Search Results - "Wu, Indira"

Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures by Wu, Indira, Arnold, Frances H.

“…Thermostability is an important feature in industrial enzymes: it increases biocatalyst lifetime and enables reactions at higher temperatures, where faster…”
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family of thermostable fungal cellulases created by structure-guided recombination by Heinzelman, Pete, Snow, Christopher D, Wu, Indira, Nguyen, Catherine, Villalobos, Alan, Govindarajan, Sridhar, Minshull, Jeremy, Arnold, Frances H

“…SCHEMA structure-guided recombination of 3 fungal class II cellobiohydrolases (CBH II cellulases) has yielded a collection of highly thermostable CBH II…”
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Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer by Liu, Silvia, Wu, Indira, Yu, Yan-Ping, Balamotis, Michael, Ren, Baoguo, Ben Yehezkel, Tuval, Luo, Jian-Hua

“…The characterization of human gene expression is limited by short read lengths, high error rates and large input requirements. Here, we used a synthetic long…”
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Haplotyping germline and cancer genomes with high-throughput linked-read sequencing by Zheng, Grace X Y, Lau, Billy T, Schnall-Levin, Michael, Jarosz, Mirna, Bell, John M, Hindson, Christopher M, Kyriazopoulou-Panagiotopoulou, Sofia, Masquelier, Donald A, Merrill, Landon, Terry, Jessica M, Mudivarti, Patrice A, Wyatt, Paul W, Bharadwaj, Rajiv, Makarewicz, Anthony J, Li, Yuan, Belgrader, Phillip, Price, Andrew D, Lowe, Adam J, Marks, Patrick, Vurens, Gerard M, Hardenbol, Paul, Montesclaros, Luz, Luo, Melissa, Greenfield, Lawrence, Wong, Alexander, Birch, David E, Short, Steven W, Bjornson, Keith P, Patel, Pranav, Hopmans, Erik S, Wood, Christina, Kaur, Sukhvinder, Lockwood, Glenn K, Stafford, David, Delaney, Joshua P, Wu, Indira, Ordonez, Heather S, Grimes, Susan M, Greer, Stephanie, Lee, Josephine Y, Belhocine, Kamila, Giorda, Kristina M, Heaton, William H, McDermott, Geoffrey P, Bent, Zachary W, Meschi, Francesca, Kondov, Nikola O, Wilson, Ryan, Bernate, Jorge A, Gauby, Shawn, Kindwall, Alex, Bermejo, Clara, Fehr, Adrian N, Chan, Adrian, Saxonov, Serge, Ness, Kevin D, Hindson, Benjamin J, Ji, Hanlee P

“…A microfluidics approach that links short sequence reads enables haplotype construction and complex variation identification from tiny amounts of input DNA…”
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Resolving the full spectrum of human genome variation using Linked-Reads by Marks, Patrick, Garcia, Sarah, Barrio, Alvaro Martinez, Belhocine, Kamila, Bernate, Jorge, Bharadwaj, Rajiv, Bjornson, Keith, Catalanotti, Claudia, Delaney, Josh, Fehr, Adrian, Fiddes, Ian T, Galvin, Brendan, Heaton, Haynes, Herschleb, Jill, Hindson, Christopher, Holt, Esty, Jabara, Cassandra B, Jett, Susanna, Keivanfar, Nikka, Kyriazopoulou-Panagiotopoulou, Sofia, Lek, Monkol, Lin, Bill, Lowe, Adam, Mahamdallie, Shazia, Maheshwari, Shamoni, Makarewicz, Tony, Marshall, Jamie, Meschi, Francesca, O'Keefe, Christopher J, Ordonez, Heather, Patel, Pranav, Price, Andrew, Royall, Ariel, Ruark, Elise, Seal, Sheila, Schnall-Levin, Michael, Shah, Preyas, Stafford, David, Williams, Stephen, Wu, Indira, Xu, Andrew Wei, Rahman, Nazneen, MacArthur, Daniel, Church, Deanna M

“…Large-scale population analyses coupled with advances in technology have demonstrated that the human genome is more diverse than originally thought. To date,…”
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Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways by Hu, Xiaoyu, Chung, Allen Y., Wu, Indira, Foldi, Julia, Chen, Janice, Ji, Jong Dae, Tateya, Tomoko, Kang, Young Jun, Han, Jiahuai, Gessler, Manfred, Kageyama, Ryoichiro, Ivashkiv, Lionel B.

“…Toll-like receptor (TLR) responses are regulated to avoid toxicity and achieve coordinated responses appropriate for the cell environment. We found that Notch…”
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Abstract 3128: Using Kmerizer, a germline and somatic genotyper for immune associated complex alleles in GuardantINFINITY, for immunotherapy response prediction using cfDNA by Gnerre, Sante, Zhao, Jun, Bubie, Adrian, Kim, Yvonne, Ma, Dustin, Wu, Indira, Losic, Bojan, Jiang, Tingting, Chuang, Han-Yu

“…Abstract Background: HLA germline genotypes and somatic mutations show great promise as emerging biomarkers for immune checkpoint inhibitors (ICIs) and…”
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Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases by Wu, Indira, Heel, Thomas, Arnold, Frances H.

