Search Results - "Wu, Nicholas C."

A Comprehensive Biophysical Description of Pairwise Epistasis throughout an Entire Protein Domain by Olson, C. Anders, Wu, Nicholas C., Sun, Ren

“…Nonadditivity in fitness effects from two or more mutations, termed epistasis, can result in compensation of deleterious mutations or negation of beneficial…”
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Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies by Yuan, Meng, Liu, Hejun, Wu, Nicholas C., Wilson, Ian A.

“…Immediately from the outset of the COVID-19 pandemic, researchers from diverse biomedical and biological disciplines have united to study the novel pandemic…”
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A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus by Wu, Nicholas C., Wilson, Ian A.

“…Influenza virus evolves rapidly to constantly escape from natural immunity. Most humoral immune responses to influenza virus target the hemagglutinin (HA)…”
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A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV by Yuan, Meng, Wu, Nicholas C, Zhu, Xueyong, Lee, Chang-Chun D, So, Ray T Y, Lv, Huibin, Mok, Chris K P, Wilson, Ian A

“…The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there…”
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Structural basis of a shared antibody response to SARS-CoV-2 by Yuan, Meng, Liu, Hejun, Wu, Nicholas C, Lee, Chang-Chun D, Zhu, Xueyong, Zhao, Fangzhu, Huang, Deli, Yu, Wenli, Hua, Yuanzi, Tien, Henry, Rogers, Thomas F, Landais, Elise, Sok, Devin, Jardine, Joseph G, Burton, Dennis R, Wilson, Ian A

“…Molecular understanding of neutralizing antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could accelerate vaccine design and…”
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A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine by Wu, Nicholas C, Zost, Seth J, Thompson, Andrew J, Oyen, David, Nycholat, Corwin M, McBride, Ryan, Paulson, James C, Hensley, Scott E, Wilson, Ian A

“…The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A…”
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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model by Rogers, Thomas F, Zhao, Fangzhu, Huang, Deli, Beutler, Nathan, Burns, Alison, He, Wan-Ting, Limbo, Oliver, Smith, Chloe, Song, Ge, Woehl, Jordan, Yang, Linlin, Abbott, Robert K, Callaghan, Sean, Garcia, Elijah, Hurtado, Jonathan, Parren, Mara, Peng, Linghang, Ramirez, Sydney, Ricketts, James, Ricciardi, Michael J, Rawlings, Stephen A, Wu, Nicholas C, Yuan, Meng, Smith, Davey M, Nemazee, David, Teijaro, John R, Voss, James E, Wilson, Ian A, Andrabi, Raiees, Briney, Bryan, Landais, Elise, Sok, Devin, Jardine, Joseph G, Burton, Dennis R

“…Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory…”
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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants by Yuan, Meng, Huang, Deli, Lee, Chang-Chun D, Wu, Nicholas C, Jackson, Abigail M, Zhu, Xueyong, Liu, Hejun, Peng, Linghang, van Gils, Marit J, Sanders, Rogier W, Burton, Dennis R, Reincke, S Momsen, Prüss, Harald, Kreye, Jakob, Nemazee, David, Ward, Andrew B, Wilson, Ian A

“…Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike protein of wild-type severe acute respiratory syndrome coronavirus…”
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Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling by York, Autumn G., Williams, Kevin J., Argus, Joseph P., Zhou, Quan D., Brar, Gurpreet, Vergnes, Laurent, Gray, Elizabeth E., Zhen, Anjie, Wu, Nicholas C., Yamada, Douglas H., Cunningham, Cameron R., Tarling, Elizabeth J., Wilks, Moses Q., Casero, David, Gray, David H., Yu, Amy K., Wang, Eric S., Brooks, David G., Sun, Ren, Kitchen, Scott G., Wu, Ting-Ting, Reue, Karen, Stetson, Daniel B., Bensinger, Steven J.

“…Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I…”
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Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants by Lee, Juhye M., Huddleston, John, Doud, Michael B., Hooper, Kathryn A., Wu, Nicholas C., Bedford, Trevor, Bloom, Jesse D.

