Search Results - "Wu Zuze"

Safety and Efficacy of Adenovirus Carrying Hepatocyte Growth Factor Gene by Percutaneous Endocardial Injection for Treating Post-infarct Heart Failure: A Phase IIa Clinical Trial by Meng, Haoyu, Chen, Bo, Tao, Zhengxian, Xu, Zhihui, Wang, Liansheng, Weizhu, Ju, Hong, Yongyong, Liu, Xiang, Wang, Hua, Wang, Lisheng, Wu, Zuze, Yang, Zhijian

“…Our previous phase I clinical trial has confirmed the safety of Adenovirus carrying Hepatocyte Growth Factor gene (Ad-HGF) by intracoronary administration for…”
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Catheter-based intramyocardial delivery (NavX) of adenovirus achieves safe and accurate gene transfer in pigs by Chen, Bo, Tao, Zhengxian, Zhao, Yingming, Chen, Hongwu, Yong, Yonghong, Liu, Xiang, Wang, Hua, Wu, Zuze, Yang, Zhijian, Yuan, Li

“…Hepatocyte growth factor (HGF) is one of the major angiogenic factors being studied for the treatment of ischemic heart diseases. Our previous study…”
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Cardiac-specific expression of the hepatocyte growth factor (HGF) under the control of a TnIc promoter confers a heart protective effect after myocardial infarction (MI) by Xu, Zhihui, Tao, Zhengxian, Xu, Zhuowen, Yang, Yuefeng, Wang, Hua, Wang, Lisheng, Wu, Zuze, Tan, Qi, Zhou, Ningtian, Zhang, Ming, Chen, Pengsheng, Yang, Zhijian

“…Uncontrolled therapeutic gene expression and neovascularization in non-specific tissues has lowered the safety of gene therapy. The aim of the study was to…”
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Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats by Chen, Xing, Chen, Zhi, Wang, Hanbin, Xiong, Xishan, Liu, Xiaoling, Hu, Chunsheng, Han, Yuan, Lu, Yuxin, Wu, Zuze, Zhang, Qinglin

“…The clinical application of gentamicin has been limited by its nephrotoxicity, which is characterized by kidney injury, interstitial fibrosis and progressive…”
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A continuous cell alkaline lysis, neutralization, and clarification combination process for production of plasmid pUDK-HGF by Chunsheng, Hu, Qinglin, Zhang, Yuxin, Lu, Xiaochen, Cheng, Yanliang, Wang, Tong, Zhang, Zuze, Wu

“…Plasmid DNA for biopharmaceutical applications is produced easily in Escherichia coli bacteria. The cell lysis is the most crucial step for purification of…”
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Production of plasmid DNA encoding human hepatocyte growth factor for gene therapy by Zhang, Qinglin, Bi, Jianjing, Xiao, Fengjun, Duan, Haifeng, Wu, Bing, Wu, Zuze

“…pUDK‐HGF, recombinant plasmid DNA encoding human HGF (hepatocyte growth factor), is a potential agent for gene therapy of ischaemic disease. Production of…”
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Nonviral vector plasmid DNA encoding human proenkephalin gene attenuates inflammatory and neuropathic pain-related behaviors in mice by Hu, Chunsheng, Cai, Zhenzhen, Lu, Yuxin, Cheng, Xiaochen, Guo, Qi, Wu, Zuze, Zhang, Qinglin

“…•Peripheral or spinal delivery of pVAX1-PENK alleviates CFA-induced pain for an extended period.•Peripheral or spinal delivery of pVAX1-PENK attenuates…”
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Gene therapy for neuropathic pain induced by spared nerve injury with naked plasmid encoding hepatocyte growth factor by Hu, Chunsheng, Lu, Yuxin, Cheng, Xiaochen, Cui, Yufang, Wu, Zuze, Zhang, Qinglin

“…Background Neuropathic pain (NP) is a refractory disease in the clinic with a tremendous impact on the quality of life of patients. Gene therapy is a potential…”
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pUDK-HGF Gene Therapy to Relieve CLI Rest Pain and Ulcer: A Phase II, Double-Blind, Randomized Placebo-Controlled Trial by Gu, Yongquan, Cui, Shijun, Liu, Changjian, Zhao, Jichun, Li, Ming, Li, Yiqing, Yang, Xinglong, Lv, Bonan, Li, Mingzhang, Zhao, Wenguang, Guo, Wei, Huang, Jianhua, Huang, Wen, Qiu, Zhenming, Zhao, Jun, Yin, Ping, Qin, Tingting, Zhu, Dan, Sun, Wenjie, Ren, Keyun, Lu, Yuxin, Cheng, Xiaochen, Du, Li, Xiao, Fengjun, Zhang, Qinglin, Wu, Zuze

