerzy L, Honkan, Vidya A, Czarny, Agnieszka, Cegla, Marek T, Wydra, Roman L, Patterson, Steven E, Schinazi, Raymond F

“…Thirty-eight 2-(aryl or heteroaryl)quinolin-4-amines, N,N-disubstituted, N-monosubstituted, and without a substituent at the amino group have been synthesized…”
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DNA sequence dependent binding modes of 4',6-diamidino-2-phenylindole (DAPI) by Wilson, W. David, Tanious, Farial A, Barton, Henryk J, Jones, Robert L, Fox, Keith, Wydra, Roman L, Strekowski, Lucjan

“…The interactions of DAPI with natural DNA and synthetic polymers have been investigated by hydrodynamic, DNase I footprinting, spectroscopic, binding, and…”
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Efficient and Stereoselective Synthesis of 10-Hydroxy-4,8-dimethyldeca-3(E),8(E)-dienoic Acid, a Precursor to (3E,8E)-Suspensolide, Anastrephin, and Epianastrephin by Battiste, Merle A, Wydra, Roman L, Strekowski, Lucjan

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Further studies on the cyclization of aromatic azomethines ortho-substituted with a trifluoromethyl group: synthesis of 2,4-di- or 2,3,4-trisubstituted quinolines by Strekowski, Lucjan, Patterson, Steven E, Janda, Lubomir, Wydra, Roman L, Harden, Donald B, Lipowska, Malgorzata, Cegla, Marek T

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Highly regioselective bromination reactions of polymethylpyrimidines by Strekowski, Lucjan, Wydra, Roman L, Janda, Lubomir, Harden, Donald B

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An unusual base-mediated cyclization of ketimines derived from 2-(trifluoromethyl)aniline that involves the trifluoromethyl group: an expedient route to 2-arylquinolines by Strekowski, Lucjan, Wydra, Roman L, Cegla, Marek T, Czarny, Agnieszka, Harden, Donald B, Patterson, Steven E, Battiste, Merle A, Coxon, James M

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Efficient preparation of ketones from N-(ethoxymethylene)aniline and organometallic reagents by Strekowski, Lucjan, Wydra, Roman L, Cegla, Marek T, Czarny, Agnieszka, Patterson, Steven

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Quantitative structure-activity relationship analysis of cation-substituted polyaromatic compounds as potentiators (amplifiers) of bleomycin-mediated degradation of DNA by Strekowski, Lucjan, Wilson, W. David, Mokrosz, Jerzy L, Mokrosz, Maria J, Harden, Donald B, Tanious, Farial A, Wydra, Roman L, Crow, Sidney A

“…A set of 21 polyheteroaromatic compounds substituted with flexible cationic groups and of similar molecular size has been analyzed for binding with DNA and for…”
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A novel route to 7-(substituted amino)-5,6-dihydrobenz-[c]acridines by STREKOWSKI, L, WYDRA, R. L, HARDEN, D. B, HONKAN, V. A

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Molecular basis for potentiation of bleomycin-mediated degradation of DNA by polyamines. Experimental and molecular mechanical studies by Strekowski, L, Harden, D B, Wydra, R L, Stewart, K D, Wilson, W D

“…The bleomycin-mediated degradation of DNA is stimulated (amplified) by certain DNA binding compounds, such as polyamines, that distort the double helix…”
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A synthetic route to 3-(dialkylamino)phenothiazin-5-ium salts and 3,7-disubstituted derivatives containing two different amino groups by Strekowski, Lucjan, Hou, Dong-Feng, Wydra, Roman L., Schinazi, Raymond F.

“…Phenothiazin‐5‐ium tetraiodide hydrate (2), the suggested oxidation product of phenothiazine with iodine, is treated with two equivalents of a dialkylamine to…”
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An activated trifluoromethyl group as a new synthon for 4,5‐dihydro‐1 H ‐imidazole and 1,4,5,6‐tetrahydropyrimidine systems by Wydra, Roman L., Patterson, Steven E., Strekowski, Lucjan

“…Abstract Treatment of 4‐(trifluoromethyl)benzenamine 1a and 2‐(trifluoromethyl)benzamine 1b with lithium 2‐aminoethylamide gives…”
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An activated trifluoromethyl group as a new synthon for 4,5-dihydro-1H-imidazole and 1,4,5,6-tetrahydropyrimidine systems by Wydra, Roman L., Patterson, Steven E., Strekowski, Lucjan

“…Treatment of 4‐(trifluoromethyl)benzenamine 1a and 2‐(trifluoromethyl)benzamine 1b with lithium 2‐aminoethylamide gives…”
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Synthesis of 2-chloro-4,6-di(heteroaryl)pyrimidines by Strekowski, Lucjan, Harden, Donald B., Grubb III, William B., Patterson, Steven E., Czarny, Agnieszka, Mokrosz, Maria J., Cegla, Marek T., Wydra, Roman L.

“…A practical method for the preparation of 2‐chloro‐4,6‐di(heteroaryl)pyrimidines and their 5‐methyl homologues from readily available 2‐chloropyrimidine and…”
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