Search Results - "Wurm, Jan"

The structure of the SAM/SAH-binding riboswitch by Weickhmann, A Katharina, Keller, Heiko, Wurm, Jan P, Strebitzer, Elisabeth, Juen, Michael A, Kremser, Johannes, Weinberg, Zasha, Kreutz, Christoph, Duchardt-Ferner, Elke, Wöhnert, Jens

“…Abstract S-adenosylmethionine (SAM) is a central metabolite since it is used as a methyl group donor in many different biochemical reactions. Many bacteria…”
Get full text

What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch by Duchardt-Ferner, Elke, Gottstein-Schmidtke, Sina R., Weigand, Julia E., Ohlenschläger, Oliver, Wurm, Jan-Philip, Hammann, Christian, Suess, Beatrix, Wöhnert, Jens

“…To ensure appropriate metabolic regulation, riboswitches must discriminate efficiently between their target ligands and chemically similar molecules that are…”
Get full text

Structural and functional analysis of the archaeal endonuclease Nob1 by Veith, Thomas, Martin, Roman, Wurm, Jan P, Weis, Benjamin L, Duchardt-Ferner, Elke, Safferthal, Charlotta, Hennig, Raoul, Mirus, Oliver, Bohnsack, Markus T, Wöhnert, Jens, Schleiff, Enrico

“…Eukaryotic ribosome biogenesis requires the concerted action of numerous ribosome assembly factors, for most of which structural and functional information is…”
Get full text

Wood-Veneer-Reinforced Mycelium Composites for Sustainable Building Components by Özdemir, Eda, Saeidi, Nazanin, Javadian, Alireza, Rossi, Andrea, Nolte, Nadja, Ren, Shibo, Dwan, Albert, Acosta, Ivan, Hebel, Dirk E, Wurm, Jan, Eversmann, Philipp

“…The demand for building materials has been constantly increasing, which leads to excessive energy consumption for their provision. The looming environmental…”
Get full text

Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS by Hacker, Carolin, Cai, Xiaofeng, Kegler, Carsten, Zhao, Lei, Weickhmann, A. Katharina, Wurm, Jan Philip, Bode, Helge B., Wöhnert, Jens

“…Several peptides in clinical use are derived from non-ribosomal peptide synthetases (NRPS). In these systems multiple NRPS subunits interact with each other in…”
Get full text

Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex by Wurm, Jan Philip, Sung, Sihyun, Kneuttinger, Andrea Christa, Hupfeld, Enrico, Sterner, Reinhard, Wilmanns, Matthias, Sprangers, Remco

“…Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is responsible for…”
Get full text

Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans by Meyer, Britta, Wurm, Jan Philip, Sharma, Sunny, Immer, Carina, Pogoryelov, Denys, Kötter, Peter, Lafontaine, Denis L J, Wöhnert, Jens, Entian, Karl-Dieter

“…The chemically most complex modification in eukaryotic rRNA is the conserved hypermodified nucleotide N1-methyl-N3-aminocarboxypropyl-pseudouridine…”
Get full text

An intermolecular G-quadruplex as the basis for GTP recognition in the class V-GTP aptamer by Nasiri, Amir H, Wurm, Jan Philip, Immer, Carina, Weickhmann, Anna Katharina, Wöhnert, Jens

“…Many naturally occurring or artificially created RNAs are capable of binding to guanine or guanine derivatives with high affinity and selectivity. They bind…”
Get full text

ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase by Wurm, Jan Philip, Meyer, Britta, Bahr, Ute, Held, Martin, Frolow, Olga, Kötter, Peter, Engels, Joachim W, Heckel, Alexander, Karas, Michael, Entian, Karl-Dieter, Wöhnert, Jens

“…Nep1 (Emg1) is a highly conserved nucleolar protein with an essential function in ribosome biogenesis. A mutation in the human Nep1 homolog causes…”
Get full text

Structural basis for RNA-duplex unwinding by the DEAD-box helicase DbpA by Wurm, Jan Philip

“…DEAD-box RNA helicases are implicated in most aspects of RNA biology, where these enzymes unwind short RNA duplexes in an ATP-dependent manner. During the…”
Get full text

Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8‑Barrel Enzyme of Histidine Biosynthesis HisF by Hupfeld, Enrico, Schlee, Sandra, Wurm, Jan Philip, Rajendran, Chitra, Yehorova, Dariia, Vos, Eva, Ravindra Raju, Dinesh, Kamerlin, Shina Caroline Lynn, Sprangers, Remco, Sterner, Reinhard

“…The overall significance of loop motions for enzymatic activity is generally accepted. However, it has largely remained unclear whether and how such motions…”
Get full text

Essential ribosome assembly factor Fap7 regulates a hierarchy of RNA–protein interactions during small ribosomal subunit biogenesis by Hellmich, Ute A., Weis, Benjamin L., Lioutikov, Anatoli, Wurm, Jan Philip, Kaiser, Marco, Christ, Nina A., Hantke, Katharina, Kötter, Peter, Entian, Karl-Dieter, Schleiff, Enrico, Wöhnert, Jens

“…Factor activating Pos9 (Fap7) is an essential ribosome biogenesis factor important for the assembly of the small ribosomal subunit with an uncommon dual ATPase…”
Get full text

Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms by Wurm, Jan Philip, Sprangers, Remco

“…[Display omitted] •Structure of the active state of the Dcp2 decapping enzyme.•Insights into the structural states that are sampled in solution.•Details…”
Get full text

Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus by Kaiser, Marco, Wurm, Jan Philip, Märtens, Birgit, Bläsi, Udo, Pogoryelov, Denys, Wöhnert, Jens

“…During translation initiation, the heterotrimeric archaeal translation initiation factor 2 (aIF2) recruits the initiator tRNAi to the small ribosomal subunit…”
Get full text

Backbone and side chain NMR assignments for the ribosome assembly factor Nop6 from Saccharomyces cerevisiae by Wurm, Jan Philip, Lioutikov, Anatoli, Kötter, Peter, Entian, Karl-Dieter, Wöhnert, Jens

“…The Saccharomyces cerevisiae Nop6 protein is involved in the maturation of the small ribosomal subunit. It contains a central RNA binding domain and a…”
Get full text

Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs by Wurm, Jan Philip, Griese, Marco, Bahr, Ute, Held, Martin, Heckel, Alexander, Karas, Michael, Soppa, Jörg, Wöhnert, Jens

“…tRNAs from all three kingdoms of life contain a variety of modified nucleotides required for their stability, proper folding, and accurate decoding. One…”
Get full text

Leotard by Wurm, Jan

Get full text

Assignment of the Ile, Leu, Val, Met and Ala methyl group resonances of the DEAD-box RNA helicase DbpA from E. coli by Wurm, Jan Philip

“…ATP-dependent DEAD-box helicases constitute one of the largest families of RNA helicases and are important regulators of most RNA-dependent cellular processes…”
Get full text

The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface by Wurm, Jan Philip, Overbeck, Jan, Sprangers, Remco

“…The removal of the 5' 7-methylguanosine mRNA cap structure (decapping) is a central step in the 5'-3' mRNA degradation pathway and is performed by the…”
Get full text

Insights into the Structure of Invisible Conformations of Large Methyl Group Labeled Molecular Machines from High Pressure NMR by Krempl, Christina, Wurm, Jan Philip, Beck Erlach, Markus, Kremer, Werner, Sprangers, Remco

“…[Display omitted] •High pressure NMR can be applied to large methyl labeled protein complexes.•The equilibrium between the closed and the open conformation of…”
Get full text