Search Results - "Wu, Jiacai"

Histone H3R17me2a mark recruits human RNA Polymerase-Associated Factor 1 Complex to activate transcription by Wu, Jiacai, Xu, Wei

“…The histone coactivator-associated arginine methyltransferase 1 (CARM1) is a coactivator for a number of transcription factors, including nuclear receptors…”
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Cell-Derived Vesicles for mRNA Delivery by Li, Zhenghua, Liu, Zhen, Wu, Jiacai, Li, Bin

“…The clinical translation of messenger mRNA (mRNA)-based therapeutics requires safe and effective delivery systems. Although considerable progress has been made…”
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TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks by Yang, Yanzhong, Lu, Yue, Espejo, Alexsandra, Wu, Jiacai, Xu, Wei, Liang, Shoudan, Bedford, Mark T.

“…Specific sites of histone tail methylation are associated with transcriptional activity at gene loci. These methyl marks are interpreted by effector molecules,…”
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Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway by Wang, Juan, Huang, Fengxiang, Bai, Zhun, Chi, Bixia, Wu, Jiacai, Chen, Xu

“…Curcumol, isolated from the traditional medical plant Rhizoma Curcumae, is the bioactive component of Zedoary oil, whose potential anti-tumor effect has…”
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Incidence, associated factors, and outcomes of delirium in critically ill children in china: a prospective cohort study by Lei, Lei, Li, Yi, Xu, Huilin, Zhang, Qin, Wu, Jiacai, Zhao, Shoujv, Zhang, Xiaochao, Xu, Min, Zhang, Shuai

“…Delirium occurs frequently in critically ill children and has been reported in many countries, but delirium is not well-characterized in China. The aim of this…”
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Review of conformal cooling system design and additive manufacturing for injection molds by Wei, Zhihao, Wu, Jiacai, Shi, Nan, Li, Lei

“…This paper points out the significance of cooling in injection molding and briefly reviews the development of cooling systems. The focus of this survey is on…”
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CARM1 Is an Important Determinant of ERα-Dependent Breast Cancer Cell Differentiation and Proliferation in Breast Cancer Cells by AL-DHAHERI, Mariam, JIACAI WU, WEI XU, SKLIRIS, Georgios P, JUN LI, HIGASHIMATO, Ken, YIDAN WANG, WHITE, Kevin P, LAMBERT, Paul, YUERONG ZHU, MURPHY, Leigh

“…Breast cancers with estrogen receptor α (ERα) expression are often more differentiated histologically than ERα-negative tumors, but the reasons for this…”
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Human amniotic epithelial cells ameliorate behavioral dysfunction and reduce infarct size in the rat middle cerebral artery occlusion model by Liu, Tianjin, Wu, Jiacai, Huang, Qin, Hou, Yanan, Jiang, Zhihua, Zang, Shaoyun, Guo, Lihe

“…Human amniotic epithelial cells (hAECs), having the characteristics of both embryonic and pluripotent stem cells, have the potential to differentiate into…”
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Chimeric antigen receptor therapy meets mRNA technology by Wu, Jiacai, Wu, Weigang, Zhou, Boping, Li, Bin

“…Chimeric antigen receptor (CAR) T therapy is a game changer in cancer immunotherapy and beyond.CAR natural killer (NK) cells and CAR macrophages show…”
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Structural differences of polysaccharides from Astragalus before and after honey processing and their effects on colitis mice by Wu, Jiacai, Li, Chanyi, Bai, Lisha, Wu, Jian, Bo, Rui, Ye, Mingzhu, Huang, Li, Chen, Hongyuan, Rui, Wen

“…Honey-processed Astragalus is a dosage form of Radix Astragali processed with honey, which exhibits better efficacy of tonifying Qi than the raw product…”
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A metabonomics and lipidomics based network pharmacology study of qi-tonifying effects of honey-processed Astragalus on spleen qi deficiency rats by Huang, Li, Ye, Mingzhu, Wu, Jiacai, Liu, Wuping, Chen, Hongyuan, Rui, Wen

