Search Results - "Wu, Mack H."

Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction by Rigor, Robert R., Shen, Qiang, Pivetti, Christopher D., Wu, Mack H., Yuan, Sarah Y.

“…Microvascular barrier dysfunction is a serious problem that occurs in many inflammatory conditions, including sepsis, trauma, ischemia–reperfusion injury,…”
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Nonmuscle Myosin Light-Chain Kinase Deficiency Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice via Reduced Endothelial Barrier Dysfunction and Monocyte Migration by CHONGXIU SUN, WU, Mack H, YUAN, Sarah Y

“…Endothelial dysfunction and monocyte migration are key events in the pathogenesis of atherosclerosis. Nonmuscle myosin light-chain kinase (nmMLCK), the…”
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Molecular mechanisms of endothelial hyperpermeability: implications in inflammation by Kumar, Puneet, Shen, Qiang, Pivetti, Christopher D, Lee, Eugene S, Wu, Mack H, Yuan, Sarah Y

“…Endothelial hyperpermeability is a significant problem in vascular inflammation associated with trauma, ischaemia-reperfusion injury, sepsis, adult respiratory…”
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Gut Ischemia Reperfusion Injury Induces Lung Inflammation via Mesenteric Lymph-Mediated Neutrophil Activation by Ma, Yonggang, Zabell, Taylor, Creasy, Alexandra, Yang, Xiaoyuan, Chatterjee, Victor, Villalba, Nuria, Kistler, Erik B, Wu, Mack H, Yuan, Sarah Y

“…Gut ischemia/reperfusion (I/R) injury is a common clinical problem associated with significant mortality and morbidities that result from systemic inflammation…”
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TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells by Haines, Ricci J, Beard, Jr, Richard S, Eitner, Rebecca A, Chen, Liwei, Wu, Mack H

“…Since inflammatory bowel diseases (IBD) represent significant morbidity and mortality in the US, the need for defining novel drug targets and inflammatory…”
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DHHC21 deficiency attenuates renal dysfunction during septic injury by Yang, Xiaoyuan, Zheng, Ethan, Ma, Yonggang, Chatterjee, Victor, Villalba, Nuria, Breslin, Jerome W., Liu, Ruisheng, Wu, Mack H., Yuan, Sarah Y.

“…Renal dysfunction is one of the most common complications of septic injury. One critical contributor to septic injury-induced renal dysfunction is renal…”
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Endothelial focal adhesions and barrier function by Wu, Mack H.

“…Focal adhesions composed of integrins provide an important structural basis for anchoring the endothelial lining to its surrounding matrices in the vascular…”
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Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome by Beard, Richard S., Yang, Xiaoyuan, Meegan, Jamie E., Overstreet, Jonathan W., Yang, Clement G.Y., Elliott, John A., Reynolds, Jason J., Cha, Byeong J., Pivetti, Christopher D., Mitchell, David A., Wu, Mack H., Deschenes, Robert J., Yuan, Sarah Y.

“…Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing…”
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A Disintegrin and Metalloproteinase 15 Contributes to Atherosclerosis by Mediating Endothelial Barrier Dysfunction via Src Family Kinase Activity by Sun, Chongxiu, Wu, Mack H, Lee, Eugene S, Yuan, Sarah Y

“…OBJECTIVE—Endothelium dysfunction is an initiating factor in atherosclerosis. A disintegrin and metalloproteinase 15 (ADAM 15) is a multidomain metalloprotease…”
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Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments by Guo, Xiaohua, Eitnier, Rebecca A, Beard, Jr, Richard S, Meegan, Jamie E, Yang, Xiaoyuan, Aponte, Alexandra M, Wang, Fang, Nelson, Peter R, Wu, Mack H

“…We previously reported microvascular leakage resulting from fibrinogen-γ chain C-terminal products (γC) occurred via a RhoA-dependent mechanism. The objective…”
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MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression by Chatterjee, Victor, Beard, Jr, Richard S, Reynolds, Jason J, Haines, Ricci, Guo, Mingzhang, Rubin, Matthew, Guido, Jenny, Wu, Mack H, Yuan, Sarah Y

“…A disintegrin and metalloproteinase15 (ADAM15) has been shown to be upregulated and mediate endothelial hyperpermeability during inflammation and sepsis. This…”
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Neutrophil transmigration, focal adhesion kinase and endothelial barrier function by Yuan, Sarah Y., Shen, Qiang, Rigor, Robert R., Wu, Mack H.

