Search Results - "Wrighton, Christopher J"

Modification of vascular responses in xenotransplantation: Inflammation and apoptosis by Bach, Fritz H, Ferran, Christiane, Soares, Miguel, Wrighton, Christopher J, Anrather, Josef, Winkler, Hans, Robson, Simon C, Hancock, Wayne W

“…Interest in clinical xenotransplantation has increased markedly recently, despite a persisting debate regarding biochemical incompatibilities, risk of…”
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Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme by Race, Paul R, Lovering, Andrew L, Green, Richard M, Ossor, Abdelmijd, White, Scott A, Searle, Peter F, Wrighton, Christopher J, Hyde, Eva I

“…The antibiotics nitrofurazone and nitrofurantoin are used in the treatment of genitourinary infections and as topical antibacterial agents. Their action is…”
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Lipid-Heparin Infusion Suppresses the IL-10 Response to Trauma in Subcutaneous Adipose Tissue in Humans by Ikeoka, Dimas T., Pachler, Christoph, Mader, Julia K., Bock, Gerlies, Neves, Ana L., Svehlikova, Eva, Feichtner, Franz, Koehler, Gerd, Wrighton, Christopher J., Pieber, Thomas R., Ellmerer, Martin

“…An imbalance between pro‐ and anti‐inflammatory cytokine productions in adipose tissue is thought to contribute to chronic, systemic, low‐grade inflammation…”
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Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954 by GROVE, Jane I, LOVERING, Andrew L, GUISE, Christopher, RACE, Paul R, WRIGHTON, Christopher J, WHITE, Scott A, HYDE, Eva I, SEARLE, Peter F

“…Escherichia coli nitroreductase (NTR) activates the prodrug CB1954 to a cytotoxic derivative, allowing selective sensitization of NTR-expressing cells or…”
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Transcriptionally Targeted Nonviral Gene Transfer Using a β-Catenin/TCF-Dependent Promoter in a Series of Different Human Low Passage Colon Cancer Cells by Gaedtke, Lars, Pelisek, Jaroslav, Lipinski, Kai S, Wrighton, Christopher J, Wagner, Ernst

“…Nonviral transfections of six low passage human colon cancer cell lines using the artificial β-catenin/TCF-dependent promoter CTP4 demonstrated a high promoter…”
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An oncolytic adenovirus vector combining enhanced cell-to-cell spreading, mediated by the ADP cytolytic protein, with selective replication in cancer cells with deregulated Wnt signaling by TOTH, Karoly, DJEHA, Hakim, BAOLING YING, TOLLEFSON, Ann E, KUPPUSWAMY, Mohan, DORONIN, Konstantin, KRAJCSI, Peter, LIPINSKI, Kai, WRIGHTON, Christopher J, WOLD, William S. M

“…We have constructed a novel oncolytic adenovirus (Ad) vector named VRX-009 that combines enhanced cell spread with tumor-specific replication. Enhanced spread,…”
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Optimization of a Synthetic β-Catenin-Dependent Promoter for Tumor-specific Cancer Gene Therapy by Lipinski, Kai S, Djeha, Hakim A, Gawn, Jonathan, Cliffe, Suzanne, Maitland, Norman J, Palmer, Daniel H, Mountain, Andrew, Irvine, Alistair S, Wrighton, Christopher J

“…We recently published the construction and evaluation of a beta-catenin-dependent, highly active promoter, CTP1, and its possible application for the treatment…”
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Adenovirus-Mediated Expression of a Dominant Negative Mutant of p65/RelA Inhibits Proinflammatory Gene Expression in Endothelial Cells Without Sensitizing to Apoptosis by Soares, Miguel P, Muniappan, Ashok, Kaczmarek, Elzbieta, Koziak, Katarzyna, Wrighton, Christopher J, Steinhauslin, Florence, Ferran, Christiane, Winkler, Hans, Bach, Fritz H, Anrather, Josef

“…We hypothesized that blocking the induction of proinflammatory genes associated with endothelial cell (EC) activation, by inhibiting the transcription factor…”
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Combined Adenovirus-Mediated Nitroreductase Gene Delivery and CB1954 Treatment: A Well-Tolerated Therapy for Established Solid Tumors by Djeha, A.Hakim, Thomson, T.Andrew, Leung, Hing, Searle, Peter F., Young, Lawrence S., Kerr, David J., Harris, Peter A., Mountain, Andrew, Wrighton, Christopher J.

