Search Results - "Wu, Jogin R"

Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram by Machlus, Kellie R, Colby, Emily A, Wu, Jogin R, Koch, Gary G, Key, Nigel S, Wolberg, Alisa S

“…Elevated procoagulant levels have been correlated with increased thrombin generation in vitro and with increased venous thromboembolism (VTE) risk in…”
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Multicenter evaluation of a new quantitative highly sensitive D-dimer assay, the Hemosil® D-dimer HS 500, in patients with clinically suspected venous thromboembolism by Legnani, Cristina, Cini, Michela, Scarvelis, Dimitrios, Toulon, Pierre, Wu, Jogin R, Palareti, Gualtiero

“…Abstract Introduction D-dimer testing is widely used in conjunction with clinical pretest probability (PTP) for venous thromboembolism (VTE) exclusion. We…”
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Evaluation of the Stratus® CS Acute Care™ D-dimer assay (DDMR) using the Stratus® CS STAT Fluorometric Analyzer: A prospective multisite study for exclusion of pulmonary embolism and deep vein thrombosis by Gosselin, Robert C, Wu, Jogin R, Kottke-Marchant, Kandice, Peetz, Dirk, Christie, Douglas J, Muth, Heidrun, Panacek, Edward

“…Abstract Background D-dimer testing is an integral part of the diagnostic algorithm in excluding patients with venous thromboembolism. In this study, we…”
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Clinical evaluation of a new functional test for detection of activated protein C resistance (Pefakit® APC-R Factor V Leiden) at two centers in Europe and the USA by Schöni, Reto, Quehenberger, Peter, Wu, Jogin R, Wilmer, Marianne

“…Abstract A new clotting assay, Pefakit® APC-R Factor V Leiden (Pentapharm Ltd., Switzerland), for the detection of an increased resistance of coagulation…”
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Comparison of optical and mechanical clot detection for routine coagulation testing in a large volume clinical laboratory by Bai, Bing, Christie, Douglas J, Gorman, Robert T, Wu, Jogin R

“…Hemostasis instrumentation has rapidly advanced and laboratories are demanding fully automated coagulation systems. Two distinct technological families exist…”
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Mechanism of poly(ethylene glycol)-induced lipid transfer between phosphatidylcholine large unilamellar vesicles: a fluorescent probe study by Wu, Jogin R, Lentz, Barry R

“…Experiments were performed to assess three possible mechanisms of poly(ethylene glycol) (PEG) induced rapid lipid transfer between large unilamellar vesicles…”
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Role of procoagulant lipids in human prothrombin activation. 1. Prothrombin activation by factor X(a) in the absence of factor V(a) and in the absence and presence of membranes by Wu, Jogin R, Zhou, Chaoming, Majumder, Rinku, Powers, Daniel D, Weinreb, Gabriel, Lentz, Barry R

“…Activation of prothrombin by factor X(a) requires proteolysis of two bonds and is commonly assumed to occur via by two parallel, sequential pathways…”
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Phospholipid-specific conformational changes in human prothrombin upon binding to procoagulant acidic lipid membranes by Wu, J R, Lentz, B R

“…This paper provides evidence to demonstrate that human prothrombin undergoes conformational changes upon binding to procoagulant membranes specifically…”
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Role of Procoagulant Lipids in Human Prothrombin Activation. 1. Prothrombin Activation by Factor Xa in the Absence of Factor Va and in the Absence and Presence of Membranes by Wu, Jogin R, Zhou, Chaoming, Majumder, Rinku, Powers, Daniel D, Weinreb, Gabriel, Lentz, Barry R

“…Activation of prothrombin by factor Xa requires proteolysis of two bonds and is commonly assumed to occur via by two parallel, sequential pathways. Hydrolysis…”
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Effect of Plasmatic Procoagulant Factors in Thrombin Generation Parameters in a Platelet-Poor Plasma Model System by Wu, Jogin R., Bai, Bing

“…The evolution of the thrombin generation (TG) concept and the recent technical advances in automated TG measurement have made its clinical utility practical…”
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Phosphatidylserine-Containing Membranes Alter the Thermal Stability of Prothrombin's Catalytic Domain: A Differential Scanning Calorimetric Study by Lentz, Barry R, Zhou, Chao-Ming, Wu, Jogin R

“…Denaturation profiles of bovine prothrombin and its isolated fragments were examined in the presence of Na2EDTA, 5 mM CaCl2, and CaCl2 plus membranes…”
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Cryptic D-Dimer Antigen: A Sensitive Marker of Factor XIIIa Activity during Intravascular Coagulation by Suwanawiboon, Bundarika, Haroon, Zishan A., Lai, Thung S., Wu, Jogin R., Greenberg, Charles S.

“…FactorXIIIa (FXIIIa) plays an important role in regulating hemostatic and thrombotic events. FXIIIa modifies the structure of fibrin making the insoluble…”
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Insights into the complex association of bovine factor Va with acidic-lipid-containing synthetic membranes by Cutsforth, G.A., Koppaka, V., Krishnaswamy, S., Wu, J.R., Mann, K.G., Lentz, B.R.

“…The mechanism of binding of blood coagulation cofactor factor Va to acidic-lipid-containing membranes has been addressed. Binding isotherms were generated at…”
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The interfacial region of dipalmitoylphosphatidylcholine bilayers is perturbed by fusogenic amphipaths by Lentz, B.R., Wu, J.R., Zheng, L., Prevrátil, J.

“…Several structural methods were used to probe the influence of three fusogenic and four nonfusogenic amphipaths on large, unilamellar…”
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A method for quantitative interpretation of fluorescence detection of poly(ethylene glycol)-mediated 1-palmitoyl-2-[[[2-[4-(phenyl-trans-1,3,5-hexatrienyl) phenyl]ethyl]oxyl]carbonyl]3-sn-phosphatidylcholine (DPHpPC) transfer and fusion between phospholipid vesicles in the dehydrated state by Wu, J R, Lentz, B R

“…A method has been developed for calculating the expected fluorescence lifetime of the DPH p PC probe distributed between different membrane environments. We…”
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Membrane binding induces lipid-specific changes in the denaturation profile of bovine prothrombin. A scanning calorimetry study by Lentz, B.R., Wu, J.R., Sorrentino, A.M., Carleton, J.N.

“…Prothrombin denaturation was examined in the presence of Na2EDTA, 5mM CaCl2, and CaCl2 plus membranes containing 1-palmitoyl-2-oleoyl-3-sn-phosphatidylcholine…”
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Determination of the rate of rapid lipid transfer induced by poly(ethylene glycol) using the SLM Fourier transform phase and modulation spectrofluorometer by Burgess, S W, Wu, J R, Swift, K, Lentz, B R

“…Rate constants were determined for the transfer of the fluorescent lipid probe 1-palmitoyl-2-[[2-[4-(6-phenyl-trans-1,3,5-hexatrienyl)phenyl]ethyl]…”
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