Search Results - "Wurm, Alexander A."

Long Non-coding RNAs as Functional and Structural Chromatin Modulators in Acute Myeloid Leukemia by Wurm, Alexander A., Pina, Cristina

“…Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the…”
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Incubation of Immune Cell Grafts With MAX.16H5 IgG1 Anti-Human CD4 Antibody Prolonged Survival After Hematopoietic Stem Cell Transplantation in a Mouse Model for Fms Like Tyrosine Kinase 3 Positive Acute Myeloid Leukemia by Hilger, Nadja, Mueller, Claudia, Stahl, Lilly, Mueller, Anne M, Zoennchen, Bianca, Dluczek, Sarah, Halbich, Christoph, Wickenhauser, Claudia, Gerloff, Dennis, Wurm, Alexander A, Behre, Gerhard, Kretschmer, Anna, Fricke, Stephan

“…Despite the constant development of innovative therapeutic options for hematological malignancies, the gold-standard therapy regimen for curative treatment…”
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BRAF and MEK inhibitor combinations induce potent molecular and immunological effects in NRAS‐mutant melanoma cells: Insights into mode of action and resistance mechanisms by Dinter, Lisa, Karitzky, Paula C., Schulz, Alexander, Wurm, Alexander A., Mehnert, Marie‐Christin, Sergon, Mildred, Tunger, Antje, Lesche, Mathias, Wehner, Rebekka, Müller, Anja, Käubler, Theresa, Niessner, Heike, Dahl, Andreas, Beissert, Stefan, Schmitz, Marc, Meier, Friedegund, Seliger, Barbara, Westphal, Dana

“…About 25% of melanoma harbor activating NRAS mutations, which are associated with aggressive disease therefore requiring a rapid antitumor intervention…”
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The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision by Herbst, Friederike, Lang, Tonio J. L., Eckert, Elias S. P., Wünsche, Peer, Wurm, Alexander A., Kindinger, Tim, Laaber, Karin, Hemmati, Shayda, Hotz-Wagenblatt, Agnes, Zavidij, Oksana, Paruzynski, Anna, Lu, Junyan, von Kalle, Christof, Zenz, Thorsten, Klein, Christoph, Schmidt, Manfred, Ball, Claudia R., Glimm, Hanno

“…Protein-coding and non-coding genes like miRNAs tightly control hematopoietic differentiation programs. Although miRNAs are frequently located within introns…”
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EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors by Zjablovskaja, Polina, Kardosova, Miroslava, Danek, Petr, Angelisova, Pavla, Benoukraf, Touati, Wurm, Alexander A, Kalina, Tomas, Sian, Stephanie, Balastik, Martin, Delwel, Ruud, Brdicka, Tomas, Tenen, Daniel G, Behre, Gerhard, Fiore, Fréderic, Malissen, Bernard, Horejsi, Vaclav, Alberich-Jorda, Meritxell

“…Development of hematopoietic populations through the process of differentiation is critical for proper hematopoiesis. The transcription factor CCAAT/enhancer…”
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MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia by Hartmann, Jens-Uwe, Bräuer-Hartmann, Daniela, Kardosova, Miroslava, Wurm, Alexander A., Wilke, Franziska, Schödel, Cindy, Gerloff, Dennis, Katzerke, Christiane, Krakowsky, Rosanna, Namasu, Carolina Yaeko, Bill, Marius, Schwind, Sebastian, Müller-Tidow, Carsten, Niederwieser, Dietger, Alberich-Jorda, Meritxell, Behre, Gerhard

“…Hematopoiesis, the formation of blood cells from hematopoietic stem cells (HSC), is a highly regulated process. Since the discovery of microRNAs (miRNAs),…”
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Correction to: EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors by Zjablovskaja, Polina, Kardosova, Miroslava, Danek, Petr, Angelisova, Pavla, Benoukraf, Touati, Wurm, Alexander A., Kalina, Tomas, Sian, Stephanie, Balastik, Martin, Delwel, Ruud, Brdicka, Tomas, Tenen, Daniel G., Behre, Gerhard, Fiore, Fréderic, Malissen, Bernard, Horejsi, Vaclav, Alberich-Jorda, Meritxell

“…Since publication of this article, the authors identified an error in the acknowledgments section. The original sentence in acknowledgments reads as follows:…”
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Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity by Wurm, Alexander A., Brilloff, Silke, Kolovich, Sofia, Schäfer, Silvia, Rahimian, Elahe, Kufrin, Vida, Bill, Marius, Carrero, Zunamys I., Drukewitz, Stephan, Krüger, Alexander, Hüther, Melanie, Uhrig, Sebastian, Oster, Sandra, Westphal, Dana, Meier, Friedegund, Pfütze, Katrin, Hübschmann, Daniel, Horak, Peter, Kreutzfeldt, Simon, Richter, Daniela, Schröck, Evelin, Baretton, Gustavo, Heining, Christoph, Möhrmann, Lino, Fröhling, Stefan, Ball, Claudia R., Glimm, Hanno

