Search Results - "Wyatt, John S"

Total brain white matter is a major determinant of IQ in adolescents born preterm by Northam, Gemma B., Liégeois, Frédérique, Chong, Wui K., S. Wyatt, John, Baldeweg, Torsten

“…Objective In preterm infants, white matter (WM) abnormalities detected on magnetic resonance imaging (MRI) at term‐age are associated with early developmental…”
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Impaired Autoregulation in Preterm Infants Identified by Using Spatially Resolved Spectroscopy by Wong, Flora Y, Leung, Terence S, Austin, Topun, Wilkinson, Malcolm, Meek, Judith H, Wyatt, John S, Walker, Adrian M

“…The absence of cerebral autoregulation in preterm infants has been associated with adverse outcome, but its bedside assessment in the immature brain is…”
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Determinants of Outcomes After Head Cooling for Neonatal Encephalopathy by Wyatt, John S, Gluckman, Peter D, Liu, Ping Y, Azzopardi, Denis, Ballard, Roberta, Edwards, A. David, Ferriero, Donna M, Polin, Richard A, Robertson, Charlene M, Thoresen, Marianne, Whitelaw, Andrew, Gunn, Alistair J, CoolCap Study Group

“…The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia…”
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Therapeutic Hypothermia Changes the Prognostic Value of Clinical Evaluation of Neonatal Encephalopathy by Gunn, Alistair J., MBChB, PhD, Wyatt, John S., MBBS, MD, Whitelaw, Andrew, MD, Barks, John, MD, Azzopardi, Denis, MD, Ballard, Roberta, MD, Edwards, A. David, FMedSci, Ferriero, Donna M., MD, Gluckman, Peter D., FRS, Polin, Richard A., MD, Robertson, Charlene M., MD, Thoresen, Marianne, MD, PhD

“…Objective To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy. Study design This study was a…”
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Speech and Oromotor Outcome in Adolescents Born Preterm: Relationship to Motor Tract Integrity by Northam, Gemma B., MSc, Liégeois, Frédérique, PhD, Chong, Wui K., FRCR, Baker, Kate, PhD, Tournier, Jacques-Donald, PhD, Wyatt, John S., FRCPCH, Baldeweg, Torsten, MD, Morgan, Angela, PhD

“…Objective To assess speech abilities in adolescents born preterm and investigate whether there is an association between specific speech deficits and brain…”
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Three-dimensional optical tomography of the premature infant brain by Hebden, Jeremy C, Gibson, Adam, Yusof, Rozarina Md, Everdell, Nick, Hillman, Elizabeth M C, Delpy, David T, Arridge, Simon R, Austin, Topun, Meek, Judith H, Wyatt, John S

“…For the first time, three-dimensional images of the newborn infant brain have been generated using measurements of transmitted light. A 32-channel…”
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Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet by Cady, Ernest B, Iwata, Osuke, Bainbridge, Alan, Wyatt, John S, Robertson, Nicola J

“…Phosphorus magnetic resonance spectroscopy (³¹P MRS) often reveals apparently normal brain metabolism in the first hours after intrapartum hypoxia-ischemia…”
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Delayed Whole-Body Cooling to 33 or 35{degrees}C and the Development of Impaired Energy Generation Consequential to Transient Cerebral Hypoxia-Ischemia in the Newborn Piglet by O'Brien, Frances E, Iwata, Osuke, Thornton, John S, Vita, Enrico De, Sellwood, Mark W, Iwata, Sachiko, Sakata, Yasuko S, Charman, Susan, Ordidge, Roger, Cady, Ernest B, Wyatt, John S, Robertson, Nicola J

“…OBJECTIVES. Fundamental questions remain about the precise temperature providing optimal neuroprotection after perinatal hypoxia-ischemia (HI). Furthermore, if…”
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Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia by Iwata, Osuke, Thornton, John S., Sellwood, Mark W., Iwata, Sachiko, Sakata, Yasuko, Noone, Martina A., O'Brien, Frances E., Bainbridge, Alan, De Vita, Enrico, Raivich, Gennadij, Peebles, Donald, Scaravilli, Francesco, Cady, Ernest B., Ordidge, Roger, Wyatt, John S., Robertson, Nicola J.

