Search Results - "Wyatt, Todd A."

Dual Substance Use of Electronic Cigarettes and Alcohol by Wetzel, Tanner J., Wyatt, Todd A.

“…Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long…”
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Post-endotoxin exposure-induced lung inflammation and resolution consequences beneficially impacted by lung-delivered IL-10 therapy by Poole, Jill A., Gaurav, Rohit, Schwab, Aaron, Nelson, Amy J., Gleason, Angela, Romberger, Debra J., Wyatt, Todd A.

“…Although lung diseases typically result from long-term exposures, even a robust, one-time exposure can result in long-lasting consequences. Endotoxin is a…”
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Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation by Warren, Kristi J, Poole, Jill A, Sweeter, Jenea M, DeVasure, Jane M, Dickinson, John D, Peebles, Jr, R Stokes, Wyatt, Todd A

“…Respiratory viral infections are one of the leading causes of need for emergency care and hospitalizations in asthmatic individuals, and airway-secreted…”
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SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts by Muralidharan, Abenaya, Wyatt, Todd A, Reid, St Patrick

“…SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios…”
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High-throughput analysis of lung immune cells in a combined murine model of agriculture dust-triggered airway inflammation with rheumatoid arthritis by Gaurav, Rohit, Mikuls, Ted R, Thiele, Geoffrey M, Nelson, Amy J, Niu, Meng, Guda, Chittibabu, Eudy, James D, Barry, Austin E, Wyatt, Todd A, Romberger, Debra J, Duryee, Michael J, England, Bryant R, Poole, Jill A

“…Rheumatoid arthritis (RA)-associated lung disease is a leading cause of mortality in RA, yet the mechanisms linking lung disease and RA remain unknown. Using…”
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Alcohol, Aldehydes, Adducts and Airways by Sapkota, Muna, Wyatt, Todd A

“…Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins…”
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Effect of epithelial-specific MyD88 signaling pathway on airway inflammatory response to organic dust exposure by Johnson, Amber N., Dickinson, John, Nelson, Amy, Gaurav, Rohit, Kudrna, Katrina, Evans, Scott E., Janike, Katherine, Wyatt, Todd A., Poole, Jill A.

“…The Toll-like receptor (TLR) adaptor protein MyD88 is integral to airway inflammatory response to microbial-enriched organic dust extract (ODE) exposures…”
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Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures by Schwab, Aaron D, Wyatt, Todd A, Moravec, Grace, Thiele, Geoffrey M, Nelson, Amy J, Gleason, Angela, Schanze, Oliver, Duryee, Michael J, Romberger, Debra J, Mikuls, Ted R, Poole, Jill A

“…Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS)…”
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Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust by Warren, Kristi J, Dickinson, John D, Nelson, Amy J, Wyatt, Todd A, Romberger, Debra J, Poole, Jill A

“…Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with…”
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ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia by Samuelson, Derrick R, Smith, Deandra R, Cunningham, Kelly C, Wyatt, Todd A, Hall, Sannette C, Murry, Daryl J, Chhonker, Yashpal S, Knoell, Daren L

“…Pneumococcal pneumonia is a leading cause of morbidity and mortality worldwide. An increased susceptibility is due, in part, to compromised immune function…”
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CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice by McKenzie, Casey W, Craige, Branch, Kroeger, Tiffany V, Finn, Rozzy, Wyatt, Todd A, Sisson, Joseph H, Pavlik, Jacqueline A, Strittmatter, Lara, Hendricks, Gregory M, Witman, George B, Lee, Lance

“…Motile cilia and flagella play critical roles in fluid clearance and cell motility, and dysfunction commonly results in the pediatric syndrome primary ciliary…”
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Lung-delivered IL-10 therapy elicits beneficial effects via immune modulation in organic dust exposure-induced lung inflammation by Schwab, Aaron D, Wyatt, Todd A, Nelson, Amy J, Gleason, Angela, Gaurav, Rohit, Romberger, Debra J, Poole, Jill A

“…Efficacious therapeutic options capable of resolving inflammatory lung disease associated with environmental and occupational exposures are lacking. This study…”
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Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116 by Schneberger, David, DeVasure, Jane M, Kirychuk, Shelley A, Wyatt, Todd A

“…Prolonged exposure to organic barn dusts can lead to chronic inflammation and a broad range of lung problems over time, mediated by innate immune mechanisms…”
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Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance by Warren, Kristi J, Deering-Rice, Cassandra, Huecksteadt, Tom, Trivedi, Shubhanshi, Venosa, Alessandro, Reilly, Christopher, Sanders, Karl, Clayton, Frederic, Wyatt, Todd A, Poole, Jill A, Heller, Nicola M, Leung, Daniel, Paine, 3rd, Robert

“…Asthma is a chronic airway condition that occurs more often in women than men during reproductive years. Population studies have collectively shown that…”
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Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures by Schwab, Aaron D, Nelson, Amy J, Gleason, Angela M, Schanze, Oliver W, Wyatt, Todd A, Shinde, Dhananjay D, Xiao, Peng, Thomas, Vinai C, Guda, Chittibabu, Bailey, Kristina L, Kielian, Tammy, Thiele, Geoffrey M, Poole, Jill A

“…Environmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the…”
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Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice by Poole, Jill A, Mikuls, Ted R, Thiele, Geoffrey M, Gaurav, Rohit, Nelson, Amy J, Duryee, Michael J, Mitra, Ananya, Hunter, Carlos, Wyatt, Todd A, England, Bryant R, Ascherman, Dana P

“…Immunogenetic as well as environmental and occupational exposures have been linked to the development of rheumatoid arthritis (RA), RA-associated lung disease,…”
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Nuclear factor kappa-B contributes to cigarette smoke tolerance in pancreatic ductal adenocarcinoma through cysteine metabolism by Gunda, Venugopal, Chhonker, Yashpal S., Natesh, Nagabhishek Sirpu, Raut, Pratima, Muniyan, Sakthivel, Wyatt, Todd A., Murry, Daryl J., Batra, Surinder K., Rachagani, Satyanarayana

“…Retrospective studies revealed that cigarette smoking enhances risk of incidence and worsens prognosis in pancreatic cancer (PC) patients. Poor prognosis in…”
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Exercise Improves Host Response to Influenza Viral Infection in Obese and Non-Obese Mice through Different Mechanisms by Warren, Kristi J, Olson, Molly M, Thompson, Nicholas J, Cahill, Mackenzie L, Wyatt, Todd A, Yoon, Kyoungjin J, Loiacono, Christina M, Kohut, Marian L

“…Obesity has been associated with greater severity of influenza virus infection and impaired host defense. Exercise may confer health benefits even when weight…”
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Malondialdehyde Acetaldehyde-Adduction Changes Surfactant Protein D Structure and Function by Nissen, Claire G, Mosley, Deanna D, Kharbanda, Kusum K, Katafiasz, Dawn M, Bailey, Kristina L, Wyatt, Todd A

“…Alcohol consumption with concurrent cigarette smoking produces malondialdehyde acetaldehyde (MAA)-adducted lung proteins. Lung surfactant protein D (SPD)…”
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Sex differences in activation of lung-related type 2 innate lymphoid cells in experimental asthma by Warren, Kristi J., PhD, Sweeter, Jenea M., MS, Pavlik, Jacqueline A., BS, Nelson, Amy J., BS, Devasure, Jane M., BS, Dickinson, John D., MD, PhD, Sisson, Joseph H., MD, Wyatt, Todd A., PhD, Poole, Jill A., MD

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