Search Results - "Wu, Ryan T. Y"

Loss of Selenium-Binding Protein 1 Decreases Sensitivity to Clastogens and Intracellular Selenium Content in HeLa Cells by Zhao, Changhui, Zeng, Huawei, Wu, Ryan T Y, Cheng, Wen-Hsing

“…Selenium-binding protein 1 (SBP1) is not a selenoprotein but structurally binds selenium. Loss of SBP1 during carcinogenesis usually predicts poor prognosis…”
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Effect of Dietary Selenium and Cancer Cell Xenograft on Peripheral T and B Lymphocytes in Adult Nude Mice by Cheng, Wen-Hsing, Holmstrom, Alexandra, Li, Xiangdong, Wu, Ryan T. Y., Zeng, Huawei, Xiao, Zhengguo

“…Selenium (Se) is known to regulate tumorigenesis and immunity at the nutritional and supranutritional levels. Because the immune system provides critical…”
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Role for p53 in Selenium-Induced Senescence by Wu, Min, Wu, Ryan T. Y, Wang, Thomas T. Y, Cheng, Wen-Hsing

“…The tumor suppressor p53 and the ataxia-telangiectasia mutated (ATM) kinase play important roles in the senescence response to oncogene activation and DNA…”
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Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice by Holmstrom, Alexandra, Wu, Ryan, T.Y, Zeng, Huawei, Lei, K.Y, Cheng, Wen-Hsing

“…The inhibitory effect of oral methylseleninic acid or methylselenocysteine administration on cancer cell xenograft development in nude mice is well…”
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Analyses of Selenotranscriptomes and Selenium Concentrations in Response to Dietary Selenium Deficiency and Age Reveal Common and Distinct Patterns by Tissue and Sex in Telomere-Dysfunctional Mice by Cao, Lei, Zhang, Li, Zeng, Huawei, Wu, Ryan Ty, Wu, Tung-Lung, Cheng, Wen-Hsing

“…The hierarchies of tissue selenium distribution and selenotranscriptomes are thought to critically affect healthspan and longevity. We determined selenium…”
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Selenoprotein H Suppresses Cellular Senescence through Genome Maintenance and Redox Regulation by Wu, Ryan T.Y., Cao, Lei, Chen, Benjamin P.C., Cheng, Wen-Hsing

“…Oxidative stress and persistent DNA damage response contribute to cellular senescence, a degeneration process critically involving ataxia…”
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Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons by Yao, Pamela J, Manor, Uri, Petralia, Ronald S, Brose, Rebecca D, Wu, Ryan T Y, Ott, Carolyn, Wang, Ya-Xian, Charnoff, Ari, Lippincott-Schwartz, Jennifer, Mattson, Mark P

“…Mitochondria are essential organelles whose biogenesis, structure, and function are regulated by many signaling pathways. We present evidence that, in…”
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Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death by Cheng, Wen-Hsing, Wu, Ryan T.Y., Wu, Min, Rocourt, Caroline R.B., Carrillo, Jose A., Song, Jiuzhou, Bohr, Christina T., Tzeng, Tiffany J.

“…► We investigate novel strategy improving selenium effect on cancer cytotoxicity. ► Werner syndrome protein facilitates the repair of selenium-induced DNA…”
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New insight into telomere maintenance by Wu, Ryan T Y, Cheng, Wen-Hsing

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A role for Selenoprotein H in genome stability maintenance against oxidative stress by Wu, Ryan TY, Cheng, Wen-Hsing

“…Abstract only Selenoprotein H (SelH) is a nuclear selenoprotein known to play dual roles in redox maintenance and transcriptional activation in the response to…”
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Targeting DNA repair protein as an approach for sensitizing cancer cells to methylseleninic acid by Tzeng, Tiffany J, Wu, Ryan TY, Rocourt, Caroline RB, Cheng, Wen-Hsing

“…Abstract only DNA‐dependent protein kinase (DNA‐PK cs ) is part of the DNA‐PK complex that senses and repairs DNA double strand breaks by the nonhomologous…”
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