Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections

Novel antimicrobial strategies to treat multi‐drug resistant Staphylococcus aureus infections

Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and currently represents one of the most significant threats to global health. Staphylococcus aureus remains a formidable human pathogen with high mortality rates associated with severe systemic infections. S. aure...

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Bibliographic Details
Published in:Microbial biotechnology Vol. 16; no. 7; pp. 1456 - 1474
Main Authors: Douglas, Edward J. A., Wulandari, Sri W., Lovell, Scott D., Laabei, Maisem
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-07-2023
John Wiley and Sons Inc
Wiley
Subjects:
Acids
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Biosynthesis
Cell division
Clinical trials
Drug resistance
Enzymes
Global health
Health services
Hospital costs
Humans
Infectious diseases
Methicillin-Resistant Staphylococcus aureus
Mini Review
Mini Reviews
Multidrug resistance
Pathogens
Polymerization
Proteins
Public health
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus
Staphylococcus aureus
Staphylococcus infections
Virulence
Virulence factors
United States > US
Europe
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Summary:Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and currently represents one of the most significant threats to global health. Staphylococcus aureus remains a formidable human pathogen with high mortality rates associated with severe systemic infections. S. aureus has become notorious as a multidrug resistant bacterium, which when combined with its extensive arsenal of virulence factors that exacerbate disease, culminates in an incredibly challenging pathogen to treat clinically. Compounding this major health issue is the lack of antibiotic discovery and development, with only two new classes of antibiotics approved for clinical use in the last 20 years. Combined efforts from the scientific community have reacted to the threat of dwindling treatment options to combat S. aureus disease in several innovative and exciting developments. This review describes current and future antimicrobial strategies aimed at treating staphylococcal colonization and/or disease, examining therapies that show significant promise at the preclinical development stage to approaches that are currently being investigated in clinical trials. Summary of novel strategies currently being developed to treat multi‐drug resistant Staphylococcus aureus infections.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1751-7915
1751-7915
DOI:10.1111/1751-7915.14268