“…Hypothermia after perinatal hypoxia‐ischemia (HI) is neuroprotective; the precise brain temperature that provides optimal protection is unknown. To assess the…”
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Electrographic seizures are associated with brain injury in newborns undergoing therapeutic hypothermia by Shah, Divyen K, Wusthoff, Courtney J, Clarke, Paul, Wyatt, John S, Ramaiah, Sridhar M, Dias, Ryan J, Becher, Julie-Clare, Kapellou, Olga, Boardman, James P

“…Seizures are common among newborns with hypoxic-ischaemic encephalopathy (HIE) but the relationship between seizure burden and severity of brain injury among…”
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Superficial brain is cooler in small piglets: Neonatal hypothermia implications by Iwata, Sachiko, Iwata, Osuke, Thornton, John S., Shanmugalingam, Shanthi, Bainbridge, Alan, Peebles, Donald, Wyatt, John S., Cady, Ernest B., Robertson, Nicola J.

“…Objective Hypothermia was not neuroprotective in low body weight (BW) infants on subgroup analysis in a recent clinical trial of selective head cooling (SHC)…”
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Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial by Gluckman, Peter D, Wyatt, John S, Azzopardi, Denis, Ballard, Roberta, Edwards, A David, Ferriero, Donna M, Polin, Richard A, Robertson, Charlene M, Thoresen, Marianne, Whitelaw, Andrew, Gunn, Alistair J

“…Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-ischaemia. We did a multicentre randomised controlled trial to find out if delayed…”
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Interhemispheric temporal lobe connectivity predicts language impairment in adolescents born preterm by Northam, Gemma B., Liégeois, Frédérique, Tournier, Jacques-Donald, Croft, Louise J., Johns, Paul N., Chong, Wui K., Wyatt, John S., Baldeweg, Torsten

“…Although language difficulties are common in children born prematurely, robust neuroanatomical correlates of these impairments remain to be established. This…”
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Synergy between antenatal exposure to infection and intrapartum events in causation of perinatal brain injury at term by Peebles, Donald M., Wyatt, John S.

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Brain and cognitive-behavioural development after asphyxia at term birth by De Haan, Michelle, Wyatt, John S., Roth, Simon, Vargha-Khadem, Faraneh, Gadian, David, Mishkin, Mortimer

“…Perinatal asphyxia occurs in approximately 1–6 per 1000 live full‐term births. Different patterns of brain damage can result, though the relation of these…”
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Ethics and hypothermia treatment by Wyatt, John S

“…Summary Hypothermia is the first effective neuroprotective intervention for newborns who are critically ill following a life-threatening asphyxial insult. It…”
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“Therapeutic time window” duration decreases with increasing severity of cerebral hypoxia–ischaemia under normothermia and delayed hypothermia in newborn piglets by Iwata, Osuke, Iwata, Sachiko, Thornton, John S, De Vita, Enrico, Bainbridge, Alan, Herbert, Linda, Scaravilli, Francesco, Peebles, Donald, Wyatt, John S, Cady, Ernest B, Robertson, Nicola J

“…Abstract Objective: For optimal neuroprotection following transient perinatal hypoxia–ischaemia (HI), therapy should start before overt secondary energy…”
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Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography by Hebden, Jeremy C, Gibson, Adam, Austin, Topun, Yusof, Rozarina Md, Everdell, Nick, Delpy, David T, Arridge, Simon R, Meek, Judith H, Wyatt, John S

“…Induced haemodynamic and blood oxygenation changes occurring within the brain of a ventilated newborn infant have been imaged in three dimensions using optical…”
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Comparative Prognostic Utilities of Early Quantitative Magnetic Resonance Imaging Spin-Spin Relaxometry and Proton Magnetic Resonance Spectroscopy in Neonatal Encephalopathy by Shanmugalingam, Shanthi, Thornton, John S, Iwata, Osuke, Bainbridge, Alan, O'Brien, Frances E, Priest, Andrew N, Ordidge, Roger J, Cady, Ernest B, Wyatt, John S, Robertson, Nicola J

“…We sought to compare the prognostic utilities of early MRI spin-spin relaxometry and proton magnetic resonance spectroscopy in neonatal encephalopathy…”
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Predictors of Long-Term Outcome in Very Preterm Infants: Gestational Age Versus Neonatal Cranial Ultrasound by Vollmer, Brigitte, Roth, Simon, Baudin, Jenny, Stewart, Ann L, Neville, Brian G. R, Wyatt, John S

“…To investigate the effect of gestational age at birth on the frequency of ultrasound-detected brain lesions in infants born at <33 weeks of gestation and to…”
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