Search Results - "Wrobleski, S. K."

Decrease in fibrin content of venous thrombi in selectin-deficient mice by Sullivan, V.V, Hawley, A.E, Farris, D.M, Knipp, B.S, Varga, A.J, Wrobleski, S.K, Thanapron, P, Eagleton, M.J, Myers, D.D, Fowlkes, J.B, Wakefield, T.W

“…The purpose of this study was to quantify the fibrin content of thrombi produced in a mouse model of venous thrombosis and correlate this to thrombus mass. The…”
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Inferior vena cava branch variations in C57BL/6 mice have an impact on thrombus size in an IVC ligation (stasis) model by Diaz, J. A., Farris, D. M., Wrobleski, S. K., Myers, D. D., Wakefield, T. W.

“…Summary Background Animal models of venous thrombosis (VT) are critical tools for those investigating the VT mechanism. Recently, inferior vena cava (IVC)…”
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Neovascularization during venous thrombosis organization: A preliminary study by Wakefield, Thomas W., Linn, Marisa J., Henke, Peter K., Kadell, Amy M., Wilke, Carol A., Wrobleski, Shirley K., Sarkar, Minakshi, Burdick, Marie D., Myers, Daniel D., Strieter, Robert M.

“…Purpose: Thrombus organization after venous thromboembolism leading to recanalization occurs at a variable rate. The angiogenic chemokine interleukin-8 (IL-8)…”
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Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects by Patterson, K.A, Zhang, X, Wrobleski, S.K, Hawley, A.E, Lawrence, D.A, Wakefield, T.W, Myers, D.D, Diaz, J.A

“…Abstract Introduction Statins, particularly rosuvastatin, have recently become relevant in the setting of venous thrombosis. The objective of this study was to…”
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P-selectin antagonism causes dose-dependent venous thrombosis inhibition by Myers, Jr, D D, Schaub, R, Wrobleski, S K, Londy, 3rd, F J, Fex, B A, Chapman, A M, Greenfield, L J, Wakefield, T W

“…Inhibition of P-selectin by antibody or selectin antagonist decreases inflammation and thrombosis. This study evaluates the dose-response relationship using a…”
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Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis by Downing, L.J., Wakefield, T.W., Strieter, R.M., Prince, M.R., Londy, F.J., Fowlkes, J.B., Hulin, M.S., Kadell, A.M., Wilke, C.A., Brown, S.L., Wrobleski, S.K., Burdick, M.D., Anderson, D.C., Greenfield, L.J.

“…Purpose: Venous thrombosis and inflammation are interrelated. P-selectin contributes to activation of leukocyte-mediated inflammation. Therefore, we…”
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Inflammatory and procoagulant mediator interactions in an experimental baboon model of venous thrombosis by Wakefield, T W, Greenfield, L J, Rolfe, M W, DeLucia, 3rd, A, Strieter, R M, Abrams, G D, Kunkel, S L, Esmon, C T, Wrobleski, S K, Kadell, A M

“…Theoretic and in vitro evidence suggests that thrombosis and inflammation are interrelated. The purpose of the present study was to define the relationship…”
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Venous Thrombosis-Associated Inflammation and Attenuation With Neutralizing Antibodies to Cytokines and Adhesion Molecules by Wakefield, Thomas W, Strieter, Robert M, Wilke, Carol A, Kadell, Amy M, Wrobleski, Shirley K, Burdick, Marie D, Schmidt, Regina, Kunkel, Steven L, Greenfield, Lazar J

“…Thrombosis and inflammation are closely related. However, the response of the vein wall to venous thrombosis has been poorly documented. This study examines…”
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Effects of differing rates of protamine reversal of heparin anticoagulation by Wakefield, Thomas W., Hantler, Charles B., Wrobleski, Shirley K., Crider, Bruce A., Stanley, James C.

“…Background. Protamine sulfate reversal of heparin anticoagulation may be associated with adverse cardiovascular side effects. The purpose of this study was to…”
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Ultrasound echogenicity in experimental venous thrombosis by Fowlkes, J B, Strieter, R M, Downing, L J, Brown, S L, Saluja, A, Salles-Cunha, S, Kadell, A M, Wrobleski, S K, Wakefield, T W

“…This study characterizes the echogenicity of experimentally induced venous thrombosis. Venous duplex imaging (Diasonics Spectra) was performed of the rat (n…”
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P-Selectin and TNF Inhibition Reduce Venous Thrombosis Inflammation by Wakefield, Thomas W., Strieter, Robert M., Downing, Lamiere J., Kadell, Amy M., Wilke, Carol A., Burdick, Marie D., Wrobleski, Shirley K., Phillips, M.Laurie, Paulson, James C., Anderson, Donald C., Greenfield, Lazar J.

