Search Results - "Wyatt, Season K."

Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy by Wyatt, Season K., Witt, Thomas, Barbaro, Nicholas M., Cohen-Gadol, Aaron A., Brewster, Amy L.

“…Microglia-mediated neuroinflammation is widely associated with seizures and epilepsy. Although microglial cells are professional phagocytes, less is known…”
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The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer's Disease by Wyatt-Johnson, Season K, Brutkiewicz, Randy R

“…In the naïve mouse brain, microglia and astrocytes are the most abundant immune cells; however, there is a complexity of other immune cells present including…”
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Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy by Schartz, Nicole D., Wyatt-Johnson, Season K., Price, Lauren R., Colin, Samantha A., Brewster, Amy L.

“…Status epilepticus (SE) triggers a myriad of neurological alterations that include unprovoked seizures, temporal lobe epilepsy (TLE), and cognitive deficits…”
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Status Epilepticus Triggers Time-Dependent Alterations in Microglia Abundance and Morphological Phenotypes in the Hippocampus by Wyatt-Johnson, Season K, Herr, Seth A, Brewster, Amy L

“…Status epilepticus (SE) is defined by the occurrence of prolonged "non-stop" seizures that last for at least 5 min. SE provokes inflammatory responses…”
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Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis by Wyatt-Johnson, Season K, Kersey, Holly N, Codocedo, Juan F, Newell, Kathy L, Landreth, Gary E, Lamb, Bruce T, Oblak, Adrian L, Brutkiewicz, Randy R

“…Neuroinflammation is an important feature of Alzheimer's disease (AD). Understanding which aspects of the immune system are important in AD may lead to new…”
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Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat by Wyatt-Johnson, Season K., Sommer, Alexandra L., Shim, Kevin Y., Brewster, Amy L.

“…Events of status epilepticus (SE) trigger the development of temporal lobe epilepsy (TLE), a type of focal epilepsy that is commonly drug-resistant and is…”
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The immune system in neurological diseases: What innate-like T cells have to say by Wyatt-Johnson, Season K., Afify, Reham, Brutkiewicz, Randy R.

“…The immune system classically consists of 2 lines of defense, innate and adaptive, both of which interact with one another effectively to protect us against…”
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The MR1/MAIT cell axis in CNS diseases by Shrinivasan, Rashmi, Wyatt-Johnson, Season K., Brutkiewicz, Randy R.

“…•The MR1/MAIT cell innate immune axis is understudied in CNS disorders.•Pathology in several CNS diseases involves MR1 and/or MAIT cells.•Elevated of MR1…”
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Enrichment of liver MAIT cells in a mouse model of Alzheimer's disease by Wyatt-Johnson, Season K., Kersey, Holly N., Brutkiewicz, Randy R.

“…Emerging evidence has supported a role for the immune system and liver in Alzheimer's disease (AD). However, our understanding of how hepatic immune cells are…”
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Emerging Roles for Microglial Phagocytic Signaling in Epilepsy by Wyatt-Johnson, Season K., Brewster, Amy L.

“…Microglia are the resident immune cells and professional phagocytes of the central nervous system. However, little is known about the contribution of their…”
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