Search Results - "Wu, Qi‐Nian"

Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming by Liu, Jia, Liu, Ze-Xian, Wu, Qi-Nian, Lu, Yun-Xin, Wong, Chau-Wei, Miao, Lei, Wang, Yun, Wang, Zixian, Jin, Ying, He, Ming-Ming, Ren, Chao, Wang, De-Shen, Chen, Dong-Liang, Pu, Heng-Ying, Feng, Lin, Li, Bo, Xie, Dan, Zeng, Mu-Sheng, Huang, Peng, Lin, Aifu, Lin, Dongxin, Xu, Rui-Hua, Ju, Huai-Qiang

“…Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying…”
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LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer by Wang, Yun, Lu, Jia-Huan, Wu, Qi-Nian, Jin, Ying, Wang, De-Shen, Chen, Yan-Xing, Liu, Jia, Luo, Xiao-Jing, Meng, Qi, Pu, Heng-Ying, Wang, Ying-Nan, Hu, Pei-Shan, Liu, Ze-Xian, Zeng, Zhao-Lei, Zhao, Qi, Deng, Rong, Zhu, Xiao-Feng, Ju, Huai-Qiang, Xu, Rui-Hua

“…Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that…”
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CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis by Wang, Ying-nan, Zeng, Zhao-lei, Lu, Jiahuan, Wang, Yun, Liu, Ze-xian, He, Ming-ming, Zhao, Qi, Wang, Zi-xian, Li, Ting, Lu, Yun-xin, Wu, Qi-nian, Yu, Kai, Wang, Feng, Pu, Heng-Ying, Li, Bo, Jia, Wei-hua, shi, Ming, Xie, Dan, Kang, Tie-bang, Huang, Peng, Ju, Huai-qiang, Xu, Rui-hua

“…Anoikis is a critical obstacle to cancer metastasis. Colorectal cancer (CRC) exhibits a high rate of metastasis, leading to death, and the mechanisms involved…”
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ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis by Lu, Yun-Xin, Ju, Huai-Qiang, Liu, Ze-Xian, Chen, Dong-Liang, Wang, Yun, Zhao, Qi, Wu, Qi-Nian, Zeng, Zhao-Lei, Qiu, Hai-Bo, Hu, Pei-Shan, Wang, Zhi-Qiang, Zhang, Dong-Sheng, Wang, Feng, Xu, Rui-Hua

“…Genomic alterations of tumor suppressorsoften encompass collateral protein-coding genes that create therapeutic vulnerability to further inhibition of their…”
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A circRNA signature predicts postoperative recurrence in stage II/III colon cancer by Ju, Huai‐Qiang, Zhao, Qi, Wang, Feng, Lan, Ping, Wang, Zixian, Zuo, Zhi‐Xiang, Wu, Qi‐Nian, Fan, Xin‐Juan, Mo, Hai‐Yu, Chen, Li, Li, Ting, Ren, Chao, Wan, Xiang‐Bo, Chen, Gong, Li, Yu‐Hong, Jia, Wei‐Hua, Xu, Rui‐Hua

“…Accurate risk stratification for patients with stage II/III colon cancer is pivotal for postoperative treatment decisions. Here, we aimed to identify and…”
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Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis by Lin, Jin-Fei, Hu, Pei-Shan, Wang, Yi-Yu, Tan, Yue-Tao, Yu, Kai, Liao, Kun, Wu, Qi-Nian, Li, Ting, Meng, Qi, Lin, Jun-Zhong, Liu, Ze-Xian, Pu, Heng-Ying, Ju, Huai-Qiang, Xu, Rui-Hua, Qiu, Miao-Zhen

“…Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity…”
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Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications by Ju, Huai-Qiang, Lu, Yun-Xin, Chen, Dong-Liang, Zuo, Zhi-Xiang, Liu, Ze-Xian, Wu, Qi-Nian, Mo, Hai-Yu, Wang, Zi-Xian, Wang, De-Shen, Pu, Heng-Ying, Zeng, Zhao-Lei, Li, Bo, Xie, Dan, Huang, Peng, Hung, Mien-Chie, Chiao, Paul J, Xu, Rui-Hua

