Search Results - "Wu, Julie J"

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression by Wu, J. Julie, Liu, Jie, Chen, Edmund B., Wang, Jennifer J., Cao, Liu, Narayan, Nisha, Fergusson, Marie M., Rovira, Ilsa I., Allen, Michele, Springer, Danielle A., Lago, Cory U., Zhang, Shuling, DuBois, Wendy, Ward, Theresa, deCabo, Rafael, Gavrilova, Oksana, Mock, Beverly, Finkel, Toren

“…We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but…”
Get full text

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency by Cao, Liu, Xu, Xioaling, Bunting, Samuel F., Liu, Jie, Wang, Rui-Hong, Cao, Longyue L., Wu, J. Julie, Peng, Tie-Nan, Chen, Junjie, Nussenzweig, Andre, Deng, Chu-Xia, Finkel, Toren

“…The molecular pathways leading from genomic instability to cellular senescence and/or cell death remain incompletely characterized. Using mouse embryonic…”
Get full text

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy by Wu, J Julie, Quijano, Celia, Chen, Edmund, Liu, Hongjun, Cao, Liu, Fergusson, Maria M, Rovira, Ilsa I, Gutkind, Sarah, Daniels, Mathew P, Komatsu, Masaaki, Finkel, Toren

“…Impaired or deficient autophagy is believed to cause or contribute to aging, as well as a number of age-related pathologies. The exact mechanism through which…”
Get full text

Dynamic Regulation of Pro- and Anti-Inflammatory Cytokines by MAPK Phosphatase 1 (MKP-1) in Innate Immune Responses by Chi, Hongbo, Barry, Sean P., Roth, Rachel J., Wu, J. Julie, Jones, Elizabeth A., Bennett, Anton M., Flavell, Richard A.

“…Engagement of Toll-like receptors (TLRs) on macrophages leads to activation of the mitogen-activated protein kinases (MAPKs), which contribute to innate immune…”
Get full text

Earnings Attribution and Information Transfers by Koo, David S., Julie Wu, J., Yeung, P. Eric

“…Managers frequently attribute the news in their earnings forecasts to various economic events. Using textual analysis, we identify the economic factors…”
Get full text

Essential Role for Mitogen-activated Protein (MAP) Kinase Phosphatase-1 in Stress-responsive MAP Kinase and Cell Survival Signaling by Wu, J. Julie, Bennett, Anton M.

“…Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) constitute a family of 11 dual-specificity phosphatases that inactivate the MAPKs by…”
Get full text

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity by Wu, J. Julie, Roth, Rachel J., Anderson, Ethan J., Hong, Eun-Gyoung, Lee, Mi-Kyung, Choi, Cheol Soo, Neufer, P. Darrell, Shulman, Gerald I., Kim, Jason K., Bennett, Anton M.

“…The mitogen-activated protein kinases (MAPK) play critical roles in the pathogenesis of diabetes and obesity. The MAPKs are inactivated by MAPK phosphatases…”
Get full text

Metabolism meets autophagy by Wu, J. Julie, Quijano, Celia, Wang, Jiamei, Finkel, Toren

“…Comment on: Wu, et al. Aging 2009; 1:425-37…”
Get full text

The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase Phosphatase 1 Directs Nuclear Targeting and Serum Response Element Transcriptional Regulation by Wu, J. Julie, Zhang, Lei, Bennett, Anton M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Epidermal Growth Factor-mediated Activation of the ETS Domain Transcription Factor Elk-1 Requires Nuclear Calcium by Pusl, Thomas, Wu, Julie J., Zimmerman, Tracy L., Zhang, Lei, Ehrlich, Barbara E., Berchtold, Martin W., Hoek, Joannes B., Karpen, Saul J., Nathanson, Michael H., Bennett, Anton M.

