Search Results - "Wu, Tony J."

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways by Boelens, Mirjam C., Wu, Tony J., Nabet, Barzin Y., Xu, Bihui, Qiu, Yu, Yoon, Taewon, Azzam, Diana J., Twyman-Saint Victor, Christina, Wiemann, Brianne Z., Ishwaran, Hemant, ter Brugge, Petra J., Jonkers, Jos, Slingerland, Joyce, Minn, Andy J.

“…Stromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine…”
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Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer by Nabet, Barzin Y., Qiu, Yu, Shabason, Jacob E., Wu, Tony J., Yoon, Taewon, Kim, Brian C., Benci, Joseph L., DeMichele, Angela M., Tchou, Julia, Marcotrigiano, Joseph, Minn, Andy J.

“…Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses. Although…”
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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade by Benci, Joseph L., Xu, Bihui, Qiu, Yu, Wu, Tony J., Dada, Hannah, Twyman-Saint Victor, Christina, Cucolo, Lisa, Lee, David S.M., Pauken, Kristen E., Huang, Alexander C., Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Feldman, Michael D., Ishwaran, Hemant, Vonderheide, Robert H., Maity, Amit, Wherry, E. John, Minn, Andy J.

“…Therapeutic blocking of the PD1 pathway results in significant tumor responses, but resistance is common. We demonstrate that prolonged interferon signaling…”
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Abstract C65: Identifying mechanisms of macrophage-mediated metastasis and therapy resistance in PDAC by Wu, Tony J., Cast, Oliver, Memon, Danish, Jimenez-Sanchez, Alejandro, Machel, Anne, Kehrloesser, Sebastian, Gill, Michael B., Miller, Martin L.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by desmoplasia, with macrophages as one of the most abundant, multifunctional immune cell populations…”
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Abstract A45: Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways in triple-negative breast cancer by Wu, Tony J., Nabet, Barzin Y., Xu, Bihui, Boelens, Mirjam C., Jonkers, Jos, Minn, Andy J.

“…Breast cancer cells can achieve protection from DNA damage both through cell-autonomous mechanisms and intercellular communication with the tumor…”
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Abstract 1505: Stroma-mediated DNA damage resistance of human breast cancer by Boelens, Mirjam C., Wu, Tony J., Yoon, Taewon, Azzam, Diana, Slingerland, Joyce M., Minn, Andy J.

“…Chemotherapy and radiation are often employed to decrease breast cancer deaths. However, patients with metastatic disease invariably manifest resistance to…”
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