Search Results - "Wu, Chutse"

IL-6 secreted from senescent mesenchymal stem cells promotes proliferation and migration of breast cancer cells by Di, Guo-Hu, Liu, Yang, Lu, Ying, Liu, Jin, Wu, Chutse, Duan, Hai-Feng

“…Human mesenchymal stem cells (hMSCs) are currently investigated for a variety of therapeutic applications. However, MSCs isolated from primary tissue cannot…”
Get full text

Recombinant neorudin and its active metabolite hirudin: the fate in vivo of a novel anticoagulant drug by Li, Qiang, Liu, Yubin, Ren, Boyuan, Jin, Jiayan, Zhang, Lin, Wu, ChuTse, Jin, JiDe

“…Thrombosis, a prevalent condition, can provoke severe health issues like acute coronary syndrome (ACS), deep vein thrombosis (DVT), and pulmonary embolism…”
Get full text

Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury by Yang, Yang, Zhai, Huali, Wan, Yue, Wang, Xiaofang, Chen, Hui, Dong, Lihou, Liu, Taoyun, Dou, Guifang, Wu, Chutse, Yu, Miao

“…Acute liver injury shares a common feature of hepatocytes death, immune system disorders, and cellular stress. Hepassocin (HPS) is a hepatokine that has…”
Get full text

miR-486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON by Sun, Huiyan, Cui, Chunping, Xiao, Fengjun, Wang, Hua, Xu, Jun, Shi, Xuefeng, Yang, Yuefeng, Zhang, Qunwei, Zheng, Xiaofei, Yang, Xiaoming, Wu, Chutse, Wang, Lisheng

“…Aim miRNA‐486 (miR‐486) was first identified from the human fetal liver cDNA library and considered to be associated with hepatocellular carcinoma (HCC)…”
Get full text

Study on the activity of recombinant mutant tissue-type plasminogen activator fused with the C-terminal fragment of hirudin by Ren, Keyun, Gong, Hao, Hu, Lingli, He, Kun, Yu, Aiping, Hu, Shangjie, Liang, Shuheng, Zhou, Changmao, Wu, Chutse

“…In the present study, bifunctional fusion proteins were designed by fusing the kringle 2 and protease domains of tissue-type plasminogen activator (tPA) to the…”
Get full text

Short-term memory of danger signals or environmental stimuli in mesenchymal stem cells： implications for therapeutic potential by Liu, Guang-Yang, Liu, Yang, Lu, Ying, Qin, Ya-Ru, Di, Guo-Hu, Lei, Yong-Hong, Liu, Hu-Xian, Li, Yan-Qi, Wu, Chutse, Hu, Xian-Wen, Duan, Hai-Feng

“…Mesenchymal stem/stromal cells （MSCs） possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype,…”
Get full text

Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice by Chen, Jinlong, Ma, Mengmeng, Lu, Yanwei, Wang, Lisheng, Wu, Chutse, Duan, Haifeng

“…We isolated several stilbene compounds including rhaponticin (3',5-dihydroxy-4'-methoxystilbene 3- O-beta- D-glucopyranoside) from extracts of rhubarb…”
Get more information

Acetylation of sphingosine kinase 1 regulates cell growth and cell-cycle progression by Yu, Hongyang, Shao, Yong, Gao, Lihua, Zhang, Liancheng, Guo, Kanghe, Wu, Chutse, Hu, Xianwen, Duan, Haifeng

“…► SPK1 protein contains a conserved acetylation motif (the GK motif). ► Lysine acetylation is an important regulatory manner of SPK1 protein. ► SPK1 is…”
Get full text

TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation by Zhang, Lian-Cheng, Shao, Yong, Gao, Li-Hua, Liu, Jin, Xi, Yong-Yi, Xu, Yin, Wu, Chutse, Chen, Wei, Chen, Hui-Peng, Wang, You-Liang, Duan, Hai-Feng, Hu, Xian-Wen

“…TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin…”
Get full text

Construction and functional evaluation of hirudin derivatives with low bleeding risk by Zhang, Chuanling, Yu, Aiping, Yuan, Bin, Dong, Chunna, Yu, Hongyang, Wang, Lisheng, Wu, Chutse

“…The purpose of this study was to design and evaluate hirudin (HIR) derivatives with low bleeding risk. In these derivatives, the factor (F) XIa, FXa, and…”
Get more information

Keratinocyte Growth Factor (KGF) Gene Therapy Mediated by an Attenuated Form of Salmonella typhimurium Ameliorates Radiation Induced Pulmonary Injury in Rats by Liu, Chun-Jie, Ha, Xiao-Qin, Jiang, Jun-Jun, Lv, Tong-De, Wu, Chutse

