Search Results - "Wu, Catherine J"

Dynamics and specificities of T cells in cancer immunotherapy by Oliveira, Giacomo, Wu, Catherine J.

“…Recent advances in cancer immunotherapy — ranging from immune-checkpoint blockade therapy to adoptive cellular therapy and vaccines — have revolutionized…”
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Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity by Rooney, Michael S., Shukla, Sachet A., Wu, Catherine J., Getz, Gad, Hacohen, Nir

“…How the genomic landscape of a tumor shapes and is shaped by anti-tumor immunity has not been systematically explored. Using large-scale genomic data sets of…”
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Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns by Tang, Alison D., Soulette, Cameron M., van Baren, Marijke J., Hart, Kevyn, Hrabeta-Robinson, Eva, Wu, Catherine J., Brooks, Angela N.

“…While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-length isoform changes may better elucidate the functional consequences…”
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SF3B1 mutations in chronic lymphocytic leukemia by Wan, Youzhong, Wu, Catherine J.

“…SF3B1 is a critical component of the splicing machinery, which catalyzes the removal of introns from precursor messenger RNA (mRNA). Next-generation sequencing…”
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Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction by Abelin, Jennifer G., Keskin, Derin B., Sarkizova, Siranush, Hartigan, Christina R., Zhang, Wandi, Sidney, John, Stevens, Jonathan, Lane, William, Zhang, Guang Lan, Eisenhaure, Thomas M., Clauser, Karl R., Hacohen, Nir, Rooney, Michael S., Carr, Steven A., Wu, Catherine J.

“…Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep…”
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Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia by Landau, Dan A., Carter, Scott L., Stojanov, Petar, McKenna, Aaron, Stevenson, Kristen, Lawrence, Michael S., Sougnez, Carrie, Stewart, Chip, Sivachenko, Andrey, Wang, Lili, Wan, Youzhong, Zhang, Wandi, Shukla, Sachet A., Vartanov, Alexander, Fernandes, Stacey M., Saksena, Gordon, Cibulskis, Kristian, Tesar, Bethany, Gabriel, Stacey, Hacohen, Nir, Meyerson, Matthew, Lander, Eric S., Neuberg, Donna, Brown, Jennifer R., Getz, Gad, Wu, Catherine J.

“…Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by…”
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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma by Van Allen, Eliezer M., Miao, Diana, Schilling, Bastian, Shukla, Sachet A., Blank, Christian, Zimmer, Lisa, Sucker, Antje, Hillen, Uwe, Foppen, Marnix H. Geukes, Goldinger, Simone M., Utikal, Jochen, Hassel, Jessica C., Weide, Benjamin, Kaehler, Katharina C., Loquai, Carmen, Mohr, Peter, Gutzmer, Ralf, Dummer, Reinhard, Gabriel, Stacey, Wu, Catherine J., Schadendorf, Dirk, Garraway, Levi A.

“…Monoclonal antibodies directed against cytotoxic T lymphocyte–associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for…”
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Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia by Landau, Dan A., Clement, Kendell, Ziller, Michael J., Boyle, Patrick, Fan, Jean, Gu, Hongcang, Stevenson, Kristen, Sougnez, Carrie, Wang, Lili, Li, Shuqiang, Kotliar, Dylan, Zhang, Wandi, Ghandi, Mahmoud, Garraway, Levi, Fernandes, Stacey M., Livak, Kenneth J., Gabriel, Stacey, Gnirke, Andreas, Lander, Eric S., Brown, Jennifer R., Neuberg, Donna, Kharchenko, Peter V., Hacohen, Nir, Getz, Gad, Meissner, Alexander, Wu, Catherine J.

“…Intratumoral heterogeneity plays a critical role in tumor evolution. To define the contribution of DNA methylation to heterogeneity within tumors, we performed…”
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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes by Shukla, Sachet A, Rooney, Michael S, Rajasagi, Mohini, Tiao, Grace, Dixon, Philip M, Lawrence, Michael S, Stevens, Jonathan, Lane, William J, Dellagatta, Jamie L, Steelman, Scott, Sougnez, Carrie, Cibulskis, Kristian, Kiezun, Adam, Hacohen, Nir, Brusic, Vladimir, Wu, Catherine J, Getz, Gad

“…An analysis of the HLA class I loci in 7,930 tumor samples detects recurrent mutation 'hotspots' in these genes. Detection of somatic mutations in human…”
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Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia: A Contemporary Perspective by Kwok, Marwan, Wu, Catherine J

“…Clonal evolution represents the natural process through which cancer cells continuously search for phenotypic advantages that enable them to develop and expand…”
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Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia by Rajasagi, Mohini, Shukla, Sachet A., Fritsch, Edward F., Keskin, Derin B., DeLuca, David, Carmona, Ellese, Zhang, Wandi, Sougnez, Carrie, Cibulskis, Kristian, Sidney, John, Stevenson, Kristen, Ritz, Jerome, Neuberg, Donna, Brusic, Vladimir, Gabriel, Stacey, Lander, Eric S., Getz, Gad, Hacohen, Nir, Wu, Catherine J.

