Search Results - "Wu, Kay L.H"

Oxidative Impairment of Mitochondrial Electron Transport Chain Complexes in Rostral Ventrolateral Medulla Contributes to Neurogenic Hypertension by Chan, Samuel H.H, Wu, Kay L.H, Chang, Alice Y.W, Tai, Ming-Hon, Chan, Julie Y.H

“…The role for mitochondrial electron transport chain (ETC) in neurogenic hypertension is unidentified. We evaluated the hypothesis that feedforward depression…”
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Transcriptional Upregulation of Mitochondrial Uncoupling Protein 2 Protects Against Oxidative Stress-Associated Neurogenic Hypertension by Chan, Samuel H.H, Wu, Chiung-Ai, Wu, Kay L.H, Ho, Ying-Hao, Chang, Alice Y.W, Chan, Julie Y.H

“…RATIONALE:Mitochondrial uncoupling proteins (UCPs) belong to a superfamily of mitochondrial anion transporters that uncouple ATP synthesis from oxidative…”
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Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle by Lee, Wei-Chia, Yu, Hong-Ren, Tain, You-Lin, Wu, Kay L.H, Chuang, Yao-Chi, Chan, Julie Y.H

“…Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder…”
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Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation by Wu, Kay L.H., Wu, Chih-Wei, Chao, Yung-Mei, Hung, Chun-Ying, Chan, Julie Y.H.

“…Oxidative stress in rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, is involved in the development of hypertension under…”
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Maternal fructose-intake-induced renal programming in adult male offspring by Tain, You-Lin, Wu, Kay L.H., Lee, Wei-Chia, Leu, Steve, Chan, Julie Y.H.

“…Nutrition in pregnancy can elicit long-term effects on the health of offspring. Although fructose consumption has increased globally and is linked to metabolic…”
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Targeting arachidonic acid pathway to prevent programmed hypertension in maternal fructose-fed male adult rat offspring by Tain, You-Lin, Lee, Wei-Chia, Wu, Kay L.H., Leu, Steve, Chan, Julie Y.H.

“…Hypertension can be programmed in response to nutritional insults in early life. Maternal high-fructose (HF) intake induced programmed hypertension in adult…”
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Expression of pro-inflammatory cytokine and caspase genes promotes neuronal apoptosis in pontine reticular formation after spinal cord transection by Wu, Kay L.H, Chan, Samuel H.H, Chao, Yung-Mei, Chan, Julie Y.H

“…We identified apoptotic neurons in pontine reticular formation (PRF), the origin of pontine reticulospinal fibers, in adult Sprague–Dawley rats after complete…”
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Impaired insulin signaling at the bladder mucosa facilitates metabolic syndrome-associated bladder overactivity in rats with maternal and post-weaning fructose exposure by Lee, Wei-Chia, Wu, Kay L.H., Tain, You-Lin, Leu, Steve, Cheng, Yuan-Tso, Chan, Julie Y.H.

“…Metabolic syndrome (MetS) and overactive bladder might share common pathophysiologies. Environmental fructose exposure during pre- and postnatal periods of…”
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Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome by Wu, Kay L.H, Chao, Yung-Mei, Tsay, Shiow-Jen, Chen, Chen Hsiu, Chan, Samuel H.H, Dovinova, Ima, Chan, Julie Y.H

“…Metabolic syndrome (MetS), which is rapidly becoming prevalent worldwide, is long known to be associated with hypertension and recently with oxidative stress…”
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Recessively‐Inherited Adult‐Onset Alexander Disease Caused by a Homozygous Mutation in the GFAP Gene by Fu, Mu‐Hui, Chang, Yung‐Yee, Lin, Ni‐Hsuan, Yang, Ai‐Wen, Chang, Chiung‐Chih, Liu, Jia‐Shou, Peng, Cheng‐Huei, Wu, Kay, L.H., Perng, Ming‐Der, Lan, Min‐Yu