“…Abstract Background Overcoming oxidative stress is a critical step for tumor progression; however, the underlying mechanisms in colorectal cancer (CRC) remain…”
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METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway by Yang, Dong-Dong, Chen, Zhan-Hong, Yu, Kai, Lu, Jia-Huan, Wu, Qi-Nian, Wang, Yun, Ju, Huai-Qiang, Xu, Rui-Hua, Liu, Ze-Xian, Zeng, Zhao-Lei

“…Methyltransferase-like 3 (METTL3), a major component of the N6-methyladenosine (m6A) methyltransferase complex, has been suggested to function as an oncogene…”
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Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance by Wu, Qi-Nian, Liao, Yi-Fu, Lu, Yun-Xin, Wang, Yun, Lu, Jia-Huan, Zeng, Zhao-Lei, Huang, Qi-Tao, Sheng, Hui, Yun, Jing-Ping, Xie, Dan, Ju, Huai-Qiang, Xu, Rui-Hua

“…Gastric cancer (GC) is the second cause of cancer-related death. Cisplatin (CDDP) is widely used as the standard GC treatment, but relapse and metastasis are…”
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miR-125b Is Methylated and Functions as a Tumor Suppressor by Regulating the ETS1 Proto-oncogene in Human Invasive Breast Cancer by YAN ZHANG, YAN, Li-Xu, HUANG, Wen-Lin, ZENG, Yi-Xin, SHAO, Jian-Yong, WU, Qi-Nian, DU, Zi-Ming, JING CHEN, LIAO, Ding-Zhun, HUANG, Ma-Yan, HOU, Jing-Hui, WU, Qiu-Liang, ZENG, Mu-Sheng

“…The microRNA miR-125b is dysregulated in various human cancers but its underlying mechanisms of action are poorly understood. Here, we report that miR-125b is…”
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Deciphering clonal dynamics and metastatic routines in a rare patient of synchronous triple-primary tumors and multiple metastases with MPTevol by Chen, Qingjian, Wu, Qi-Nian, Rong, Yu-Ming, Wang, Shixiang, Zuo, Zhixiang, Bai, Long, Zhang, Bei, Yuan, Shuqiang, Zhao, Qi

“…Abstract Multiple primary tumor (MPT) is a special and rare cancer type, defined as more than two primary tumors presenting at the diagnosis in a single…”
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The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer by Li, Jia-Jun, Wang, Jin-Hong, Tian, Tian, Liu, Jia, Zheng, Yong-Qiang, Mo, Hai-Yu, Sheng, Hui, Chen, Yan-Xing, Wu, Qi-Nian, Han, Yi, Liao, Kun, Pan, Yi-Qian, Zeng, Zhao-Lei, Liu, Ze-Xian, Yang, Wei, Xu, Rui-Hua, Ju, Huai-Qiang

“…Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here,…”
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Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells by Miao, Lei, Qi, Jingjing, Zhao, Qi, Wu, Qi-Nian, Wei, Da-Liang, Wei, Xiao-Li, Liu, Jia, Chen, Jun, Zeng, Zhao-Lei, Ju, Huai-Qiang, Luo, Hui-Yan, Xu, Rui-Hua

“…STING is a critical player in the innate and adaptive immune system, sensing cytosolic DNA to activate the expression of interferon genes and regulate T…”
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Targeting Wnt/β-Catenin Signaling by TET1/FOXO4 Inhibits Metastatic Spreading and Self-Renewal of Cancer Stem Cells in Gastric Cancer by Qi, Jingjing, Cui, Di, Wu, Qi-Nian, Zhao, Qi, Chen, Zhan-Hong, Li, Lianjie, Birchmeier, Walter, Yu, Yong, Tao, Ran