“…Targeted therapies are effective in treating cancer, but success depends on identifying cancer vulnerabilities. In our study, we utilize small RNA sequencing…”
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miR-451a abrogates treatment resistance in FLT3-ITD-positive acute myeloid leukemia by Krakowsky, Rosanna H. E., Wurm, Alexander A., Gerloff, Dennis, Katzerke, Christiane, Bräuer-Hartmann, Daniela, Hartmann, Jens-Uwe, Wilke, Franziska, Thiede, Christian, Müller-Tidow, Carsten, Niederwieser, Dietger, Behre, Gerhard

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PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia by Bräuer-Hartmann, Daniela, Hartmann, Jens-Uwe, Wurm, Alexander Arthur, Gerloff, Dennis, Katzerke, Christiane, Verga Falzacappa, Maria Vittoria, Pelicci, Pier Giuseppe, Müller-Tidow, Carsten, Tenen, Daniel G, Niederwieser, Dietger, Behre, Gerhard

“…In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. microRNAs…”
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EVI2B is a C/EBP alpha target gene required for granulocytic differentiation and functionality of hematopoietic progenitors (vol 24, pg 705, 2017) by Zjablovskaja, Polina, Kardosova, Miroslava, Danek, Petr, Angelisova, Pavla, Benoukraf, Touati, Wurm, Alexander A., Kalina, Tomas, Sian, Stephanie, Balastik, Martin, Delwel, Ruud, Brdicka, Tomas, Tenen, Daniel G., Behre, Gerhard, Fiore, Frederic, Malissen, Bernard, Horejsi, Vaclav, Alberich-Jorda, Meritxell

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EVI2B is a C/EBP[alpha] target gene required for granulocytic differentiation and functionality of hematopoietic progenitors by Zjablovskaja, Polina, Kardosova, Miroslava, Danek, Petr, Angelisova, Pavla, Benoukraf, Touati, Wurm, Alexander A, Kalina, Tomas, Sian, Stephanie, Balastik, Martin, Delwel, Ruud, Brdicka, Tomas, Tenen, Daniel G, Behre, Gerhard, Fiore, Fréderic, Malissen, Bernard, Horejsi, Vaclav, Alberich-jorda, Meritxell

“…Development of hematopoietic populations through the process of differentiation is critical for proper hematopoiesis. The transcription factor CCAAT/enhancer…”
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Validation of the Revised 2022 European LeukemiaNet Risk Stratification in Adult Patients with Acute Myeloid Leukemia by Ruhnke, Leo, Bill, Marius, Zukunft, Sven, Eckardt, Jan-Niklas, Schäfer, Silvia, Stasik, Sebastian, Hanoun, Maher, Schroeder, Thomas, Fransecky, Lars, Steffen, Björn, Krause, Stefan W, Scholl, Sebastian, Hochhaus, Andreas, Sauer, Tim, Kraus, Sabrina, Schäfer-Eckart, Kerstin, Kaufmann, Martin, Jost, Edgar, Brümmendorf, Tim H., Schliemann, Christoph, Mikesch, Jan-Henrik, Krug, Utz, Hänel, Mathias, Morgner, Anke, Schaich, Markus, Neubauer, Andreas, Repp, Roland, Niemann, Dirk, Seggewiss-Bernhardt, Ruth, Meinhardt, Achim, Kullmer, Johannes, Kaiser, Ulrich, Blau, Wolfgang, Kiani, Alexander, Grigoleit, Götz Ulrich, Giagounidis, Aristoteles, Wurm, Alexander Arthur, Altmann, Heidi, Middeke, Jan Moritz M, Schetelig, Johannes, Müller-Tidow, Carsten, Stölzel, Friedrich, Baldus, Claudia D., Platzbecker, Uwe, Serve, Hubert, Bornhäuser, Martin, Thiede, Christian, Röllig, Christoph

“…In 2022, the European LeukemiaNet (ELN) risk stratification for patients with AML has been updated. We aimed to validate the prognostic value of the 2022 ELN…”
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Abstract 4110: Pathway activation driven miRNA depletion highlights cancer signaling vulnerabilities and targeted therapy sensitivity by Wurm, Alexander A., Brilloff, Silke, Carrero, Zunamys I., Drukewitz, Stephan, Krüger, Alexander, Oster, Sandra, Kolovich, Sofia, Hüther, Melanie, Uhrig, Sebastian, Westphal, Dana, Meier, Friedegund, Pfütze, Katrin, Hübschmann, Daniel, Horak, Peter, Kreutzfeldt, Simon, Heining, Christoph, Richter, Daniela, Fröhling, Stefan, Ball, Claudia R., Glimm, Hanno

“…Abstract Identification of cancer vulnerabilities is pivotal for the success of precision oncology. Comprehensive molecular profiling technologies improved…”
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