Search Results - "Wu, Glendon S"

Inefficient V(D)J recombination underlies monogenic T cell receptor β expression by Wu, Glendon S., Bassing, Craig H.

“…The assembly of T cell receptor (TCR) and immunoglobulin (Ig) genes by V(D)J recombination generates the antigen receptor (AgR) diversity that is vital for…”
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Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation by Carr, Erikka L, Kelman, Alina, Wu, Glendon S, Gopaul, Ravindra, Senkevitch, Emilee, Aghvanyan, Anahit, Turay, Achmed M, Frauwirth, Kenneth A

“…Activation of a naive T cell is a highly energetic event, which requires a substantial increase in nutrient metabolism. Upon stimulation, T cells increase in…”
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Neuroimmune Interactions in Peripheral Organs by Klein Wolterink, Roel G.J, Wu, Glendon S, Chiu, Isaac M, Veiga-Fernandes, Henrique

“…Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was…”
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Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection by Yang, Daping, Jacobson, Amanda, Meerschaert, Kimberly A., Sifakis, Joseph Joy, Wu, Meng, Chen, Xi, Yang, Tiandi, Zhou, Youlian, Anekal, Praju Vikas, Rucker, Rachel A., Sharma, Deepika, Sontheimer-Phelps, Alexandra, Wu, Glendon S., Deng, Liwen, Anderson, Michael D., Choi, Samantha, Neel, Dylan, Lee, Nicole, Kasper, Dennis L., Jabri, Bana, Huh, Jun R., Johansson, Malin, Thiagarajah, Jay R., Riesenfeld, Samantha J., Chiu, Isaac M.

“…Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which sensory neurons communicate with epithelial cells to mediate gut…”
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Poor-Quality Vβ Recombination Signal Sequences and the DNA Damage Response ATM Kinase Collaborate to Establish TCRβ Gene Repertoire and Allelic Exclusion by Wu, Glendon S, Culberson, Erica J, Allyn, Brittney M, Bassing, Craig H

“…The monoallelic expression (allelic exclusion) of diverse lymphocyte Ag receptor genes enables specific immune responses. Allelic exclusion is achieved by…”
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Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion by Wu, Glendon S, Yang-Iott, Katherine S, Klink, Morgann A, Hayer, Katharina E, Lee, Kyutae D, Bassing, Craig H

“…The monoallelic expression of antigen receptor (AgR) genes, called allelic exclusion, is fundamental for highly specific immune responses to pathogens. This…”
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Flip the switch: BTG2–PRMT1 protein complexes antagonize pre-B-cell proliferation to promote B-cell development by Wu, Glendon S, Bassing, Craig H

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The ESCRT protein CHMP5 escorts αβ T cells through positive selection by Wu, Glendon S, Bassing, Craig H

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Monoallelic and monogenic Tcrb assembly enforced by Vβ recombination signal sequences and physiological roles for Tcrb repertoire and allelic exclusion by Wu, Glendon S, Bassing, Craig

“…Abstract Monoallelic expression of antigen receptor (AgR) genes is assumed to be critical for the proper selection and function of T and B lymphocytes. V(D)J…”
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Vβ recombination signal sequences enforce TCRβ allelic exclusion by Wu, Glendon S., Yang-Iott, Katherine, Bassing, Craig

“…Abstract The assembly of antigen receptor (AgR) genes via RAG1/RAG2 (RAG) mediated recombination of variable (V), diversity (D), and joining (J) gene segments…”
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Recombination signal sequences shape antigen receptor repertoires and enforce allelic exclusion by Wu, Glendon S, Yang-Iott, Katherine S, Bassing, Craig H

“…Abstract Antigen receptor loci are arrays of variable (V), diversity (D), and joining (J) gene segments that the RAG endonuclease assembles into complete AgR…”
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Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK During T Lymphocyte Activation1 by Carr, Erikka L., Kelman, Alina, Wu, Glendon S., Gopaul, Ravindra, Senkevitch, Emilee, Aghvanyan, Anahit, Turay, Achmed M., Frauwirth, Kenneth A.

“…Activation of a naïve T cell is a highly energetic event, which requires a substantial increase in nutrient metabolism. Upon stimulation, T cells increase in…”
Get full text