Search Results - "Wu, Jennifer D"

Targeting CD73 to augment cancer immunotherapy by Roh, Meejeon, Wainwright, Derek A, Wu, Jennifer D, Wan, Yong, Zhang, Bin

“…•CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune cells.•CD73 has been hijacked by TME to promote tumor growth and…”
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Preoperative anxiety and implications on postoperative recovery: what can we do to change our history by Stamenkovic, Dusica M, Rancic, Nemanja K, Latas, Milan B, Neskovic, Vojislava, Rondovic, Goran M, Wu, Jennifer D, Cattano, Davide

“…Preoperative anxiety can influence the intensity of postoperative pain and anesthesia and analgesia requirement. In certain types of surgery, anxiety may even…”
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Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies by Zhai, Lijie, Bell, April, Ladomersky, Erik, Lauing, Kristen L, Bollu, Lakshmi, Sosman, Jeffrey A, Zhang, Bin, Wu, Jennifer D, Miller, Stephen D, Meeks, Joshua J, Lukas, Rimas V, Wyatt, Eugene, Doglio, Lynn, Schiltz, Gary E, McCusker, Robert H, Wainwright, Derek A

“…Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines…”
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Past, Current, and Future of Immunotherapies for Prostate Cancer by Boettcher, Adeline N, Usman, Ahmed, Morgans, Alicia, VanderWeele, David J, Sosman, Jeffrey, Wu, Jennifer D

“…Prostate cancer (PCa) is the most common cancer in men, and the second leading cause of cancer related death in men in Western countries. The standard therapy…”
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Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes by Weiner, Adam B., Vidotto, Thiago, Liu, Yang, Mendes, Adrianna A., Salles, Daniela C., Faisal, Farzana A., Murali, Sanjana, McFarlane, Matthew, Imada, Eddie L., Zhao, Xin, Li, Ziwen, Davicioni, Elai, Marchionni, Luigi, Chinnaiyan, Arul M., Freedland, Stephen J., Spratt, Daniel E., Wu, Jennifer D., Lotan, Tamara L., Schaeffer, Edward M.

“…Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no…”
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Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds by Kievit, Forrest M, Florczyk, Stephen J, Leung, Matthew C, Wang, Kui, Wu, Jennifer D, Silber, John R, Ellenbogen, Richard G, Lee, Jerry S.H, Zhang, Miqin

“…Abstract Emerging evidence implicates cancer stem cells (CSCs) as primary determinants of the clinical behavior of human cancers, representing an ideal target…”
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Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis by Liu, Gang, Lu, Shengjun, Wang, Xuanjun, Page, Stephanie T, Higano, Celestia S, Plymate, Stephen R, Greenberg, Norman M, Sun, Shaoli, Li, Zihai, Wu, Jennifer D

“…The activating receptor NK cell group 2 member D (NKG2D) mediates antitumor immunity in experimental animal models. However, whether NKG2D ligands contribute…”
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The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma by Ladomersky, Erik, Scholtens, Denise M, Kocherginsky, Masha, Hibler, Elizabeth A, Bartom, Elizabeth T, Otto-Meyer, Sebastian, Zhai, Lijie, Lauing, Kristen L, Choi, Jaehyuk, Sosman, Jeffrey A, Wu, Jennifer D, Zhang, Bin, Lukas, Rimas V, Wainwright, Derek A

“…Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is associated with a median overall survival (mOS) of 16-21 months. Our previous…”
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The expression profile and clinic significance of the SIX family in non-small cell lung cancer by Liu, Qian, Li, Anping, Tian, Yijun, Liu, Yu, Li, Tengfei, Zhang, Cuntai, Wu, Jennifer D, Han, Xinwei, Wu, Kongming

“…The SIX family homeobox genes have been demonstrated to be involved in the tumor initiation and progression, but their clinicopathological features and…”
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Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases by Liu, Gang, Atteridge, Catherine L, Wang, Xuanjun, Lundgren, Ashley D, Wu, Jennifer D