“…Background Alexander disease (AxD) is an autosomal‐dominant leukodystrophy caused by heterozygous mutations in the glial fibrillary acidic protein (GFAP) gene…”
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Translational insights on developmental origins of metabolic syndrome: Focus on fructose consumption by Lee, Wei-Chia, Wu, Kay L H, Leu, Steve, Tain, You-Lin

“…Metabolic syndrome (MetS) is a highly prevalent complex trait despite recent advances in pathophysiology and pharmacological treatment. MetS can begin in early…”
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Effect of three clinical therapies on cytokines modulation in the hip articular cartilage and bone improvement in rat early osteonecrosis of the femoral head by Hsu, Shan-Ling, Jhan, Shun-Wun, Hsu, Chieh-Cheng, Wu, Yi-No, Wu, Kay L H, Kuo, Chun-En Aurea, Chiu, Hung-Wen, Cheng, Jai-Hong

“…Extracorporeal shockwave therapy (ESWT) and adipose-derived mesenchymal stem cells (ADSCs) have been used clinically for the treatment of osteonecrosis of the…”
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Environmental stimulation rescues maternal high fructose intake-impaired learning and memory in female offspring: Its correlation with redistribution of histone deacetylase 4 by Wu, Kay L.H., Wu, Chih-Wei, Tain, You-Lin, Huang, Li-Tung, Chao, Yung-Mei, Hung, Chun-Ying, Wu, Jin-Cheng, Chen, Siang-Ru, Tsai, Pei-Chia, Chan, Julie Y.H.

“…•Adult female offspring shows impaired cognition to maternal high fructose diet.•Suppression of hippocampal BDNF contributes to the programmed deficit of…”
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High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K/AKT/mitochondria signaling by Chang, Hsiao-Huang, Lin, I-Chun, Wu, Chih-Wei, Hung, Chun-Ying, Liu, Wen-Chung, Wu, Cai-Yi, Cheng, Ching-Li, Wu, Kay L H

“…BACKGROUNDAortic valve stenosis (AS) is a common, lethal cardiovascular disease. There is no cure except the valve replacement at last stage. Therefore, an…”
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Oral Intake of Rosiglitazone Promotes a Central Antihypertensive Effect Via Upregulation of Peroxisome Proliferator-Activated Receptor-γ and Alleviation of Oxidative Stress in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats by Chan, Samuel H.H, Wu, Kay L.H, Kung, Peter S.S, Chan, Julie Y.H

“…Rosiglitazone, a synthetic ligand of transcription factor peroxisome proliferator-activated receptor-γ (PPAR-γ), possesses a blood pressure–lowering effect…”
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Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats by Wu, Kay L H, Wu, Chiung-Ai, Wu, Chih-Wei, Chan, Samuel H H, Chang, Alice Y W, Chan, Julie Y H

“…The activity of phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (Akt) is enhanced under hypertension. The phosphatase and tensin homolog…”
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Brain mitochondrial biogenesis and bioenergetics in autonomic regulation of blood pressure: Significance in metabolic syndrome by Wu, Kay L.H, Chan, Samuel H.H, Chan, Julie Y.H

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F-002 CYCLOOXYGENASE-2-DEPENDENT NEUROINFLAMMATION AND OXIDATIVE STRESS IN ROSTRAL VENTROLATERAL MEDULLA CONTRIBUTE TO NEUROGENIC HYPERTENSION FOLLOWING PERIPHERAL INFLAMMATION by Wu, Kay L.H, Chan, Julie Y.H

“…BACKGROUNDPeripheral inflammation plays a significant role in pathogenesis of hypertension and the associated cardiovascular complications. The purpose of this…”
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Nitric oxide and superoxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translocation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury by Wu, Kay L H, Hsu, Chin, Chan, Julie Y H

“…We reported previously that complete spinal cord transection (SCT) results in depression of mitochondrial respiratory chain enzyme activity that triggers…”
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Maternal fructose exposure programs metabolic syndrome-associated bladder overactivity in young adult offspring by Lee, Wei-Chia, Tain, You-Lin, Leu, Steve, Wu, Kay L.H., Chan, Julie Y.H.

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