Search Results - "Wu, James M."

Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1 by Feldman, Richard I., Wu, James M., Polokoff, Mark A., Kochanny, Monica J., Dinter, Harald, Zhu, Daguang, Biroc, Sandra L., Alicke, Bruno, Bryant, Judi, Yuan, Shendong, Buckman, Brad O., Lentz, Dao, Ferrer, Mike, Whitlow, Marc, Adler, Marc, Finster, Silke, Chang, Zheng, Arnaiz, Damian O.

“…The phosphoinositide 3-kinase/3-phosphoinositide-dependent kinase 1 (PDK1)/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumor…”
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Potent Triazolothione Inhibitor of Heat-Shock Protein-90 by Feldman, Richard I, Mintzer, Bob, Zhu, Daguang, Wu, James M, Biroc, Sandra L, Yuan, Shendong, Emayan, Kumar, Chang, Zheng, Chen, Deborah, Arnaiz, Damian O, Bryant, Judi, Ge, Xue Snow, Whitlow, Marc, Adler, Marc, Polokoff, Mark A, Li, Wei-Wei, Ferrer, Mike, Sato, Takashi, Gu, Jian-Ming, Shen, Jun, Tseng, Jih-Lie, Dinter, Harald, Buckman, Brad

“…Heat-shock protein-90 is an attractive target for anticancer drugs, as heat-shock protein-90 blockers such as the ansamycin…”
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Hepatocyte clearance and pharmacokinetics of recombinant factor IX glycosylation variants by Blasko, Eric, Brooks, Alan R., Ho, Elena, Wu, James M., Zhao, Xiao-Yan, Subramanyam, Babu

“…•Our in vitro hepatocyte clearance assay identified rapidly cleared Factor IX protein variants.•Variants that were rapidly cleared in vivo were also cleared…”
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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity by Islam, Imadul, Bryant, Judi, Chou, Yuo-Ling, Kochanny, Monica J., Lee, Wheeseong, Phillips, Gary B., Yu, Hongyi, Adler, Marc, Whitlow, Marc, Ho, Elena, Lentz, Dao, Polokoff, Mark A., Subramanyam, Babu, Wu, James M., Zhu, Daguang, Feldman, Richard I., Arnaiz, Damian O.

“…Optimization of 1 afforded 4i ( BX-517), a potent and selective inhibitor of PDK1. HTS screening identified 1 with micromolar inhibitory activity against PDK1…”
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In situ hybridization for gastrin‐releasing peptide receptor (GRP receptor) expression in prostatic carcinoma by Bartholdi, Marty F., Wu, James M., Pu, Haifeng, Troncoso, Patricia, Eden, Peter A., Feldman, Richard I.

“…Bombesin‐like peptides (BLPs), which have been implicated in the regulation of growth of prostatic carcinoma cells, are a product of neuroendocrine cells…”
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Parathyroidectomy for asymptomatic primary hyperparathyroidism: A revised cost-effectiveness analysis incorporating fracture risk reduction by Zanocco, Kyle A., MD, MS, Wu, James X., MD, Yeh, Michael W., MD

“…Background Recent data demonstrate decreased fracture risk after operation for asymptomatic primary hyperparathyroidism. We performed a revised…”
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Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management by Talan, David A., MD, Saltzman, Darin J., MD, PhD, Mower, William R., MD, PhD, Krishnadasan, Anusha, PhD, Jude, Cecilia M., MD, Amii, Ricky, MD, DeUgarte, Daniel A., MD, MS, Wu, James X., MD, Pathmarajah, Kavitha, MPH, Morim, Ashkan, MPH, Moran, Gregory J., MD

“…Study objective Randomized trials suggest that nonoperative treatment of uncomplicated appendicitis with antibiotics-first is safe. No trial has evaluated…”
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Wear Rates of XLPE Nearly 50% Lower Than Previously Thought After Adjusting for Initial Creep by Amir Khoshbin, MD, MSc, FRCSC, James Wu, MD, Sarah Ward, MD, FRCSC, Luana T. Melo, PhD, Emil H. Schemitsch, MD, FRCSC, PhD, James P. Waddell, MD, FRCSC, Amit Atrey, MD, MSc, FRCS(Tr&Orth)

