Search Results - "Wullimann, David"

Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial by Bergman, Peter, Blennow, Ola, Hansson, Lotta, Mielke, Stephan, Nowak, Piotr, Chen, Puran, Söderdahl, Gunnar, Österborg, Anders, Smith, C. I. Edvard, Wullimann, David, Vesterbacka, Jan, Lindgren, Gustaf, Blixt, Lisa, Friman, Gustav, Wahren-Borgström, Emilie, Nordlander, Anna, Gomez, Angelica Cuapio, Akber, Mira, Valentini, Davide, Norlin, Anna-Carin, Thalme, Anders, Bogdanovic, Gordana, Muschiol, Sandra, Nilsson, Peter, Hober, Sophia, Loré, Karin, Chen, Margaret Sällberg, Buggert, Marcus, Ljunggren, Hans-Gustaf, Ljungman, Per, Aleman, Soo

“…Patients with immunocompromised disorders have mainly been excluded from clinical trials of vaccination against COVID-19. Thus, the aim of this prospective…”
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T-cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial by Blixt, Lisa, Wullimann, David, Aleman, Soo, Lundin, Jeanette, Chen, Puran, Gao, Yu, Cuapio, Angelica, Akber, Mira, Lange, Joshua, Rivera-Ballesteros, Olga, Buggert, Marcus, Ljunggren, Hans-Gustaf, Hansson, Lotta, Österborg, Anders

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MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine by Boulouis, Caroline, Kammann, Tobias, Cuapio, Angelica, Parrot, Tiphaine, Gao, Yu, Mouchtaridi, Elli, Wullimann, David, Lange, Joshua, Chen, Puran, Akber, Mira, Rivera Ballesteros, Olga, Muvva, Jagadeeswara Rao, Smith, C I Edvard, Vesterbacka, Jan, Kieri, Oscar, Nowak, Piotr, Bergman, Peter, Buggert, Marcus, Ljunggren, Hans-Gustaf, Aleman, Soo, Sandberg, Johan K

“…Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like capacity to rapidly respond to microbial infection via MR1-restricted…”
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Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia by Ingelman-Sundberg, Hanna M, Blixt, Lisa, Wullimann, David, Wu, Jinghua, Gao, Yu, Healy, Katie, Muschiol, Sandra, Bogdanovic, Gordana, Åberg, Mikael, Kjellander, Christian, Grifoni, Alba, Sette, Alessandro, Aleman, Soo, Chen, Puran, Blennow, Ola, Hansson, Lotta, Ljunggren, Hans-Gustaf, Chen, Margaret Sällberg, Buggert, Marcus, Österborg, Anders

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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 by Sekine, Takuya, Perez-Potti, André, Rivera-Ballesteros, Olga, Strålin, Kristoffer, Gorin, Jean-Baptiste, Olsson, Annika, Llewellyn-Lacey, Sian, Kamal, Habiba, Bogdanovic, Gordana, Muschiol, Sandra, Wullimann, David J., Kammann, Tobias, Emgård, Johanna, Parrot, Tiphaine, Folkesson, Elin, Akber, Mira, Berglin, Lena, Bergsten, Helena, Brighenti, Susanna, Brownlie, Demi, Butrym, Marta, Chambers, Benedict, Chen, Puran, Jeannin, Martin Cornillet, Grip, Jonathan, Gomez, Angelica Cuapio, Dillner, Lena, Lozano, Isabel Diaz, Dzidic, Majda, Tullberg, Malin Flodström, Färnert, Anna, Glans, Hedvig, Haroun-Izquierdo, Alvaro, Henriksson, Elizabeth, Hertwig, Laura, Kalsum, Sadaf, Kokkinou, Efthymia, Kvedaraite, Egle, Loreti, Marco, Lourda, Magalini, Maleki, Kimia, Malmberg, Karl-Johan, Marquardt, Nicole, Maucourant, Christopher, Michaelsson, Jakob, Mjösberg, Jenny, Moll, Kirsten, Muva, Jagadees, Mårtensson, Johan, Nauclér, Pontus, Norrby-Teglund, Anna, Medina, Laura Palma, Persson, Björn, Radler, Lena, Ringqvist, Emma, Sandberg, John Tyler, Sohlberg, Ebba, Soini, Tea, Svensson, Mattias, Tynell, Janne, Varnaite, Renata, Kries, Andreas Von, Unge, Christian, Rooyackers, Olav, Eriksson, Lars I., Henter, Jan-Inge, Sönnerborg, Anders, Allander, Tobias, Albert, Jan, Nielsen, Morten, Klingström, Jonas, Gredmark-Russ, Sara, Björkström, Niklas K., Sandberg, Johan K., Price, David A., Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus

