Search Results - "Wu, Judy Qiju"

Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era by Wu, Judy Qiju, Kornbluth, Sally

“…Vertebrate eggs are arrested at the metaphase stage of meiosis II. Only upon fertilization will the metaphase-II-arrested eggs exit meiosis II and enter…”
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CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles by Jin, Yiru, Basu, Somrita, Feng, Mei, Ning, Yu, Munasinghe, Indeewara, Joachim, Arline M., Li, Junan, Qin, Lingli, Madden, Robert, Burks, Hannah, Gao, Philip, Wu, Judy Qiju, Sheikh, Salma Waheed, Joice, April C., Perera, Chamani, Werbovetz, Karl A., Zhang, Kai, Wang, Michael Zhuo

“…Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity…”
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PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation by Chen, Chen, Kornbluth, Sally, Nairn, Angus C, Wu, Judy Qiju, Tang, Wanli, Freel, Christopher D, Yang, Chih-Sheng, Guo, Jessie Yanxiang

“…Loss of cell division cycle 2 (Cdc2, also known as Cdk1) activity after cyclin B degradation is necessary, but not sufficient, for mitotic exit. Proteins…”
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A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes by Wang, Michael Zhuo, Wu, Judy Qiju, Dennison, Jennifer B., Bridges, Arlene S., Hall, Stephen D., Kornbluth, Sally, Tidwell, Richard R., Smith, Philip C., Voyksner, Robert D., Paine, Mary F., Hall, James Edwin

“…The human cytochrome P450 (P450) superfamily consists of membrane‐bound proteins that metabolize a myriad of xenobiotics and endogenous compounds…”
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Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine by WANG, Michael Zhuo, WU, Judy Qiju, BRIDGES, Arlene S, ZELDIN, Darryl C, KORNBLUTH, Sally, TIDWELL, Richard R, HALL, James Edwin, PAINE, Mary F

“…CYP4F enzymes, including CYP4F2 and CYP4F3B, were recently shown to be the major enzymes catalyzing the initial oxidative O -demethylation of the antiparasitic…”
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Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A by Wu, Judy Qiju, Hansen, David V, Guo, Yanxiang, Wang, Michael Zhuo, Tang, Wanli, Freel, Christopher D, Tung, Jeffrey J, Jackson, Peter K, Kornbluth, Sally

“…Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive…”
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Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism by Tang, Wanli, Wu, Judy Qiju, Chen, Chen, Yang, Chih-Sheng, Guo, Jessie Yanxiang, Freel, Christopher D, Kornbluth, Sally

“…Vertebrate eggs are arrested at Metaphase II by Emi2, the meiotic anaphase-promoting complex/cyclosome (APC/C) inhibitor. Although the importance of Emi2…”
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Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition by Tang, Wanli, Wu, Judy Qiju, Guo, Yanxiang, Hansen, David V, Perry, Jennifer A, Freel, Christopher D, Nutt, Leta, Jackson, Peter K, Kornbluth, Sally

“…The transition of oocytes from meiosis I (MI) to meiosis II (MII) requires partial cyclin B degradation to allow MI exit without S phase entry. Rapid…”
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Pharmacogenomics education strategies in the United States pharmacy school curricula by Wu, Judy Qiju, Wang, Michael Zhuo, Bates, Jessica, Shaddock, Rachel E., Wiisanen, Kristin

“…Clinical pharmacogenomics is an expanding area in healthcare that relies heavily on pharmacists for advocacy and implementation. To support pharmacists'…”
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Development of an In Vitro Model to Screen CYP1B1-Targeted Anticancer Prodrugs by Wang, Zhiying, Chen, Yao, Drbohlav, Laura M, Wu, Judy Qiju, Wang, Michael Zhuo

“…Cytochrome P450 1B1 (CYP1B1) is an anticancer therapeutic target due to its overexpression in a number of steroid hormone-related cancers. One anticancer drug…”
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Not-So-Pseudo a Substrate: Acm1-Mediated Inhibition of the APC by Wu, Judy Qiju, Kornbluth, Sally

“…In a recent issue of Molecular Cell, Enquist-Newman et al. (2008) demonstrate that Acm1 is ubiquitinated by APC Cdc20. By contrast, the high-affinity…”
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Aven-Dependent Activation of ATM Following DNA Damage by Guo, Jessie Yanxiang, Yamada, Ayumi, Kajino, Taisuke, Wu, Judy Qiju, Tang, Wanli, Freel, Christopher D., Feng, Junjie, Chau, B. Nelson, Wang, Michael Zhuo, Margolis, Seth S., Yoo, Hae Yong, Wang, Xiao-Fan, Dunphy, William G., Irusta, Pablo M., Hardwick, J. Marie, Kornbluth, Sally

“…In response to DNA damage, cells undergo either cell-cycle arrest or apoptosis, depending on the extent of damage and the cell's capacity for DNA repair…”
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