“…The aim of this study is to investigate the effect of KGF (Keratinocyte growth factor) gene therapy mediated by the attenuated Salmonella typhimurium Ty21a on…”
Get full text

A fusion protein with improved thrombolytic effect and low bleeding risk by Wang, Xiudong, Zhang, Guangman, Wang, Lisheng, Zhang, Qinglin, Qin, Yide, Wu, Chutse, Yu, Aiping

“…To resolve the therapeutic dilemma between efficacy of thrombolysis and bleeding risk associated with the use of a combination of thrombolytic and…”
Get more information

Stimulation of the Mitogen-activated Protein Kinase Cascade and Tyrosine Phosphorylation of the Epidermal Growth Factor Receptor by Hepatopoietin by Li, Yong, Li, Ming, Xing, Guichun, Hu, Zhiyuan, Wang, Qingming, Dong, Chunna, Wei, Handong, Fan, Guocai, Chen, Jizhong, Yang, Xiaoming, Zhao, Shifu, Chen, Huipeng, Guan, Kunliang, Wu, Chutse, Zhang, Chenggang, He, Fuchu

“…Hepatopoietin (HPO) is a novel human hepatotrophic growth factor, which specifically stimulates proliferation of cultured primary hepatocytes in vitro and…”
Get full text

A novel AXL chimeric antigen receptor endows T cells with anti-tumor effects against triple negative breast cancers by Wei, Jing, Sun, Huiyan, Zhang, Aimei, Wu, Xuejie, Li, Yuxiang, Liu, Jiawei, Duan, Yanting, Xiao, Fengjun, Wang, Hua, Lv, Ming, Wang, Lisheng, Wu, Chutse

“…•AXL and Gas6 are highly expressed in cell lines and patient samples including TNBC.•AXL-CAR-T cells exhibit specific cytotoxicity to AXL-positive tumor…”
Get full text

Identification and Characterization of Receptor for Mammalian Hepatopoietin That Is Homologous to Yeast ERV1 by Wang, G, Yang, X, Zhang, Y, Wang, Q, Chen, H, Wei, H, Xing, G, Xie, L, Hu, Z, Zhang, C, Fang, D, Wu, C, He, F

“…Hepatopoietin (HPO) is a novel polypeptide mitogen specific for hepatocytes and hepatoma cell lines, which is derived from liver and supports its regeneration…”
Get full text

HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis by Yang, Yang, Liu, Xian, Chen, Hui, Wang, Pengjun, Yao, Songhui, Zhou, Bin, Yin, Ronghua, Li, Changyan, Wu, Chutse, Yang, Xiaoming, Yu, Miao

“…Hepassocin (HPS) is a hepatokine associated with metabolic regulation and development of non‐alcoholic steatohepatitis (NASH). However, previous reports on HPS…”
Get full text

Thrombolytic and anticoagulant effects of a recombinant staphylokinase-hirudin fusion protein by Ren, Keyun, Gong, Hao, Huang, Junjie, Liu, Yubin, Dong, Qiaoyan, He, Kun, Tian, Lvming, Zhang, Fan, Yu, Aiping, Wu, Chutse

“…A pure recombinant staphylokinase-hirudin fusion protein (SFH) was obtained by recombinant genetic engineering and purification techniques. The thrombolytic…”
Get full text

Structure and activity of an anti‐epidermal growth factor receptor antibody without galactose‐α‐1,3‐galactose residues by Ren, Keyun, Gong, Hao, Ma, Zheng, Tian, Lvming, Ye, Wei, Lv, Xingkai, Wu, Chutse

“…Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, which has been considered as one of the key targets for cancer therapy. However,…”
Get full text

An Oncolytic Adenovirus Encoding Decorin and Granulocyte Macrophage Colony Stimulating Factor Inhibits Tumor Growth in a Colorectal Tumor Model by Targeting Pro-Tumorigenic Signals and via Immune Activation by Liu, Zhao, Yang, Yuefeng, Zhang, Xiaoyan, Wang, Hao, Xu, Weidong, Wang, Hua, Xiao, Fengjun, Bai, Zhigang, Yao, Hongwei, Ma, Xuemei, Jin, Lan, Wu, Chutse, Seth, Prem, Zhang, Zhongtao, Wang, Lisheng

“…In advanced and metastatic stages of colorectal cancer (CRC), reduced sensitivity to conventional strategies is still a major obstacle to successful…”
Get more information

SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation by Zhang, Xiaoyan, Wang, Hao, Wang, Hua, Xiao, Fengjun, Seth, Prem, Xu, Weidong, Jia, Qinghua, Wu, Chutse, Yang, Yuefeng, Wang, Lisheng

“…In advanced prostate cancer, small ubiquitin-like modifier (SUMO)-specific cysteine protease 1 (SENP1) is up-regulated. However, the role of SENP1 in…”
Get full text