Search Results - "Wu, Chunyan"
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1
An adaptive excitation source for high-speed multiphoton microscopy
Published in Nature methods (01-02-2020)“…Optical imaging is important for understanding brain function. However, established methods with high spatiotemporal resolution are limited by the potential…”
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2
Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy
Published in International journal of molecular sciences (17-01-2023)“…Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined neurodevelopmental disorder. Over the past two decades, the prevalence of autism…”
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3
Three-photon imaging of mouse brain structure and function through the intact skull
Published in Nature methods (01-10-2018)“…Optical imaging through the intact mouse skull is challenging because of skull-induced aberrations and scattering. We found that three-photon excitation…”
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4
Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
Published in The Journal of experimental medicine (11-02-2013)“…Macroautophagy serves cellular housekeeping and metabolic functions through delivery of cytoplasmic constituents for lysosomal degradation. In addition, it may…”
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Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism
Published in Frontiers in immunology (11-12-2017)“…Interferons (IFNs), which were discovered a half century ago, are a group of secreted proteins that play key roles in innate immunity against viral infection…”
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6
Targeting HDACs for diffuse large B-cell lymphoma therapy
Published in Scientific reports (02-01-2024)“…Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well…”
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7
Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer
Published in Nature communications (05-05-2021)“…Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor microenvironment together determine disease progression, as well as…”
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8
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis
Published in The Journal of experimental medicine (04-11-2019)“…The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of…”
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9
Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt
Published in The Journal of nutritional biochemistry (01-02-2016)“…We have previously reported that astaxanthin (AX), a dietary carotenoid, directly interacts with peroxisome proliferator-activated receptors PPARα and PPARγ,…”
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10
Linear Laser Scanning Measurement Method Tracking by a Binocular Vision
Published in Sensors (Basel, Switzerland) (07-05-2022)“…The 3D scanning of a freeform structure relies on the laser probe and the localization system. The localization system, determining the effect of the point…”
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11
Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer
Published in Genome Biology (24-06-2020)“…Abstract Background Malignant transformation and progression of cancer are driven by the co-evolution of cancer cells and their dysregulated tumor…”
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12
Improved Vaccine against PRRSV: Current Progress and Future Perspective
Published in Frontiers in microbiology (28-08-2017)“…Porcine reproductive and respiratory syndrome virus (PRRSV), one of the most economically significant pathogens worldwide, has caused numerous outbreaks during…”
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13
Immortalization of chicken preadipocytes by retroviral transduction of chicken TERT and TR
Published in PloS one (09-05-2017)“…The chicken is an important agricultural animal and model for developmental biology, immunology and virology. Excess fat accumulation continues to be a serious…”
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14
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis
Published in The Journal of experimental medicine (03-05-2021)“…The role of the PYHIN family member absent in melanoma 2 (AIM2), another important inflammasome sensor, in EAE remains unclear. In this study, we found that…”
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15
Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis
Published in Genome Biology (27-07-2017)“…The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing spondylitis is an…”
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16
Determination of catechins and flavonol glycosides in Chinese tea varieties
Published in Food chemistry (01-05-2012)“…► A standardised HPLC–UV–MS method for tea analyses has been established. ► Pertinent phenolic compounds in Chinese teas have been identified and quantified. ►…”
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17
The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
Published in Nature communications (30-04-2018)“…The senescence-associated secretory phenotype (SASP) can be provoked by side effects of therapeutic agents, fueling advanced complications including cancer…”
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18
Developmental neurotoxic effects of bisphenol A and its derivatives in Drosophila melanogaster
Published in Ecotoxicology and environmental safety (15-07-2023)“…As a result of the ban on bisphenol A (BPA), a hormone disruptor with developmental neurotoxicity, several BPA derivatives (BPs) have been widely used in…”
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Metabonomics Research Progress on Liver Diseases
Published in Canadian journal of gastroenterology & hepatology (01-01-2017)“…Metabolomics as the new omics technique develops after genomics, transcriptomics, and proteomics and has rapid development at present. Liver diseases are…”
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20
Preliminary research on the identification system for anthracnose and powdery mildew of sandalwood leaf based on image processing
Published in PloS one (27-07-2017)“…This paper presents a survey on a system that uses digital image processing techniques to identify anthracnose and powdery mildew diseases of sandalwood from…”
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