“…Neutrophil activation is an essential component of innate immune defense against infection and injury. In response to inflammatory stimulation, circulating…”
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Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism by Breslin, Jerome W, Gaudreault, Nathalie, Watson, Katherine D, Reynoso, Rashell, Yuan, Sarah Y, Wu, Mack H

“…Vascular endothelial growth factor (VEGF)-C plays an important role in lymphangiogenesis; however, functional responses of lymphatic vessels to VEGF-C have not…”
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Protein palmitoylation regulates extracellular vesicle production and function in sepsis by Yang, Xiaoyuan, Zheng, Ethan, Chatterjee, Victor, Ma, Yonggang, Reynolds, Amanda, Villalba, Nuria, Wu, Mack H., Yuan, Sarah Y.

“…Extracellular vesicles (EVs) are bioactive membrane‐encapsulated particles generated by a series of events involving membrane budding, fission and fusion…”
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Tissue inhibitor of metalloproteinase-2 regulates matrix metalloproteinase-2-mediated endothelial barrier dysfunction and breast cancer cell transmigration through lung microvascular endothelial cells by Shen, Qiang, Lee, Eugene S, Pitts, Robert L, Wu, Mack H, Yuan, Sarah Y

“…Matrix metalloproteinases (MMP) have been implicated in multiple stages of cancer metastasis. Tissue inhibitor of metalloproteinase-2 (TIMP-2) plays an…”
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Rnd3 as a Novel Target to Ameliorate Microvascular Leakage by Breslin, Jerome W., Daines, Dayle A., Doggett, Travis M., Kurtz, Kristine H., Souza‐Smith, Flavia M., Zhang, Xun E., Wu, Mack H., Yuan, Sarah Y.

“…Background Microvascular leakage of plasma proteins is a hallmark of inflammation that leads to tissue dysfunction. There are no current therapeutic strategies…”
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Toll-like receptor 4 contributes to microvascular inflammation and barrier dysfunction in thermal injury by Breslin, Jerome W, Wu, Mack H, Guo, Mingzhang, Reynoso, Rashell, Yuan, Sarah Y

“…Systemic and microvascular inflammation plays a key role in the development of multiple organ failure after infection, sepsis, and traumatic injury. Toll-like…”
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Extracellular vesicles: new players in regulating vascular barrier function by Chatterjee, Victor, Yang, Xiaoyuan, Ma, Yonggang, Wu, Mack H, Yuan, Sarah Y

“…Extracellular vesicles (EVs) have attracted rising interests in the cardiovascular field not only because they serve as serological markers for circulatory…”
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The Gut-Lung Axis in Systemic Inflammation. Role of Mesenteric Lymph as a Conduit by Ma, Yonggang, Yang, Xiaoyuan, Chatterjee, Victor, Wu, Mack H, Yuan, Sarah Y

“…Emerging evidence shows that after injury or infection, the mesenteric lymph acts as a conduit for gut-derived toxic factors to enter the blood circulation,…”
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Eph B4 Receptor Signaling Mediates Endothelial Cell Migration and Proliferation via the Phosphatidylinositol 3-Kinase Pathway by Steinle, Jena J, Meininger, Cynthia J, Forough, Reza, Wu, Guoyao, Wu, Mack H, Granger, Harris J

“…The goals of this study were 2-fold: 1) to determine whether stimulation of Eph B4 receptors promotes microvascular endothelial cell migration and/or…”
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