Search Results - "Wurtman, R."

Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils by Cansev, M, Wurtman, R.J

“…Abstract Synthesis of phosphatidylcholine, the most abundant brain membrane phosphatide, requires three circulating precursors: choline; a pyrimidine (e.g…”
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Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides by Wurtman, Richard J., Cansev, M., Ulus, I. H.

“…Objective The loss of cortical and hippocampal synapses is a universal hallmark of Alzheimer’s disease, and probably underlies its effects on cognition…”
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Uridine enhances neurite outgrowth in nerve growth factor-differentiated pheochromocytoma cells by Pooler, A.M., Guez, D.H., Benedictus, R., Wurtman, R.J.

“…During rapid cell growth the availability of phospholipid precursors like cytidine triphosphate and diacylglycerol can become limiting in the formation of key…”
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Nutrition and Alzheimer's disease: pre-clinical concepts by Kamphuis, P. J., Wurtman, R. J.

“…Alzheimer’s disease (AD) is a progressive condition characterized by neurodegeneration and the dense deposition of proteins in the brain. There is no cure for…”
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Effect of Inducing Nocturnal Serum Melatonin Concentrations in Daytime on Sleep, Mood, Body Temperature, and Performance by Dollins, Andrew B., Zhdanova, Irina V., Wurtman, Richard J., Lynch, Harry J., Deng, Mei H.

“…We examined effects of very low doses of melatonin (0.1-10 mg, orally) or placebo, administered at 1145 h, on sleep latency and duration, mood, performance,…”
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Evidence for a Membrane Defect in Alzheimer Disease Brain by Nitsch, Roger M., Blusztajn, Jan K., Pittas, Anastassios G., Slack, Barbara E., Growdon, John H., Wurtman, Richard J.

“…To determine whether neurodegeneration in Alzheimer disease brain is associated with degradation of structural cell membrane molecules, we measured tissue…”
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Genes, stress, and depression by Wurtman, Richard J.

“…A relationship between genetic makeup and susceptibility to major depressive disorder (MDD) has long been suspected on the basis of family and twin studies. A…”
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Choline metabolism as a basis for the selective vulnerability of cholinergic neurons by Wurtman, R J

“…The unique propensity of cholinergic neurons to use choline for two purposes--ACh and membrane phosphatidylcholine synthesis--may contribute to their selective…”
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Activation of protein kinase C inhibits cellular production of the amyloid beta-protein by HUNG, A. Y, HAASS, C, NITSCH, R. M, WEI QIAO QIU, CITRON, M, WURTMAN, R. J, GROWDON, J. H, SELKOE, D. J

“…The 39-43-amino acid amyloid beta-protein (A beta), which is progressively deposited in cerebral plaques and blood vessels in Alzheimer's disease (AD), is…”
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Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans by ZHDANOVA, I. V, WURTMAN, R. J, MORABITO, C, PIOTROVSKA, V. R, LYNCH, H. J

“…Low oral doses of melatonin raise serum melatonin concentrations to those normally occurring nocturnally and facilitate polysomnographically assessed sleep…”
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Melatonin: A sleep-promoting hormone by ZHDANOVA, I. V, LYNCH, H. J, WURTMAN, R. J

“…This review discusses the issue of a dual effect of melatonin on sleep: acute sleep promotion that typically occurs within one hour of administration, and the…”
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Effects of phentermine on striatal dopamine and serotonin release in conscious rats : In vivo microdialysis study by BALCIOGLU, A, WURTMAN, R. J

“…To measure the effects of phentermine, an appetite supressant, on the release of brain dopamine (DA) and serotonin (5-HT) into striatal dialysates of freely…”
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Sleep-inducing effects of low doses of melatonin ingested in the evening by Zhdanova, I V, Wurtman, R J, Lynch, H J, Ives, J R, Dollins, A B, Morabito, C, Matheson, J K, Schomer, D L

“…We previously observed tht low oral doses of melatonin given at noon increase blood melatonin concentrations to those normally occurring nocturnally and…”
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Release of Amyloid β-Protein Precursor Derivatives by Electrical Depolarization of Rat Hippocampal Slices by Nitsch, Roger M., Farber, Steven A., Growdon, John H., Wurtman, Richard J.

“…Proteolytic processing of the β-amyloid protein precursor (APP) is regulated by cell-surface receptors. To determine whether neurotransmitter release in…”
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Melatonin treatment for age-related insomnia by ZHDANOVA, Irina V, WURTMAN, Richard J, REGAN, Meredith M, TAYLOR, Judith A, JIAN PING SHI, LECLAIR, Ojingwa U

“…Older people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to younger…”
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Amyloid Precursor Protein Processing is Stimulated by Metabotropic Glutamate Receptors by Robert K. K. Lee, Wurtman, Richard J., Cox, Alice J., Nitsch, Roger M.

“…Stimulation of muscarinic m1 or m3 receptors can, by generating diacylglycerol and activating protein kinase C, accelerate the breakdown of the amyloid…”
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An animal model of antipsychotic-induced weight gain by Arjona, Anibal A, Zhang, Sandy X, Adamson, Brittany, Wurtman, Richard J

“…We have established an animal model for olanzapine-induced body weight gain, and used it to explore the relation between this weight gain, excessive food…”
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Sibutramine, a serotonin uptake inhibitor, increases dopamine concentrations in rat striatal and hypothalamic extracellular fluid by Balcioglu, Aygul, Wurtman, Richard J

“…We measured, using microdialysis, the effects of sibutramine, given intraperitoneally, on brain dopamine and serotonin flux into striatal and hypothalamic…”
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Effects of systemic nicotine on serotonin release in rat brain by Ribeiro, E B, Bettiker, R L, Bogdanov, M, Wurtman, R J

“…We used in vivo microdialysis to examine the acute effects of systemically administered nicotine (0.8-8.0 mg/kg, s.c.) on extracellular levels of serotonin…”
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Endogenous Melatonin Levels and the Fate of Exogenous Melatonin: Age Effects by Zhdanova, Irina V., Wurtman, Richard J., Balcioglu, Aygul, Kartashov, Alex I., Lynch, Harry J.

“…This study examines the range of serum melatonin concentrations that occur among young and older adults, and tests the effects of orally administered melatonin…”
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