“…This phase II clinical trial investigated the efficacy and safety of intramuscular injection of plasmid pUDK-HGF, which encodes the human hepatocyte growth…”
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Gene therapy for pathological scar with hepatocyte growth factor mediated by recombinant adenovirus vector by Ha, Xiaoqin, Yuan, Bin, Li, Yuanmin, Lao, Miaofen, Wu, Zuze

“…A complementary DNA (cDNA) encoding human hepatocyte growth factor was introduced into a replication-defective type 5 adenovirus (lacking E1, E3 domains)…”
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Local intramuscular injection of a plasmid encoding human proenkepahlin attenuates incision pain in rats by Hu, Chunsheng, Cai, Zhenzhen, Lu, Yuxin, Cheng, Xiaochen, Wu, Zuze, Zhang, Qinglin

“…•Surgical incision resulted in mechanical allodynia and thermal hyperalgesia in rats.•Local intramuscular injection of pVAX1-PENK attenuated nocifensive…”
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Mesenchymal stromal cell-conditioned medium prevents radiation-induced small intestine injury in mice by Gao, Zhimai, Zhang, Qinglin, Han, Yuan, Cheng, Xiaochen, Lu, Yuxin, Fan, Libin, Wu, Zuze

“…Abstract Background aims Effective therapy for radiation-induced intestinal injury is currently unavailable. Mesenchymal stromal cells (MSC) are expected to be…”
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Human hepatopoietin and its relationship with liver regeneration by He, Fuchu, Wu, Zuze

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Human augmenter of liver regeneration: molecular cloning, biological activity and roles in liver regeneration by 杨晓明 谢玲 邱兆华 吴祖泽 贺福初

“…The complete amino acid sequence of human augmenter of liver regeneration (hALR) was reported by deduction from nucleotide sequence of its complementary DNA …”
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Human hepatopoietin augmenter of liver regeneration — A hepatotrophic factor for liver regeneration, and its potential antihepatitis effectin vivo by Yang, Xiaoming, Wang, Aimin, Zhou, Ping, Xie, Ling, Wang, Qingming, Wu, Zuze, He, Fuchu

“…The effect of human hapatopoietin i. e. augmenter of liver regeneration (hALR) was determined on hepatocyte DNA synthesis, and on CCl4-induced hepatitis in…”
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Phenomenon and mechanism of “secondary damage” during repair of DNA damage in irradiated mammalian cells by Luo, Ying, Sun, Zhixian, Wu, Zuze

“…By means of comet assay, a study of kinetics curve of DNA damage repair in irradiated SX-9 cells that came from mouse breast cancer proceeded. It was found…”
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Catheter-Based Intramyocardial Delivery by Chen, Bo, Tao, Zhengxian, Zhao, Yingming, Chen, Hongwu, Yong, Yonghong, Liu, Xiang, Wang, Hua, Wu, Zuze, Yang, Zhijian, Yuan, Li

“…Background Hepatocyte growth factor (HGF) is one of the major angiogenic factors being studied for the treatment of ischemic heart diseases. Our previous study…”
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Antisense oligodeoxynucleotide targeting HER2 mRNA sensitized docetaxel in breast cancer treatment by Sun, Junzhong, Xu, Yin, Song, Santai, Wu, Zuze, Duan, Haifeng

“…Human epidermal growth factor receptor 2 (HER2) is one of the oncogenes closely associated with the development and prognosis of breast carcinoma…”
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Gram-scale production of plasmid pUDK-HGF with current good manufacturing practices for gene therapy of critical limb ischemia by Hu, ChunSheng, Cheng, XiaoChen, Lu, YuXin, Wu, ZuZe, Zhang, QingLin

“…The demand of a plasmid encoding human hepatocyte growth factor gene (pUDK-HGF) in large quantities at high purity and concentration has increased for gene…”
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Gene therapy for rat renal anemia with implantation of erythropoietin-transgenic myoblasts by Liu, Y, Wei, H, Wu, Z, He, F

“…To investigate whether an erythropoietin (EPO) gene-based therapy could serve as an alternative to the repeated injection of rhEPO in treatment to renal…”
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