“…Numerous protein engineering studies have focused on increasing the thermostability of fungal cellulases to improve production of fuels and chemicals from…”
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Abstract 1220: Accurately genotyping HLA and KIR alleles using cfDNA assay and k-mer based algorithm for immunotherapy by Gnerre, Sante, Tsui, Brian Yik Tak, Jiang, Tingting, Kim, Yvonne, Ma, Dustin, Wu, Indira, Nagy, Rebecca, Chuang, Han-Yu

“…Abstract Background: HLA and KIR genotypes show great promise as emerging biomarkers for immune checkpoint inhibitors (ICIs) and understanding patient…”
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Abstract 3123: A method for quantifying circulating tumor DNA level and molecular response using methylome sequencing by Chen, Sai, Quinn, Katie, Lee, Che-Yu, Zhao, Jun, Chang, Kyle, Jiang, Tingting, Zhang, Shile, Espenschied, Carin, Wienke, Sara, Rich, Thereasa, Wu, Indira, Kim, Yvonne, Liu, Xianxian, Alla, Nageswara, Ma, Dustin, Tran, Giao, Chuang, Han-Yu

“…Abstract Background: Circulating tumor DNA (ctDNA) level and the change in level at a subsequent time point (e.g. on-treatment change from baseline or…”
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Abstract 3758: Accurate epigenomic estimates of circulating tumor fraction in large-scale clinical data by Greenwald, William W., He, Yupeng, Chen, Sai, Jiang, Tingting, Valouev, Anton, Min, Jun, Barbacioru, Catalin, Gaile, Daniel P., Ma, Dustin, Kim, Yvonne, Tran, Giao, Wu, Indira, Jaimovich, Ariel, Raymond, Victoria, Nagy, Rebecca J., Chuang, Han-Yu

“…Abstract Background: Liquid biopsy offers a rapid and non-invasive alternative to tissue biopsy for identifying biomarkers. More recently, its application has…”
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Abstract 6601: Analytical validation of a robust integrated genomic and epigenomic liquid biopsy for biomarker discovery, therapy selection, and response monitoring by Jiang, Tingting, Wu, Indira, Kim, Yvonne, Alla, Nageswara, Tran, Giao, Ma, Dustin, Shah, Forum, Zhao, Jun, Chen, Sai, Gnerre, Sante, Hazar, Melis, Wang, Hao, Barbacioru, Catalin, Ryall, Karen, Jambusaria, Ankit, Chakravarthy, Anupam, Zunino, Anthony, Pham, Theresa, Ghadiri, Farsheed, Diehl, Evan, Morck, Benjamin, Sanchez, Arancha, Dayan, Rochelle, Liu, XianXian, Werbin, Jeffrey, Lai, Jill, Kennedy, Brett, Eppler, Ross, Odegaard, Justin, Chuang, Han-Yu, Eltoukhy, Helmy

“…Abstract Background: Despite its revolutionary impact, cancer genomics alone provides little information on tumor phenotype or functional state, which are…”
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Engineering Thermostable Fungal Cellobiohydrolases by Wu, Indira

“…Meeting the world's growing energy demands while protecting our fragile environment is a challenging issue. Second generation biofuels are liquid fuels like…”
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Haplotyping germline and cancer genomes using high-throughput linked-read sequencing by Zheng, Grace X.Y., Lau, Billy T., Schnall-Levin, Michael, Jarosz, Mirna, Bell, John M., Hindson, Christopher M., Kyriazopoulou-Panagiotopoulou, Sofia, Masquelier, Donald A., Merrill, Landon, Terry, Jessica M., Mudivarti, Patrice A., Wyatt, Paul W., Bharadwaj, Rajiv, Makarewicz, Anthony J., Li, Yuan, Belgrader, Phillip, Price, Andrew D., Lowe, Adam J., Marks, Patrick, Vurens, Gerard M., Hardenbol, Paul, Montesclaros, Luz, Luo, Melissa, Greenfield, Lawrence, Wong, Alexander, Birch, David E., Short, Steven W., Bjornson, Keith P., Patel, Pranav, Hopmans, Erik S., Wood, Christina, Kaur, Sukhvinder, Lockwood, Glenn K., Stafford, David, Delaney, Joshua P., Wu, Indira, Ordonez, Heather S., Grimes, Susan M., Greer, Stephanie, Lee, Josephine Y., Belhocine, Kamila, Giorda, Kristina M., Heaton, William H., McDermott, Geoffrey P., Bent, Zachary W., Meschi, Francesca, Kondov, Nikola O., Wilson, Ryan, Bernate, Jorge A., Gauby, Shawn, Kindwall, Alex, Bermejo, Clara, Fehr, Adrian N., Chan, Adrian, Saxonov, Serge, Ness, Kevin D., Hindson, Benjamin J., Ji, Hanlee P.

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Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-[gamma] Pathways by Hu, Xiaoyu, Chung, Allen Y, Wu, Indira, Foldi, Julia, Chen, Janice, Ji, Jong Dae, Tateya, Tomoko, Kang, Young Jun, Han, Jiahuai, Gessler, Manfred, Kageyama, Ryoichiro, Ivashkiv, Lionel B

“…Toll-like receptor (TLR) responses are regulated to avoid toxicity and achieve coordinated responses appropriate for the cell environment. We found that Notch…”
Get full text

Engineering Thermostable Fungal Cellobiohydrolases by Wu, Indira

“…Meeting the world's growing energy demands while protecting our fragile environment is a challenging issue. Second generation biofuels are liquid fuels like…”
Get full text