“…Abstract Engagement of tumor cell surface MHC class I chain-related molecule A (MICA) to NKG2D stimulates NK and T cell antitumor immunity. Shedding of MICA by…”
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Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging by Muñoz, Denise P, Yannone, Steven M, Daemen, Anneleen, Sun, Yu, Vakar-Lopez, Funda, Kawahara, Misako, Freund, Adam M, Rodier, Francis, Wu, Jennifer D, Desprez, Pierre-Yves, Raulet, David H, Nelson, Peter S, van 't Veer, Laura J, Campisi, Judith, Coppé, Jean-Philippe

“…Cellular senescence is a tumor suppressive mechanism that can paradoxically contribute to aging pathologies. Despite evidence of immune clearance in mouse…”
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Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy by Basher, Fahmin, Dhar, Payal, Wang, Xin, Wainwright, Derek A, Zhang, Bin, Sosman, Jeffrey, Ji, Zhe, Wu, Jennifer D

“…Melanoma patients who have detectable serum soluble NKG2D ligands either at the baseline or post-treatment of PD1/PDL1 blockade exhibit poor overall survival…”
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NKG2D and its ligands in cancer by Dhar, Payal, Wu, Jennifer D

“…•NKG2D pathway is significant for both innate and adoptive tumor immunity.•Soluble and membrane-bound NKG2D ligands confer opposite role in tumor…”
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Interaction of IGF signaling and the androgen receptor in prostate cancer progression by Wu, Jennifer D., Haugk, Kathy, Woodke, Libby, Nelson, Peter, Coleman, Ilsa, Plymate, Stephen R.

“…The insulin‐like growth factor type I receptor (IGF‐IR) has been suggested to play an important role in prostate cancer progression and possibly in the…”
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Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC + tumors respond to PD1/PD-L1 blockade therapy by Zhang, Jinyu, Larrocha, Pablo Saenz-Lopez, Zhang, Bin, Wainwright, Derek, Dhar, Payal, Wu, Jennifer D

“…Insufficient co-stimulation accounts for a great deal of the suboptimal activation of cytotoxic CD8 T cells (CTLs) and presumably unsatisfactory clinical…”
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Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer by Wu, Jennifer D, Higgins, Lily M, Steinle, Alexander, Cosman, David, Haugk, Kathy, Plymate, Stephen R

“…The MHC class I chain-related molecules (MICs) have previously been shown to be induced on most epithelial tumor cells. Engagement of MIC by the activating…”
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Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles by Blaschke, Calvin R K, Hartig, Jordan P, Grimsley, Grace, Liu, Liping, Semmes, O John, Wu, Jennifer D, Ippolito, Joseph E, Hughes-Halbert, Chanita, Nyalwidhe, Julius O, Drake, Richard R

“…Expressed prostatic secretions (EPS), also called post digital rectal exam urines, are proximal fluids of the prostate that are widely used for diagnostic and…”
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3D Porous Chitosan-Alginate Scaffolds: A New Matrix for Studying Prostate Cancer Cell-Lymphocyte Interactions In Vitro by Florczyk, Stephen J., Liu, Gang, Kievit, Forrest M., Lewis, Allison M., Wu, Jennifer D., Zhang, Miqin

“…The treatment of castration‐resistant prostate cancer (CRPC) remains palliative. Immunotherapy offers a potentially effective therapy for CRPC; however, its…”
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National Origin Identity and Descriptive Representativeness: Understanding Preferences for Asian Candidates and Representation by Wu, Jennifer D

“…Abstract This paper examines how an Asian candidate’s national origin background affects their perceived ability to represent different constituents. Would…”
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The Human Soluble NKG2D Ligand Differentially Impacts Tumorigenicity and Progression in Temporal and Model-Dependent Modes by Serritella, Anthony V, Saenz-Lopez Larrocha, Pablo, Dhar, Payal, Liu, Sizhe, Medd, Milan M, Jia, Shengxian, Cao, Qi, Wu, Jennifer D

“…NKG2D is an activating receptor expressed by all human NK cells and CD8 T cells. Harnessing the NKG2D/NKG2D ligand axis has emerged as a viable avenue for…”
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