Search Results - "Wu, Ronghai"

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model by Cen, Xufeng, Chen, Yanying, Xu, Xiaoyan, Wu, Ronghai, He, Fusheng, Zhao, Qingwei, Sun, Qiming, Yi, Cong, Wu, Jie, Najafov, Ayaz, Xia, Hongguang

“…There is increasing evidence that inducing neuronal mitophagy can be used as a therapeutic intervention for Alzheimer’s disease. Here, we screen a library of…”
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CasHRA (Cas9-facilitated Homologous Recombination Assembly) method of constructing megabase-sized DNA by Zhou, Jianting, Wu, Ronghai, Xue, Xiaoli, Qin, Zhongjun

“…Current DNA assembly methods for preparing highly purified linear subassemblies require complex and time-consuming in vitro manipulations that hinder their…”
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ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation by Wu, Youqian, Zhang, Chao, Liu, Xiaolan, He, Zhengfu, Shan, Bing, Zeng, Qingxin, Zhao, Qingwei, Zhu, Huaying, Liao, Hongwei, Cen, Xufeng, Xu, Xiaoyan, Zhang, Mengmeng, Hou, Tingjun, Wang, Zhe, Yan, Huanhuan, Yang, Shuying, Sun, Yaqin, Chen, Yanying, Wu, Ronghai, Xie, Tingxue, Chen, Wei, Najafov, Ayaz, Ying, Songmin, Xia, Hongguang

“…Cancer expression of PD-L1 suppresses anti-tumor immunity. PD-L1 has emerged as a remarkable therapeutic target. However, the regulation of PD-L1 degradation…”
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Pinning of dislocations in disordered alloys: effects of dislocation orientation by Zaiser, Michael, Wu, Ronghai

“…The current interest in compositionally complex alloys including so called high entropy alloys has caused renewed interest in the general problem of solute…”
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Cell structure formation in a two-dimensional density-based dislocation dynamics model by Wu, Ronghai, Zaiser, Michael

“…Cellular patterns formed by self-organization of dislocations are a most conspicuous feature of dislocation microstructure evolution during plastic…”
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Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation by Xu, Xiaoyan, Xie, Tingxue, Zhou, Mengxin, Sun, Yaqin, Wang, Fengqi, Tian, Yanan, Chen, Ziyan, Xie, Yanqi, Wu, Ronghai, Cen, Xufeng, Zhou, Jichun, Hou, Tingjun, Zhang, Lei, Huang, Chaoyang, Zhao, Qingwei, Wang, Dongrui, Xia, Hongguang

“…Immune checkpoint inhibition targeting the PD-1/PD-L1 pathway has become a powerful clinical strategy for treating cancer, but its efficacy is complicated by…”
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ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade by Liu, Xiaolan, Cen, Xufeng, Wu, Ronghai, Chen, Ziyan, Xie, Yanqi, Wang, Fengqi, Shan, Bing, Zeng, Linghui, Zhou, Jichun, Xie, Bojian, Cai, Yangjun, Huang, Jinyan, Liang, Yingjiqiong, Wu, Youqian, Zhang, Chao, Wang, Dongrui, Xia, Hongguang

“…Despite advances in cancer treatment, immune checkpoint blockade (ICB) only achieves complete response in some patients, illustrating the need to identify…”
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Characterization and Analysis of Strain Heterogeneity at Grain-Scale of Titanium Alloy with Tri-Modal Microstructure during Tensile Deformation by Gao, Pengfei, Li, Yanxi, Wu, Ronghai, Lei, Zhenni, Cai, Yang, Zhan, Mei

“…Grain-scale strain heterogeneity characteristics play a critical role in the ductile damage behavior and mechanical properties of two-phase titanium alloys. In…”
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Phase-field, dislocation based plasticity and damage coupled model: Modelling and application to single crystal superalloys by Wu, Ronghai, Zhang, Yufan

“…In the present work, we propose a novel model coupling phase-field, dislocation density based plasticity and damage. The dislocation density governing…”
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Thermodynamic considerations on a class of dislocation-based constitutive models by Wu, Ronghai, Zaiser, Michael

“…Dislocations are the main carriers of plastic deformation in crystalline materials. Physically based constitutive equations of crystal plasticity typically…”
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Thermodynamic calculation of glass formation for Co-ETM alloys based on Miedema's model by HONGYING LI, XIAOCHAO LU, YANG LIU, RONGHAI WU, HAO YIN, MAOSHENG HAN, GUANG CHEN

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Insights from a minimal model of dislocation-assisted rafting in single crystal Nickel-based superalloys by Wu, Ronghai, Sandfeld, Stefan

“…Nickel-based superalloys play a major role in many technologically relevant high temperature applications. Understanding and predicting the evolution of the…”
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A dislocation dynamics-assisted phase field model for Nickel-based superalloys: The role of initial dislocation density and external stress during creep by Wu, Ronghai, Sandfeld, Stefan

“…The effect of initial dislocation density and external stress on primary creep of Nickel-based superalloys are studied by a combined continuum dislocation…”
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Cyclic-loading microstructure-property relations from a mesoscale perspective: An example of single crystal Nickel-based superalloys by Wu, Ronghai, Zaiser, Michael

“…Past models of stress-strain response under cyclic loading mainly rely on macroscopic equations which consider microstructure evolution indirectly or simply…”
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Effect of initial γ/γ′ microstructure on creep of single crystal nickel-based superalloys: A phase-field simulation incorporating dislocation dynamics by Wu, Ronghai, Yue, Zhufeng, Wang, Meng

“…The initial γ/γ′ microstructure (e.g. γ′ shape, size, volume fraction) may dramatically affect creep behaviour of single crystal Nickel-based superalloys…”
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A continuum approach to combined γ/γ′ evolution and dislocation plasticity in Nickel-based superalloys by Wu, Ronghai, Zaiser, Michael, Sandfeld, Stefan

“…In single crystal Nickel-based superalloys subject to creep loading, the γ/γ′ phase microstructure co-evolves with the system of dislocations under load…”
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Study on hot deformation behavior and intrinsic workability of 6063 aluminum alloys using 3D processing map by Wu, Ronghai, Liu, Yang, Geng, Cong, Lin, Qiquan, Xiao, Yifeng, Xu, Junrui, Kang, Wei

“…Hot deformation in 6063 aluminum alloys was investigated by hot compression testing over the temperature range of 573–723 K with strain rates of 0.01–10 s−1…”
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Effect of Re on mechanical properties of single crystal Ni-based superalloys: Insights from first-principle and molecular dynamics by Wu, Ronghai, Yin, Qian, Wang, Jiapo, Mao, Qianzhu, Zhang, Xu, Wen, Zhixun

“…Re is one of the newly added key elements of single crystal Ni-based superalloys for advanced aero-engine turbine blades. The mechanisms that how Re influences…”
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Composition, heat treatment, microstructure and loading condition based machine learning prediction of creep life of superalloys by Wu, Ronghai, Zeng, Lei, Fan, Jiangkun, Peng, Zichao, Zhao, Yunsong

“…Creep life is a key property of superalloys that are typically used in advanced engine turbine. The creep life of superalloys is mainly determined by factors…”
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Investigation of the relation between bainitic-ferritic microstructures and coincidence-site lattice boundaries by electron backscatter diffraction by Wu, Ronghai, Zhang, Yufan, Sun, Fengwei

“…•Systematic characterization of bainitic-ferritic microstructures and boundaries.•A featured relation between microstructures and boundary misorientations.•A…”
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