“…Cytosolic and nuclear Ca2+ have been shown to differentially regulate transcription. However, the impact of spatially distinct Ca2+ signals on…”
Get full text

Wnt signaling regulates hepatic metabolism by Liu, Hongjun, Fergusson, Maria M, Wu, J Julie, Rovira, Ilsa I, Liu, Jie, Gavrilova, Oksana, Lu, Teng, Bao, Jianjun, Han, Donghe, Sack, Michael N, Finkel, Toren

“…The contribution of the Wnt pathway has been extensively characterized in embryogenesis, differentiation, and stem cell biology but not in mammalian…”
Get more information

Cardiac-Specific Overexpression of Peroxisome Proliferator–Activated Receptor-α Causes Insulin Resistance in Heart and Liver by PARK, So-Young, CHO, You-Ree, WU, Julie J, BENNETT, Anton M, ROTHERMEL, Beverly, KAFINOWSKI, April, RUSSELL, Kerry S, KIM, Young-Bum, KELLY, Daniel P, KIM, Jason K, FINCK, Brian N, KIM, Hyo-Jeong, HIGASHIMORI, Takamasa, HONG, Eun-Gyoung, LEE, Mi-Kyung, DANTON, Cheryl, DESHMUKH, Swati, CLINE, Gary W

“…Cardiac-Specific Overexpression of Peroxisome Proliferator–Activated Receptor-α Causes Insulin Resistance in Heart and Liver So-Young Park 1 , You-Ree Cho 1 ,…”
Get full text

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging following genetic reduction of mTOR expression by Wu, J. Julie, Liu, Jie, Chen, Edmund B., Wang, Jennifer J., Cao, Liu, Narayan, Nisha, Fergusson, Marie M., Rovira, Ilsa I., Allen, Michele, Springer, Danielle A., Lago, Cory U., Zhang, Shuling, DuBois, Wendy, Ward, Theresa, deCabo, Rafael, Gavrilova, Oksana, Mock, Beverly, Finkel, Toren

“…We analyzed a new hypomorphic mouse model containing a targeted intronic insertion of a neomycin cassette within the mechanistic target of rapamycin (mTOR)…”
Get full text

Increased expression of estrogen receptor beta in human uterine smooth muscle at term by Wu, JJ, Geimonen, E, Andersen, J

“…Expression of the cx43 gene for the gap junction protein, connexin43 (Cx43), through activator protein (AP)-1 activity has been shown to be inhibited in human…”
Get full text

Differential role of beta(1C) and beta(1A) integrin cytoplasmic variants in modulating focal adhesion kinase, protein kinase B/AKT, and Ras/Mitogen-activated protein kinase pathways by Fornaro, M, Steger, C A, Bennett, A M, Wu, J J, Languino, L R

“…The integrin cytoplasmic domain modulates cell proliferation, adhesion, migration, and intracellular signaling. The beta(1) integrin subunits, beta(1C) and…”
Get full text

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-[alpha] causes insulin resistance in heart and liver by Park, So-Young, Cho, You-Ree, Finck, Brian N, Kim, Hyo-Jeong, Higashimori, Takamasa, Hong, Eun-Gyoung, Lee, Mi-Kyung, Danton, Cheryl, Deshmukh, Swati, Cline, Gary W, Wu, Julie J, Bennett, Anton M, Rothermel, Beverly, Kalinowski, April, Russell, Kerry S, Kim, Young-Bum, Kelly, Daniel P, Kim, Jason K

“…Diabetic heart failure may be causally associated with alterations in cardiac energy metabolism and insulin resistance. Mice with heart-specific overexpression…”
Get full text

Differential Role of β 1C and β 1A Integrin Cytoplasmic Variants in Modulating Focal Adhesion Kinase, Protein Kinase B/AKT, and Ras/Mitogen-activated Protein Kinase Pathways by Fornaro, Mara, Steger, Craig A., Bennett, Anton M., Wu, J. Julie, Languino, Lucia R.

“…The integrin cytoplasmic domain modulates cell proliferation, adhesion, migration, and intracellular signaling. The β 1 integrin subunits, β 1C and β 1A , that…”
Get full text

Differential Role of β1C and β1A Integrin Cytoplasmic Variants in Modulating Focal Adhesion Kinase, Protein Kinase B/AKT, and Ras/Mitogen-activated Protein Kinase Pathways by Fornaro, Mara, Steger, Craig A., Bennett, Anton M., Wu, J. Julie, Languino, Lucia R.

“…The integrin cytoplasmic domain modulates cell proliferation, adhesion, migration, and intracellular signaling. The β 1 integrin subunits, β 1C and β 1A , that…”
Get full text