“…Work flow of the metabonomics and lipidomics based network pharmacology study on the pharmacodynamic mechanism of honey-processed Astragalus. [Display omitted]…”
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PDLIM7 Promotes Tumor Metastasis in Papillary Thyroid Carcinoma via Stabilizing Focal Adhesion Kinase Protein by Yang, Fan, Yang, Mingqing, Liu, Yi, Zhou, Chen, Chen, Yongbei, Wu, Jiacai, Zhang, Xiaoling, Xiao, Shengjun

“…As an actin cytoskeleton interactor, PDZ (postsynaptic density 65-discs large-zonula occludens 1) and LIM (abnormal cell lineage 11-isket 1-mechanosensory…”
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Structural changes of polysaccharides from Astragulus after honey processing and their bioactivities on human gut microbiota by Tian, Yufei, Wu, Jiacai, Zheng, Yili, Li, Mengyu, Xu, Xia, Chen, Hongyuan, Rui, Wen

“…BACKGROUND Astragali Radix (also known as Astragulus) is a traditional medicinal and edible homologous plant for tonifying Qi. Honey‐processed Astragalus is a…”
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Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells by Wang, Juan, Wu, Jiacai, Li, Xumei, Liu, Haowei, Qin, Jianli, Bai, Zhun, Chi, Bixia, Chen, Xu

“…Identification of the specific protein target(s) of a drug is a critical step in unraveling its mechanisms of action (MOA) in many natural products. Curcumol,…”
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Quaternization drives spleen-to-lung tropism conversion for mRNA-loaded lipid-like nanoassemblies by Huang, Yixuan, Wu, Jiacai, Li, Sanpeng, Liu, Zhen, Li, Zhenghua, Zhou, Boping, Li, Bin

“…As the overwhelming majority of advanced mRNA delivery systems are preferentially accumulated in the liver, there is an accelerating growth in the demand for…”
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Strategies for determining the bioactive ingredients of honey‐processed Astragalus by serum pharmacochemistry integrated with multivariate statistical analysis by Huang, Jing, Rui, Wen, Wu, Jiacai, Ye, Mingzhu, Huang, Li, Chen, Hongyuan

“…Honey‐processed Astragalus is a widely used traditional Chinese medicine that has a better effect on reinforcing “Qi” (vital energy) than the raw one. A…”
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Knockdown of NIR Suppresses Breast Cancer Cell Proliferation via Promoting FOXO3 by Chen, Bolin, Dong, Chengcheng, Wang, Fang, Wu, Jiacai

“…Novel inhibitor of histone acetyltransferase repressor (NIR), a corepressor with a novel inhibitor of histone acetyltransferase (INHAT) activity, has been…”
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Rapid analysis and identification of dianthrone glycosides in Polygoni Multiflori Caulis based on enrichment of macroporous absorbent resin and UPLC‐Q‐TOF‐MS/MS by Bo, Rui, Wu, Jian, Wu, Jiacai, Bai, Lisha, Ye, Mingzhu, Huang, Li, Chen, Hongyuan, Rui, Wen

“…Introduction Polygoni Multiflori Caulis (PMC) has been used as a traditional Chinese medicine for a long time in China. However, hepatotoxic events of PMC have…”
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Estrogen receptor α and aryl hydrocarbon receptor independent growth inhibitory effects of aminoflavone in breast cancer cells by Brinkman, Ashley M, Wu, Jiacai, Ersland, Karen, Xu, Wei

“…Numerous studies have implicated the aryl hydrocarbon receptor (AhR) as a potential therapeutic target for several human diseases, including estrogen receptor…”
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A PEG-lipid-free COVID-19 mRNA vaccine triggers robust immune responses in mice by Li, Min, Huang, Yixuan, Wu, Jiacai, Li, Sanpeng, Mei, Miao, Chen, Haixia, Wang, Ning, Wu, Weigang, Zhou, Boping, Tan, Xu, Li, Bin

“…COVID-19 mRNA vaccines represent a completely new category of vaccines and play a crucial role in controlling the COVID-19 pandemic. In this study, we have…”
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