Search Results - "Wu, Warren L."

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids by LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-Kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales

“…Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire novel nutrient dependencies to support oncogenic growth. A major genetic…”
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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion by Marzio, Antonio, Kurz, Emma, Sahni, Jennifer M., Di Feo, Giuseppe, Puccini, Joseph, Jiang, Shaowen, Hirsch, Carolina Alcantara, Arbini, Arnaldo A., Wu, Warren L., Pass, Harvey I., Bar-Sagi, Dafna, Papagiannakopoulos, Thales, Pagano, Michele

“…Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to immunotherapy. Here, we show that KEAP1 targets EMSY for…”
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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer by Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales

“…During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis,…”
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KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance by Zavitsanou, Anastasia-Maria, Pillai, Ray, Hao, Yuan, Wu, Warren L., Bartnicki, Eric, Karakousi, Triantafyllia, Rajalingam, Sahith, Herrera, Alberto, Karatza, Angeliki, Rashidfarrokhi, Ali, Solis, Sabrina, Ciampricotti, Metamia, Yeaton, Anna H., Ivanova, Ellie, Wohlhieter, Corrin A., Buus, Terkild B., Hayashi, Makiko, Karadal-Ferrena, Burcu, Pass, Harvey I., Poirier, John T., Rudin, Charles M., Wong, Kwok-Kin, Moreira, Andre L., Khanna, Kamal M., Tsirigos, Aristotelis, Papagiannakopoulos, Thales, Koralov, Sergei B.

“…Lung cancer treatment has benefited greatly through advancements in immunotherapies. However, immunotherapy often fails in patients with specific mutations…”
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Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition by Ding, Hongyu, Chen, Zihong, Wu, Katherine, Huang, Shih Ming, Wu, Warren L, LeBoeuf, Sarah E, Pillai, Ray G, Rabinowitz, Joshua D, Papagiannakopoulos, Thales

“…The pathway promotes metabolic rewiring to support redox homeostasis. Activation of NRF2 occurs in many cancers, often due to mutations, and is associated with…”
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The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension by Wu, Warren L., Papagiannakopoulos, Thales

“…Takahashi et al. (2020) conduct a focused CRISPR/Cas9 screen against NRF2 target and other redox regulatory genes in both 2D- and 3D-culture systems,…”
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The Pleiotropic Role of the KEAP1 NRF2 Pathway in Cancer by Wu, Warren L, Papagiannakopoulos, Thales

“…The unregulated proliferative capacity of many tumors is dependent on dysfunctional nutrient utilization and ROS (reactive oxygen species) signaling to sustain…”
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Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer by Pillai, Ray, LeBoeuf, Sarah E, Hao, Yuan, New, Connie, Blum, Jenna L E, Rashidfarrokhi, Ali, Huang, Shih Ming, Bahamon, Christian, Wu, Warren L, Karadal-Ferrena, Burcu, Herrera, Alberto, Ivanova, Ellie, Cross, Michael, Bossowski, Jozef P, Ding, Hongyu, Hayashi, Makiko, Rajalingam, Sahith, Karakousi, Triantafyllia, Sayin, Volkan I, Khanna, Kamal M, Wong, Kwok-Kin, Wild, Robert, Tsirigos, Aristotelis, Poirier, John T, Rudin, Charles M, Davidson, Shawn M, Koralov, Sergei B, Papagiannakopoulos, Thales

“…Loss-of-function mutations in frequently occur in lung cancer and are associated with poor prognosis and resistance to standard of care treatment, highlighting…”
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Imprinted DNA methylation reconstituted at a non-imprinted locus by Taylor, David H, McLean, Chelsea M, Wu, Warren L, Wang, Alex B, Soloway, Paul D

“…In mammals, tight regulation of cytosine methylation is required for embryonic development and cellular differentiation. The trans-acting DNA…”
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Slug contributes to cancer progression by direct regulation of ERα signaling pathway by LI, YOUQIANG, WU, YANYUAN, ABBATIELLO, THOMAS C, WU, WARREN L, KIM, JU RI, SARKISSYAN, MARIANNA, SARKISSYAN, SUREN, CHUNG, SEYUNG S, ELSHIMALI, YAHYA, VADGAMA, JAYDUTT V

“…Hormone therapy targeting estrogen receptor α (ERα) is the most effective treatment for breast cancer. However, this treatment eventually fails as the tumor…”
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