“…Genome sequencing has revealed a large number of shared and personal somatic mutations across human cancers. In principle, any genetic alteration affecting a…”
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Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity by Backlund, Coralie M., Holden, Rebecca L., Moynihan, Kelly D., Garafola, Daniel, Farquhar, Charlotte, Mehta, Naveen K., Maiorino, Laura, Pham, Sydney, Iorgulescu, J. Bryan, Reardon, David A., Wu, Catherine J., Pentelute, Bradley L., Irvine, Darrell J.

“…Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest immunogenicity. One approach that has been explored to enhance peptide…”
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Enhancing CAR-T cell functionality in a patient-specific manner by Zhang, David K. Y., Adu-Berchie, Kwasi, Iyer, Siddharth, Liu, Yutong, Cieri, Nicoletta, Brockman, Joshua M., Neuberg, Donna, Wu, Catherine J., Mooney, David J.

“…Patient responses to autologous CD19 chimeric antigen receptor (CAR) T-cell therapies are limited by insufficient and inconsistent cellular functionality…”
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The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy by Landau, Dan A., Sun, Clare, Rosebrock, Daniel, Herman, Sarah E. M., Fein, Joshua, Sivina, Mariela, Underbayev, Chingiz, Liu, Delong, Hoellenriegel, Julia, Ravichandran, Sarangan, Farooqui, Mohammed Z. H., Zhang, Wandi, Cibulskis, Carrie, Zviran, Asaf, Neuberg, Donna S., Livitz, Dimitri, Bozic, Ivana, Leshchiner, Ignaty, Getz, Gad, Burger, Jan A., Wiestner, Adrian, Wu, Catherine J.

“…Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by…”
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DeTiN: overcoming tumor-in-normal contamination by Taylor-Weiner, Amaro, Stewart, Chip, Giordano, Thomas, Miller, Mendy, Rosenberg, Mara, Macbeth, Alyssa, Lennon, Niall, Rheinbay, Esther, Landau, Dan-Avi, Wu, Catherine J., Getz, Gad

“…Comparison of sequencing data from a tumor sample with data from a matched germline control is a key step for accurate detection of somatic mutations…”
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cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies by Pedersen, Christina Bligaard, Dam, Søren Helweg, Barnkob, Mike Bogetofte, Leipold, Michael D., Purroy, Noelia, Rassenti, Laura Z., Kipps, Thomas J., Nguyen, Jennifer, Lederer, James Arthur, Gohil, Satyen Harish, Wu, Catherine J., Olsen, Lars Rønn

“…Combining single-cell cytometry datasets increases the analytical flexibility and the statistical power of data analyses. However, in many cases the full…”
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A multicenter phase 1 study of nivolumab for relapsed hematologic malignancies after allogeneic transplantation by Davids, Matthew S., Kim, Haesook T., Costello, Caitlin, Herrera, Alex F., Locke, Frederick L., Maegawa, Rodrigo O., Savell, Alexandra, Mazzeo, Michael, Anderson, Adrienne, Boardman, Alexander P., Weber, Augustine, Avigan, David, Chen, Yi-Bin, Nikiforow, Sarah, Ho, Vincent T., Cutler, Corey, Alyea, Edwin P., Bachireddy, Pavan, Wu, Catherine J., Ritz, Jerome, Streicher, Howard, Ball, Edward D., Bashey, Asad, Soiffer, Robert J., Armand, Philippe

“…Programmed cell death-1 (PD-1)/programmed death ligand-1 blockade may potentially augment graft-vs-tumor effects following allogeneic hematopoietic cell…”
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irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial by Pignon, Jean-Christophe, Jegede, Opeyemi, Shukla, Sachet A, Braun, David A, Horak, Christine E, Wind-Rotolo, Megan, Ishii, Yuko, Catalano, Paul J, Grosha, Jonian, Flaifel, Abdallah, Novak, Jesse S, Mahoney, Kathleen M, Freeman, Gordon J, Sharpe, Arlene H, Hodi, F Stephen, Motzer, Robert J, Choueiri, Toni K, Wu, Catherine J, Atkins, Michael B, McDermott, David F, Signoretti, Sabina

“…Immune-related RECIST (irRECIST) were designed to capture atypical responses seen with immunotherapy. We hypothesized that, in patients with metastatic clear…”
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Allogeneic hematopoietic cell transplantation outcomes in patients with Richter's transformation by Kim, Haesook T, Baker, Peter O, Parry, Erin, Davids, Matthew, Alyea, Edwin P, Ho, Vincent T, Cutler, Corey, Koreth, John, Gooptu, Mahasweta, Romee, Rizwan, Nikiforow, Sarah, Antin, Joseph H, Ritz, Jerome, Soiffer, Robert J, Wu, Catherine J, Brown, Jennifer R

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Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics by Penter, Livius, Gohil, Satyen H, Wu, Catherine J

“…Blood malignancies provide unique opportunities for longitudinal tracking of disease evolution following therapeutic bottlenecks and for the monitoring of…”
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