“…Metastasis is the main cause of death for patients suffering gastric cancer. Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) are critical…”
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LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription by Luo, Xiao-Jing, He, Ming-Ming, Liu, Jia, Zheng, Jia-Bo, Wu, Qi-Nian, Chen, Yan-Xing, Meng, Qi, Luo, Kong-Jia, Chen, Dong-Liang, Xu, Rui-Hua, Zeng, Zhao-Lei, Liu, Ze-Xian, Luo, Hui-Yan

“…Esophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding…”
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Hepatitis B virus infection is associated with younger median age at diagnosis and death in cancers by Wei, Xiao‐li, Luo, Hui‐yan, Li, Chao‐feng, Jin, Ying, Zeng, Zhao‐lei, Ju, Huai‐qiang, Wu, Qi‐nian, Wang, Yun, Mao, Min‐jie, Liu, Wan‐li, Jia, Wei‐hua, Zhang, Hui‐zhong, Li, Yu‐hong, Wang, Feng, Xu, Rui‐hua

“…Several non‐hepatocellular cancers were linked with hepatitis B virus (HBV) infection. This study was aimed to quantify the potential associations between HBV…”
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Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer by Chen, Zhan-Hong, Qi, Jing-Jing, Wu, Qi-Nian, Lu, Jia-Huan, Liu, Ze-Xian, Wang, Yun, Hu, Pei-Shan, Li, Ting, Lin, Jin-Fei, Wu, Xiang-Yuan, Miao, Lei, Zeng, Zhao-Lei, Xie, Dan, Ju, Huai-Qiang, Xu, Rui-Hua, Wang, Feng

“…Deregulation of protein translation control is a hallmark of cancers. Eukaryotic initiation factor 4A2 (EIF4A2) is required for mRNA binding to ribosome and…”
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Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma by Liu, Jia, Zhou, Wei‐Yi, Luo, Xiao‐Jing, Chen, Yan‐Xing, Wong, Chau‐Wei, Liu, Ze‐Xian, Bo Zheng, Jia‐, Yu Mo, Hai‐, Chen, Jun‐Quan, Li, Jia‐Jun, Zhong, Ming, Xu, Yu‐Hong, Zhang, Qi‐Hua, Pu, Heng‐Ying, Wu, Qi‐Nian, Jin, Ying, Wang, Zi‐Xian, Xu, Rui‐Hua, Luo, Hui‐Yan

“…Abstract Background Predictive biomarkers for oesophageal squamous cell carcinoma (ESCC) immunotherapy are lacking, and immunotherapy resistance remains to be…”
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The lncRNA XIST/miR‐125b‐2‐3p axis modulates cell proliferation and chemotherapeutic sensitivity via targeting Wee1 in colorectal cancer by Zeng, Zhao‐lei, Lu, Jia‐huan, Wang, Yun, Sheng, Hui, Wang, Ying‐nan, Chen, Zhan‐hong, Wu, Qi‐nian, Zheng, Jia‐Bo, Chen, Yan‐xing, Yang, Dong‐dong, Yu, Kai, Mo, Hai‐yu, Hu, Jia‐jia, Hu, Pei‐shan, Liu, Ze‐xian, Ju, Huai‐qiang, Xu, Rui‐Hua

“…Background Numerous reports on microRNAs have illustrated their role in tumor growth and metastasis. Recently, a new prognostic factor, miR‐125b‐2‐3p, has been…”
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Precise microdissection of gastric mixed adeno-neuroendocrine carcinoma dissects its genomic landscape and evolutionary clonal origins by Qiu, Miao-Zhen, Chen, Qingjian, Zheng, Dan-Yang, Zhao, Qi, Wu, Qi-Nian, Zhou, Zhi-Wei, Yang, Li-Qiong, Luo, Qiu-Yun, Sun, Yu-Ting, Lai, Ming-Yu, Yuan, Sha-Sha, Wang, Feng-Hua, Luo, Hui-Yan, Wang, Feng, Li, Yu-Hong, Zhang, Hui-Zhong, Xu, Rui-Hua

“…Gastric mixed adenoneuroendocrine carcinoma (MANEC) is a clinically aggressive and heterogeneous tumor composed of adenocarcinoma (ACA) and neuroendocrine…”
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