Search Results - "Wu, Beverly P"

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations by Liu, Yi-Ting, Huang, Xiaoping, Nguyen, Diana, Shammas, Mario K, Wu, Beverly P, Dombi, Eszter, Springer, Danielle A, Poulton, Joanna, Sekine, Shiori, Narendra, Derek P

“…Abstract Dominant mutations in the mitochondrial paralogs coiled-helix-coiled-helix (CHCHD) domain 2 (C2) and CHCHD10 (C10) were recently identified as causing…”
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CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10 by Huang, Xiaoping, Wu, Beverly P, Nguyen, Diana, Liu, Yi-Ting, Marani, Melika, Hench, Jürgen, Bénit, Paule, Kozjak-Pavlovic, Vera, Rustin, Pierre, Frank, Stephan, Narendra, Derek P

“…Abstract Mutations in paralogous mitochondrial proteins CHCHD2 and CHCHD10 cause autosomal dominant Parkinson Disease (PD) and Amyotrophic Lateral…”
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OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy by Shammas, Mario K, Huang, Xiaoping, Wu, Beverly P, Fessler, Evelyn, Song, Insung, Randolph, Nicholas P, Li, Yan, Bleck, Christopher Ke, Springer, Danielle A, Fratter, Carl, Barbosa, Ines A, Powers, Andrew F, Quirós, Pedro M, Lopez-Otin, Carlos, Jae, Lucas T, Poulton, Joanna, Narendra, Derek P

“…Mitochondrial stress triggers a response in the cell's mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood…”
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Heterozygous PRKN mutations are common but do not increase the risk of Parkinson's disease by Zhu, William, Huang, Xiaoping, Yoon, Esther, Bandres-Ciga, Sara, Blauwendraat, Cornelis, Billingsley, Kimberly J, Cade, Joshua H, Wu, Beverly P, Williams, Victoria H, Schindler, Alice B, Brooks, Janet, Gibbs, J Raphael, Hernandez, Dena G, Ehrlich, Debra, Singleton, Andrew B, Narendra, Derek P

“…PRKN mutations are the most common recessive cause of Parkinson's disease and are a promising target for gene and cell replacement therapies. Identification of…”
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CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10 by Huang, Xiaoping, Wu, Beverly P, Nguyen, Diana, Liu, Yi-Ting, Marani, Melika, Hench, Jürgen, Bénit, Paule, Kozjak-Pavlovic, Vera, Rustin, Pierre, Frank, Stephan, Narendra, Derek P

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