“…Background:. The ideal bearing combination for total hip arthroplasty (THA) remains debatable. Highly cross-linked polyethylene (XLPE) is widely used, but…”
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Effect of malignancy rates on cost-effectiveness of routine gene expression classifier testing for indeterminate thyroid nodules by Wu, James X., MD, Lam, Raymond, Levin, Mary, Rao, Jianyu, MD, Sullivan, Peggy S., MD, Yeh, Michael W., MD

“…Background The value of gene expression classifier (GEC) testing for cytologically indeterminate thyroid nodules lies in its negative predictive value, which…”
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Molecular Cloning for the Bombesin/Gastrin-Releasing Peptide Receptor From Swiss 3T3 Cells by Battey, James F., Way, James M., Corjay, Martha H., Shapira, Hagit, Kusano, Kiyoshi, Harkins, Richard, Wu, James M., Slattery, Timothy, Mann, Elaina, Feldman, Richard I.

“…The mammalian bombesin-like peptides gastrin-releasing peptide (GRP) and neuromedin B regulate numerous and varied cell physiologic processes in various cell…”
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Cost effectiveness of nonoperative management versus laparoscopic appendectomy for acute uncomplicated appendicitis by Wu, James X., MD, Dawes, Aaron J., MD, Sacks, Greg D., MD, MPH, Brunicardi, F. Charles, MD, Keeler, Emmett B., PhD

“…Background Appendectomy remains the gold standard in the treatment of acute, uncomplicated appendicitis in the United States. Nonetheless, there is growing…”
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The use of newer technologies by New Zealand dentists by Tay, Kelvin I-P, Wu, James M-Y, Yew, Michael S-S, Thomson, W Murray

“…To determine the prevalence and use of newer technologies among New Zealand general dental practitioners (GDPs). Cross-sectional survey of a random sample of…”
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Management of small bowel obstruction and systematic review of treatment without nasogastric tube decompression by Klingbeil, Kyle D., Wu, James X., Osuna-Garcia, Antonia, Livingston, Edward H.

“…Small bowel obstruction (SBO) is common and its management has evolved in recent years. The literature describing adhesive small bowel obstruction (aSBO)…”
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Septal myectomy in obstructive hypertrophic cardiomyopathy high risk patients by Geist, Heather, Wu, James K., MD, Martinez, Matthew W., MD

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Outcomes of Adult Venovenous Extracorporeal Membrane Oxygenation Patients without Anticoagulation: A Retrospective Review at a Tertiary Level Referral Center by Juthani, Biren, DO, Hilaire, Cameron ST, Auvil, Bryan, Mattiola, Rosalie, Pechulis, Rita, MD, Wu, James K., MD

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Cost Modeling for Management Strategies of Uncomplicated Gastroschisis by Wu, James X., MD, Lee, Steven L., MD, DeUgarte, Daniel A., MD

“…Abstract Introduction Compared to operative fascial closure, non-operative flap/skin-closure repair for gastroschisis has several potential advantages:…”
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Asymptomatic Primary Hyperparathyroidism by Wu, James X., MD, Yeh, Michael W., MD

“…Primary hyperparathyroidism (PHPT) is a common disease, with a prevalence as high as 1 in 400 women and 1 in 1000 men, and most are asymptomatic. Patients with…”
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Introduction by Wu, James, MD, PhD

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Rectal Prolapse: A Historical Perspective by Wu, James S., MD, PhD

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Patient Willingness to Participate in a US Randomized Controlled Trial for Nonoperative Management of Uncomplicated Appendicitis by Yan, Huan, Lee, Steven L., MD, FACS, Krishnadasan, Anusha, PhD, Brunicardi, F. Charles, MD, FACS, DeUgarte, Daniel A., MD, FACS, Katkhouda, Namir, MD, FACS, McPheeters, Rick, DO, Salem, Roee, Wu, James X., MD, Talan, David A., MD

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