“…Gene-directed enzyme prodrug therapy (GDEPT) is a refinement of cancer chemotherapy that generates a potent cell-killing drug specifically in tumor cells by…”
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Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase CB1954 is enhanced by high-level coexpression of heat shock protein 70 by Djeha, Hakim A, Todryk, Stephen M, Pelech, Steven, Wrighton, Christopher J, Irvine, Alistair S, Mountain, Andrew, Lipinski, Kai S

“…Gene-directed enzyme prodrug therapy (GDEPT) is a promising approach to local management of cancer through targeted chemotherapy. Killing localized tumors by…”
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Structural and Mechanistic Studies of Escherichia coli Nitroreductase with the Antibiotic Nitrofurazone by Race, Paul R., Lovering, Andrew L., Green, Richard M., Ossor, Abdelmijd, White, Scott A., Searle, Peter F., Wrighton, Christopher J., Hyde, Eva I.

“…The antibiotics nitrofurazone and nitrofurantoin are used in the treatment of genitourinary infections and as topical antibacterial agents. Their action is…”
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Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954 by Djeha, A H, Hulme, A, Dexter, M T, Mountain, A, Young, L S, Searle, P F, Kerr, D J, Wrighton, C J

“…Expression of the Escherichia coli enzyme nitroreductase (NTR) in mammalian cells enables them to activate the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide…”
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EXPRESSION OF HUMAN THROMBOMODULIN COFACTOR ACTIVITY IN PORCINE ENDOTHELIAL CELLS1,2 by Kopp, Christoph W., Grey, Shane T., Siegel, Jonathan B., McShea, Andrew, Vetr, Helga, Wrighton, Christopher J., Schulte Esch, Jan, Bach, Fritz H., Robson, Simon C.

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A20 Inhibits NF-κB Activation in Endothelial Cells Without Sensitizing to Tumor Necrosis Factor–Mediated Apoptosis by Ferran, Christiane, Stroka, Deborah M., Badrichani, Anne Z., Cooper, Jeffrey T., Wrighton, Christopher J., Soares, Miguel, Grey, Shane T., Bach, Fritz H.

“…Expression of the NF-κB–dependent gene A20 in endothelial cells (EC) inhibits tumor necrosis factor (TNF)–mediated apoptosis in the presence of cycloheximide…”
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A20 Inhibits NF-κB Activation in Endothelial Cells Without Sensitizing to Tumor Necrosis Factor–Mediated Apoptosis by Ferran, Christiane, Stroka, Deborah M., Badrichani, Anne Z., Cooper, Jeffrey T., Wrighton, Christopher J., Soares, Miguel, Grey, Shane T., Bach, Fritz H.

“…Expression of the NF-κB–dependent gene A20 in endothelial cells (EC) inhibits tumor necrosis factor (TNF)–mediated apoptosis in the presence of cycloheximide…”
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Repressor titration: A novel system for selection and stable maintenance of recombinant plasmids by Williams, Steven G., Cranenburgh, Rocky M., Weiss, Amanda M.E., Wrighton, Christopher J., Hanak, Julian A.J., Sherratt, David J.

“…The propagation of recombinant plasmids in bacterial hosts, particularly in Escherichia coli, is essential for the amplification and manipulation of cloned DNA…”
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Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector‐mediated expression of E. coli nitroreductase by Weedon, Sarah J., Green, Nicola K., McNeish, Iain A., Gilligan, Moira G., Mautner, Vivien, Wrighton, Christopher J., Mountain, Andrew, Young, Lawrence S., Kerr, David J., Searle, Peter F.

“…The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5‐(aziridin‐1‐yl)‐2,4‐dinitrobenzamide (CB1954) to a potent…”
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Optimization of a Synthetic [beta]-Catenin-Dependent Promoter for Tumor-specific Cancer Gene Therapy by Lipinski, Kai S, Djeha, Hakim A, Gawn, Jonathan, Cliffe, Suzanne, Maitland, Norman J, Palmer, Daniel H, Mountain, Andrew, Irvine, Alistair S, Wrighton, Christopher J

“…We recently published the construction and evaluation of a β-catenin-dependent, highly active promoter, CTP1, and its possible application for the treatment of…”
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High-Level, β-Catenin/TCF-Dependent Transgene Expression in Secondary Colorectal Cancer Tissue by Lipinski, Kai S., Djeha, A.Hakim, Ismail, Tariq, Mountain, Andrew, Young, Lawrence S., Wrighton, Christopher J.

“…There is an urgent need for improved therapies for inoperable metastatic colon cancer. Genedirected enzyme prodrug therapy (GDEPT) using adenovirus vectors…”
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High-Level, [beta]-Catenin/TCF-Dependent Transgene Expression in Secondary Colorectal Cancer Tissue by Lipinski, Kai S, Djeha, A Hakim, Ismail, Tariq, Mountain, Andrew, Young, Lawrence S, Wrighton, Christopher J

“…There is an urgent need for improved therapies for inoperable metastatic colon cancer. Genedirected enzyme prodrug therapy (GDEPT) using adenovirus vectors…”
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