“…Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary success of influenza virus lineages…”
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Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine Immunogens by Zost, Seth J, Wu, Nicholas C, Hensley, Scott E, Wilson, Ian A

“…Abstract Influenza viruses routinely acquire mutations in their hemagglutinin (HA) and neuraminidase (NA) glycoproteins that abrogate binding of pre-existing…”
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Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution by Liang, Weiwen, Tan, Timothy J. C, Wang, Yiquan, Lv, Huibin, Sun, Yuanxin, Bruzzone, Roberto, Mok, Chris K. P, Wu, Nicholas C

“…Egg-adaptive mutations in influenza hemagglutinin (HA) often emerge during the production of egg-based seasonal influenza vaccines, which contribute to the…”
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Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity by Liu, Hejun, Wu, Nicholas C., Yuan, Meng, Bangaru, Sandhya, Torres, Jonathan L., Caniels, Tom G., van Schooten, Jelle, Zhu, Xueyong, Lee, Chang-Chun D., Brouwer, Philip J.M., van Gils, Marit J., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.

“…Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are specific to severe acute respiratory syndrome coronavirus 2…”
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Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure by Wu, Nicholas C, Wilson, Ian A

“…Hemagglutinin (HA) glycoprotein is an important focus of influenza research due to its role in antigenic drift and shift, as well as its receptor binding and…”
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Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections by Lv, Huibin, Wu, Nicholas C., Tsang, Owen Tak-Yin, Yuan, Meng, Perera, Ranawaka A.P.M., Leung, Wai Shing, So, Ray T.Y., Chan, Jacky Man Chun, Yip, Garrick K., Chik, Thomas Shiu Hong, Wang, Yiquan, Choi, Chris Yau Chung, Lin, Yihan, Ng, Wilson W., Zhao, Jincun, Poon, Leo L.M., Peiris, J.S. Malik, Wilson, Ian A., Mok, Chris K.P.

“…The World Health Organization has declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently…”
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Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020 by Perera, Ranawaka Apm, Mok, Chris Kp, Tsang, Owen Ty, Lv, Huibin, Ko, Ronald Lw, Wu, Nicholas C, Yuan, Meng, Leung, Wai Shing, Chan, Jacky Mc, Chik, Thomas Sh, Choi, Chris Yc, Leung, Kathy, Chan, Kin Ho, Chan, Karl Ck, Li, Ka-Chi, Wu, Joseph T, Wilson, Ian A, Monto, Arnold S, Poon, Leo Lm, Peiris, Malik

“…BackgroundThe ongoing coronavirus disease (COVID-19) pandemic has major impacts on health systems, the economy and society. Assessing infection attack rates in…”
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An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain by Wu, Nicholas C., Yuan, Meng, Liu, Hejun, Lee, Chang-Chun D., Zhu, Xueyong, Bangaru, Sandhya, Torres, Jonathan L., Caniels, Tom G., Brouwer, Philip J.M., van Gils, Marit J., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.

“…IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S)…”
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A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2 by Yin, Qian, Luo, Wei, Mallajosyula, Vamsee, Bo, Yang, Guo, Jing, Xie, Jinghang, Sun, Meng, Verma, Rohit, Li, Chunfeng, Constantz, Christian M., Wagar, Lisa E., Li, Jing, Sola, Elsa, Gupta, Neha, Wang, Chunlin, Kask, Oliver, Chen, Xin, Yuan, Xue, Wu, Nicholas C., Rao, Jianghong, Chien, Yueh-hsiu, Cheng, Jianjun, Pulendran, Bali, Davis, Mark M.

“…The ideal vaccine against viruses such as influenza and SARS-CoV-2 must provide a robust, durable and broad immune protection against multiple viral variants…”
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Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem by Lang, Shanshan, Xie, Jia, Zhu, Xueyong, Wu, Nicholas C., Lerner, Richard A., Wilson, Ian A.

“…Antibodies that target both group 1 and group 2 influenza A viruses are valuable for therapeutic and vaccine development, but only a few have been reported to…”
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Adaptation in protein fitness landscapes is facilitated by indirect paths by Wu, Nicholas C, Dai, Lei, Olson, C Anders, Lloyd-Smith, James O, Sun, Ren

“…The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to…”
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