“…SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional…”
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Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity by Kvedaraite, Egle, Hertwig, Laura, Sinha, Indranil, Ponzetta, Andrea, Myrberg, Ida Hed, Lourda, Magda, Dzidic, Majda, Akber, Mira, Klingström, Jonas, Folkesson, Elin, Muvva, Jagadeeswara Rao, Chen, Puran, Gredmark-Russ, Sara, Brighenti, Susanna, Norrby-Teglund, Anna, Eriksson, Lars I., Rooyackers, Olav, Aleman, Soo, Strålin, Kristoffer, Ljunggren, Hans-Gustaf, Ginhoux, Florent, Björkström, Niklas K., Henter, Jan-Inge, Svensson, Mattias

“…Dendritic cells (DCs) and monocytes are crucial mediators of innate and adaptive immune responses during viral infection, but misdirected responses by these…”
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Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination by Gao, Yu, Cai, Curtis, Wullimann, David, Niessl, Julia, Rivera-Ballesteros, Olga, Chen, Puran, Lange, Joshua, Cuapio, Angelica, Blennow, Ola, Hansson, Lotta, Mielke, Stephan, Nowak, Piotr, Vesterbacka, Jan, Akber, Mira, Perez-Potti, Andre, Sekine, Takuya, Müller, Thomas R., Boulouis, Caroline, Kammann, Tobias, Parrot, Tiphaine, Muvva, Jagadeeswara Rao, Sobkowiak, Michal, Healy, Katie, Bogdanovic, Gordana, Muschiol, Sandra, Söderdahl, Gunnar, Österborg, Anders, Hellgren, Fredrika, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Loré, Karin, Sällberg Chen, Margaret, Ljungman, Per, Sandberg, Johan K., Smith, C.I. Edvard, Bergman, Peter, Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus

“…Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of…”
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MAIT cell activation and dynamics associated with COVID-19 disease severity by Parrot, Tiphaine, Gorin, Jean-Baptiste, Ponzetta, Andrea, Maleki, Kimia T, Kammann, Tobias, Emgård, Johanna, Perez-Potti, André, Sekine, Takuya, Rivera-Ballesteros, Olga, Gredmark-Russ, Sara, Rooyackers, Olav, Folkesson, Elin, Eriksson, Lars I, Norrby-Teglund, Anna, Ljunggren, Hans-Gustaf, Björkström, Niklas K, Aleman, Soo, Buggert, Marcus, Klingström, Jonas, Strålin, Kristoffer, Sandberg, Johan K

“…Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is…”
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Functional SARS-CoV-2 cross-reactive CD4 + T cells established in early childhood decline with age by Humbert, Marion, Olofsson, Anna, Wullimann, David, Niessl, Julia, Hodcroft, Emma B, Cai, Curtis, Gao, Yu, Sohlberg, Ebba, Dyrdak, Robert, Mikaeloff, Flora, Neogi, Ujjwal, Albert, Jan, Malmberg, Karl-Johan, Lund-Johansen, Fridtjof, Aleman, Soo, Björkhem-Bergman, Linda, Jenmalm, Maria C, Ljunggren, Hans-Gustaf, Buggert, Marcus, Karlsson, Annika C

“…Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes…”
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Elevated CD21low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency by Bergman, Peter, Wullimann, David, Gao, Yu, Wahren Borgström, Emilie, Norlin, Anna-Carin, Lind Enoksson, Sara, Aleman, Soo, Ljunggren, Hans-Gustaf, Buggert, Marcus, Smith, C. I. Edvard

“…Purpose Limited data is available on the effect of COVID-19 vaccination in immunocompromised individuals. Here, we provide the results from vaccinating a…”
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Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination by Blixt, Lisa, Gao, Yu, Wullimann, David, Murén Ingelman-Sundberg, Hanna, Muschiol, Sandra, Healy, Katie, Bogdanovic, Gordana, Pin, Elisa, Nilsson, Peter, Kjellander, Christian, Grifoni, Alba, Sette, Alessandro, Sällberg Chen, Margaret, Ljunggren, Hans-Gustaf, Buggert, Marcus, Hansson, Lotta, Österborg, Anders

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NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals by Cuapio, Angelica, Boulouis, Caroline, Filipovic, Iva, Wullimann, David, Kammann, Tobias, Parrot, Tiphaine, Chen, Puran, Akber, Mira, Gao, Yu, Hammer, Quirin, Strunz, Benedikt, Pérez Potti, André, Rivera Ballesteros, Olga, Lange, Joshua, Muvva, Jagadeeswara Rao, Bergman, Peter, Blennow, Ola, Hansson, Lotta, Mielke, Stephan, Nowak, Piotr, Söderdahl, Gunnar, Österborg, Anders, Smith, C I Edvard, Bogdanovic, Gordana, Muschiol, Sandra, Hellgren, Fredrika, Loré, Karin, Sobkowiak, Michal J, Gabarrini, Giorgio, Healy, Katie, Sällberg Chen, Margaret, Alici, Evren, Björkström, Niklas K, Buggert, Marcus, Ljungman, Per, Sandberg, Johan K, Aleman, Soo, Ljunggren, Hans-Gustaf

