Search Results - "Wutz, Johannes"

Establishment of a CFD‐based kLa model in microtiter plates to support CHO cell culture scale‐up during clone selection by Wutz, Johannes, Steiner, Robin, Assfalg, Kerstin, Wucherpfennig, Thomas

“…Microtiter plates are a common tool for clone selection in biopharmaceutical development. A way of visualizing and evaluating these systems and key processes…”
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CFD supported scale up of perfusion bioreactors in biopharma by Kuschel, Maike, Wutz, Johannes, Salli, Mustafa, Monteil, Dominique, Wucherpfennig, Thomas

“…The robust scale up of perfusion systems requires comparable conditions over all scales to ensure equivalent cell culture performance. As cells in continuous…”
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Modeling mass transfer in stirred microbioreactors by Farsani, Hooman Yadollahi, Wutz, Johannes, DeVincentis, Brian, Thomas, John A., Motevalian, Seyed Pouria

“…•Systematic/mechanistic modeling approach for bioreactor characterization is presented.•Gas transfer contributions from free surface and individual bubbles are…”
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Computational fluid dynamics (CFD) as a tool for industrial UF/DF tank optimization by Wutz, Johannes, Waterkotte, Björn, Heitmann, Kai, Wucherpfennig, Thomas

“…[Display omitted] •Mixing tanks can be characterized using computational fluid dynamics CFD.•Prediction of complex behavior caused by stirring in combination…”
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Predicting the diameters of droplets produced in turbulent liquid–liquid dispersion by Thomas, John A., DeVincentis, Brian, Wutz, Johannes, Ricci, Francesco

“…The droplet size distribution in liquid–liquid dispersions is a complex convolution of impeller speed, impeller type, fluid properties, and flow conditions. In…”
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Characterization of hydrodynamic stress in ambr250® bioreactor system and its impact on mammalian cell culture by Šrom, Ondřej, Trávníková, Veronika, Wutz, Johannes, Kuschel, Maike, Unsoeld, Andreas, Wucherpfennig, Thomas, Šoóš, Miroslav

“…During the cell culture in stirred aerated vessels, both stirring and sparging is required for proper homogenization of a mixture and oxygen delivery. Quality…”
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Establishment of a CFD-based k L a model in microtiter plates to support CHO cell culture scale-up during clone selection by Wutz, Johannes, Steiner, Robin, Assfalg, Kerstin, Wucherpfennig, Thomas

“…Microtiter plates are a common tool for clone selection in biopharmaceutical development. A way of visualizing and evaluating these systems and key processes…”
Get full text

A Novel MATLAB®-Algorithm-Based Video Analysis to Quantitatively Determine Solution Creeping in Intact Pharmaceutical Glass Vials by Molnar, Daniel, Röhm, Martina, Wutz, Johannes, Rivec, Ingrid, Michel, Annika, Klotz, Gina, Hubbuch, Jürgen, Schindowski, Katharina, Presser, Ingo

“…[Display omitted] During the filling process of a biopharmaceutical drug product (DP), a liquid DP film might creep up the inner vial wall which is barely…”
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Modeling free surface gas transfer in agitated lab-scale bioreactors by Thomas, John A., Rahman, Anisur, Wutz, Johannes, Wang, Ying, DeVincentis, Brian, McGuire, Brendan, Cao, Lei

“…A physics-based approach for modeling convective gas-liquid mass transfer across free surfaces in lab-scale agitated vessels is presented. This approach, which…”
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Influence of Spacing of Multiple Impellers on Power Input in an Industrial‐Scale Aerated Stirred Tank Reactor by Fitschen, Jürgen, Maly, Marc, Rosseburg, Annika, Wutz, Johannes, Wucherpfennig, Thomas, Schlüter, Michael

“…Despite the fact that aerated stirred tank reactors are widely used in industry and often studied, their design and scale‐up still remains challenging…”
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Establishment of a CFD-based kL a model in microtiter plates to support CHO cell culture scale-up during clone selection by Wutz, Johannes, Steiner, Robin, Assfalg, Kerstin, Wucherpfennig, Thomas

“…Microtiter plates are a common tool for clone selection in biopharmaceutical development. A way of visualizing and evaluating these systems and key processes…”
Get full text