“…Venous thrombosis induces a detrimental inflammatory response in the vein wall. The cytokine tumor necrosis factor-α (TNF) and the adhesion molecules,…”
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A novel protamine variant reversal of heparin anticoagulation in human blood in vitro by Hulin, Marc S., Wakefield, Thomas W., Andrews, Philip C., Wrobleski, Shirley K., Stoneham, Mark D., Doyle, Anthony R., Zelenock, Gerald B., Jacobs, Lloyd A., Shanley, Charles J., TenCate, Veronica M., Stanley, James C.

“…Purpose: Protamine reversal of heparin anticoagulation during cardiovascular surgery may cause severe hypotension and pulmonary hypertension. A novel protamine…”
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Neutrophils are the initial cell type identified in deep venous thrombosis induced vein wall inflammation by Downing, L J, Strieter, R M, Kadell, A M, Wilke, C A, Brown, S L, Wrobleski, S K, Burdick, M D, Hulin, M S, Fowlkes, J B, Greenfield, L J, Wakefield, T W

“…Venous thrombosis and inflammation are interrelated. The authors hypothesized that inferior vena cava thrombosis results in a predictable vein wall…”
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A [+18RGD] Protamine Variant for Nontoxic and Effective Reversal of Conventional Heparin and Low-Molecular- Weight Heparin Anticoagulation by Wakefield, Thomas W., Andrews, Philip C., Wrobleski, Shirley K., Kadell, Amy M., Tejwani, Samir, Hulin, Marc S., Stanley, James C.

“…Protamine sulfate reversal of heparin anticoagulation causes adverse side effects. Additionally, protamine sulfate is relatively ineffective at reversing…”
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Staging deep venous thrombosis using ultrasound elasticity imaging: animal model by Xie, Hua, Kim, Kang, Aglyamov, Salavat R, Emelianov, Stanislav Y, Chen, Xunchang, O'Donnell, Matthew, Weitzel, William F, Wrobleski, Shirley K, Myers, Daniel D, Wakefield, Thomas W, Rubin, Jonathan M

“…Deep venous thrombi undergo progressive hardening with age. However, the evolution rate remains poorly characterized by both invasive and noninvasive…”
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Venous thrombosis prophylaxis by inflammatory inhibition without anticoagulation therapy by Wakefield, Thomas W, Strieter, Robert M, Schaub, Robert, Myers, Daniel D, Prince, Martin R, Wrobleski, Shirley K, Londy, Frank J, Kadell, Amy M, Brown, Sandra L, Henke, Peter K, Greenfield, Lazar J

“…Objective: This study was performed to determine the effectiveness of recombinant P-selectin glycoprotein ligand Ig (rPSGL-Ig) pretreatment to decrease…”
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Heparin-mediated reductions of the toxic effects of protamine sulfate on rabbit myocardium by Wakefield, Thomas W., Wrobleski, Shirley K., Nichol, Brad J., Kadell, Amy M., Stanley, James C.

“…Protamine sulfate causes direct myocardial suppression when used to reverse heparin anticoagulation. Protamine's excessive positive charge accompanying its…”
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Reversal of low-molecular-weight heparin anticoagulation by synthetic protamine analogues by Wakefield, T W, Andrews, P C, Wrobleski, S K, Kadell, A M, Fazzalari, A, Nichol, B J, Vanderkooi, T, Stanley, J C

“…Protamine reversal of unfractionated and low-molecular-weight heparin (LMWH) causes hypotension, bradycardia, pulmonary artery hypertension, and declines in…”
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Deep venous thrombosis in the baboon: An experimental model by Wakefield, Thomas W., Wrobleski, Shirley K., Sarpa, Mary S., Taylor, Fletcher B., Esmon, Charles T., Cheng, Al, Greenfield, Lazar J.

“…Experimental models of deep venous thrombosis, heretofore, have not been available for laboratory studies. This investigation establishes a novel model of…”
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Increased prostacyclin and adverse hemodynamic responses to protamine sulfate in an experimental canine model by Wakefield, T W, Wrobleski, S K, Wirthlin, D J, Wang, T W, Stanley, J C

“…Prostanoid activity was correlated with the hemodynamic effects of protamine sulfate reversal of heparin in 24 dogs undergoing three different pretreatment…”
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