“…Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the…”
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The HLA-B –21 M/T dimorphism associates with disease severity in COVID-19 by Strunz, Benedikt, Momayyezi, Pouria, Bilev, Eleni, Muvva, Jagadeeswara Rao, Chen, Puran, Bister, Jonna, Schaffer, Marie, Akber, Mira, Cornillet, Martin, Aleman, Soo, Berglin, Lena, Bergsten, Helena, Brighenti, Susanna, Brownlie, Demi, Buggert, Marcus, Butrym, Marta, Chambers, Benedict J., Cuapio, Angelica, Lozano, Isabel Diaz, Dillner, Lena, Djärv, Therese, Dzidic, Majda, Emgård, Johanna, Eriksson, Lars I., Flodström-Tullberg, Malin, Glans, Hedvig, Gorin, Jean-Baptiste, Grip, Jonathan, Haroun-Izquierdo, Alvaro, Henriksson, Elisabeth, Hertwig, Laura, Kalsum, Sadaf, Kammann, Tobias, Klingström, Jonas, Kokkinou, Efthymia, Kvedaraite, Egle, Loreti, Marco Giulio, Lourda, Magdalini, Maleki, Kimia T., Malmberg, Karl-Johan, Marquardt, Nicole, Mårtensson, Johan, Maucourant, Christopher, Michaëlsson, Jakob, Mjösberg, Jenny, Moll, Kirsten, Nauclér, Pontus, Norrby-Teglund, Anna, Palma Medina, Laura M., Parrot, Tiphaine, Perez-Potti, Andre, Persson, Björn P., Radler, Lena, Religa, Dorota, Ringqvist, Emma, Rivera-Ballesteros, Olga, Rooyackers, Olav, Sandberg, Johan K., Sandberg, John Tyler, Sekine, Takuya, Sohlberg, Ebba, Soini, Tea, Sönnerborg, Anders, Strålin, Kristoffer, Svensson, Mattias, Tynell, Janne, Unge, Christian, Varnaite, Renata, von Kries, Andreas, Wullimann, David, Horowitz, Amir, Ljunggren, Hans-Gustaf, Björkström, Niklas K., Strålin, Kristoffer, Hammer, Quirin

“…Abstract Host genetics shape immune responses and influence severity of infectious diseases. The HLA-B –21 M/T dimorphism tunes the functionality of natural…”
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Elevated CD21 low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency by Bergman, Peter, Wullimann, David, Gao, Yu, Wahren Borgström, Emilie, Norlin, Anna-Carin, Lind Enoksson, Sara, Aleman, Soo, Ljunggren, Hans-Gustaf, Buggert, Marcus, Smith, C I Edvard

“…Limited data is available on the effect of COVID-19 vaccination in immunocompromised individuals. Here, we provide the results from vaccinating a single-center…”
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The Karolinska KI/K COVID‐19 immune atlas: An open resource for immunological research and educational purposes by Ljunggren, Hans‐Gustaf, Heggernes Ask, Eivind, Cornillet, Martin, Strunz, Benedikt, Chen, Puran, Rao Muvva, Jagadeeswara, Akber, Mira, Buggert, Marcus, Chambers, Benedict J., Cuapio Gomez, Angelica, Filipovic, Iva, Flodström‐Tullberg, Malin, Garcia, Marina, Gredmark‐Russ, Sara, Hertwig, Laura, Kvedaraite, Egle, Lourda, Magda, Mjösberg, Jenny, Norrby‐Teglund, Anna, Palma Medina, Laura M., Parrot, Tiphaine, Perez‐Potti, André, Ponzetta, Andrea, Ringqvist, Emma, Rivera‐Ballesteros, Olga, Rooyackers, Olav, Sandberg, Johan K., Sandberg, John Tyler, Svensson, Mattias, Varnaite, Renata, Wullimann, David, Eriksson, Lars I., Malmberg, Karl‐Johan, Strålin, Kristoffer, Björkström, Niklas K., Aleman, S., Berglin, L., Bergsten, H., Björkström, N.K., Brighenti, S., Brownlie, D., Buggert, M., Butrym, M., Chambers, B.J., Chen, P., Cornillet, M., Lozano, I. Diaz, Dillner, L., Djärv, T., Dzidic, M., Eriksson, L.I., Flodström‐Tullberg, M., Gorin, J.B., Gredmark‐Russ, S., Grip, J., Hammer, Q., Haroun‐Izquierdo, A., Henriksson, E., Hertwig, L., Kalsum, S., Kammann, T., Klingström, J., Kokkinou, E., Kvedaraite, E., Ljunggren, H.G., Marquardt, N., Lourda, M., Maucourant, C., Maleki, K.T., Malmberg, K.J., Michaelsson, J., Mjösberg, J., Moll, K., Muvva, J.R., Mårtensson, J., Nauclér, P., Norrby‐Teglund, A., Medina, L.M. Palma, Parrot, T., Perez‐Potti, A., Persson, B.P., Radler, L., Religa, D., Ringqvist, E., Rivera‐Ballesteros, O., Rooyackers, O., Sandberg, J.K., Sandberg, J.T., Sekine, T., Soini, T., Sohlberg, E., Strunz, B., Strålin, K., Svensson, M., Sönnerborg, A., Tynell, J., Unge, C., Kries, A., Varnaite, R., Wullimann, D.

“…The Karolinska KI/K COVID‐19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS‐CoV‐2…”
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Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a two-year follow-up of the prospective clinical trial COVAXIDResearch in context by Puran Chen, Peter Bergman, Ola Blennow, Lotta Hansson, Stephan Mielke, Piotr Nowak, Yu Gao, Gunnar Söderdahl, Anders Österborg, C.I.Edvard Smith, Jan Vesterbacka, David Wullimann, Angelica Cuapio, Mira Akber, Gordana Bogdanovic, Sandra Muschiol, Mikael Åberg, Karin Loré, Margaret Sällberg Chen, Per Ljungman, Marcus Buggert, Soo Aleman, Hans-Gustaf Ljunggren

“…Background: Immunocompromised patients with primary and secondary immunodeficiencies have shown impaired responses to SARS-CoV-2 mRNA vaccines, necessitating…”
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Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXIDResearch in context by Puran Chen, Peter Bergman, Ola Blennow, Lotta Hansson, Stephan Mielke, Piotr Nowak, Gunnar Söderdahl, Anders Österborg, C.I. Edvard Smith, Jan Vesterbacka, David Wullimann, Angelica Cuapio, Mira Akber, Gordana Bogdanovic, Sandra Muschiol, Mikael Åberg, Karin Loré, Margaret Sällberg Chen, Marcus Buggert, Per Ljungman, Soo Aleman, Hans-Gustaf Ljunggren

“…Background: Immunocompromised patients have varying responses to SARS-CoV-2 mRNA vaccination. However, there is limited information available from prospective…”
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Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a two-year follow-up of the prospective clinical trial COVAXID by Chen, Puran, Bergman, Peter, Blennow, Ola, Hansson, Lotta, Mielke, Stephan, Nowak, Piotr, Gao, Yu, Söderdahl, Gunnar, Österborg, Anders, Smith, C.I.Edvard, Vesterbacka, Jan, Wullimann, David, Cuapio, Angelica, Akber, Mira, Bogdanovic, Gordana, Muschiol, Sandra, Åberg, Mikael, Loré, Karin, Chen, Margaret Sällberg, Ljungman, Per, Buggert, Marcus, Aleman, Soo, Ljunggren, Hans-Gustaf

“…Immunocompromised patients with primary and secondary immunodeficiencies have shown impaired responses to SARS-CoV-2 mRNA vaccines, necessitating…”
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Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID by Chen, Puran, Bergman, Peter, Blennow, Ola, Hansson, Lotta, Mielke, Stephan, Nowak, Piotr, Söderdahl, Gunnar, Österborg, Anders, Smith, C.I. Edvard, Vesterbacka, Jan, Wullimann, David, Cuapio, Angelica, Akber, Mira, Bogdanovic, Gordana, Muschiol, Sandra, Åberg, Mikael, Loré, Karin, Sällberg Chen, Margaret, Buggert, Marcus, Ljungman, Per, Aleman, Soo, Ljunggren, Hans-Gustaf

“…Immunocompromised patients have varying responses to SARS-CoV-2 mRNA vaccination. However, there is limited information available from prospective clinical…”
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Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia by Andersson, Maria, Wu, Jinghua, Wullimann, David, Gao, Yu, Aberg, Mikael, Muschiol, Sandra, Healy, Katie, Naud, Sabrina, Bogdanovic, Gordana, Palma, Marzia, Mellstedt, Hakan, Chen, Puran, Ljunggren, Hans-Gustaf, Hansson, Lotta, Sallberg Chen, Margaret, Buggert, Marcus, Ingelman-Sundberg, Hanna M., Osterborg, Anders

“…Background: Patients with chronic lymphocytic leukemia (CLL) are vulnerable to coronavirus disease 2019 (COVID-19) and are at risk of inferior response to…”
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