Search Results - "Wright, Woodring"

Telomeres and telomerase: three decades of progress by Shay, Jerry W., Wright, Woodring E.

“…Many recent advances have emerged in the telomere and telomerase fields. This Timeline article highlights the key advances that have expanded our views on the…”
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Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52 by Min, Jaewon, Wright, Woodring E, Shay, Jerry W

“…Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers. One of the hallmarks…”
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Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes by Min, Jaewon, Wright, Woodring E., Shay, Jerry W.

“…Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers. By analyzing…”
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Comparison of telomere length measurement methods by Lai, Tsung-Po, Wright, Woodring E., Shay, Jerry W.

“…The strengths and limitations of the major methods developed to measure telomere lengths (TLs) in cells and tissues are presented in this review. These include…”
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Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer by Kim, Wanil, Ludlow, Andrew T, Min, Jaewon, Robin, Jerome D, Stadler, Guido, Mender, Ilgen, Lai, Tsung-Po, Zhang, Ning, Wright, Woodring E, Shay, Jerry W

“…Telomerase is expressed in early human development and then becomes silenced in most normal tissues. Because ~90% of primary human tumors express telomerase…”
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Role of telomeres and telomerase in cancer by Shay, Jerry W, Wright, Woodring E

“…Abstract There is mounting evidence for the existence of an important relationship between telomeres and telomerase and cellular aging and cancer. Normal human…”
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Telomeropathies: An emerging spectrum disorder by Holohan, Brody, Wright, Woodring E, Shay, Jerry W

“…A constellation of related genetic diseases are caused by defects in the telomere maintenance machinery. These disorders, often referred to as telomeropathies,…”
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Telomeres and telomerase in normal and cancer stem cells by Shay, Jerry W., Wright, Woodring E.

“…Differences between normal adult tissue stem cells and cancer stem/initiating cells remain poorly defined. For example, it is controversial if cancer stem…”
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A method for measuring the distribution of the shortest telomeres in cells and tissues by Lai, Tsung-Po, Zhang, Ning, Noh, Jungsik, Mender, Ilgen, Tedone, Enzo, Huang, Ejun, Wright, Woodring E., Danuser, Gaudenz, Shay, Jerry W.

“…Improved methods to measure the shortest (not just average) telomere lengths (TLs) are needed. We developed Telomere Shortest Length Assay (TeSLA), a technique…”
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Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands by Min, Jaewon, Wright, Woodring E, Shay, Jerry W

“…Alternative lengthening of telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in ∼15% of cancers. The potential mechanism…”
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Telomerase therapeutics for cancer: challenges and new directions by Shay, Jerry W, Wright, Woodring E

“…It has been approximately a decade since telomerase was described as an almost universal marker for human cancer. Most human tumours not only express…”
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The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells by Bhagwandin, Vikash J, Bishop, J Michael, Wright, Woodring E, Shay, Jerry W

“…Cancer stem cells (CSCs) typically have the capacity to evade chemotherapy and may be the principal source of metastases. CSCs for human pancreatic ductal…”
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The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch by Lue, Neal F., Chan, Jamie, Wright, Woodring E., Hurwitz, Jerard

“…Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate primase-Pol α (PP) activity at telomeres constitutively,…”
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Cancer and Telomeres—An ALTernative to Telomerase by Shay, Jerry W., Reddel, Roger R., Wright, Woodring E.

“…Finding ways to target the alternative (ALT) telomere lengthening pathway found in some cancer cells could complement telomerase inhibitors currently in…”
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Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine by Mender, Ilgen, Gryaznov, Sergei, Dikmen, Z Gunnur, Wright, Woodring E, Shay, Jerry W

“…The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue…”
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Cancer. Cancer and telomeres--an ALTernative to telomerase by Shay, Jerry W, Reddel, Roger R, Wright, Woodring E

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Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances by Robin, Jérôme D, Ludlow, Andrew T, Batten, Kimberly, Magdinier, Frédérique, Stadler, Guido, Wagner, Kathyrin R, Shay, Jerry W, Wright, Woodring E

“…While global chromatin conformation studies are emerging, very little is known about the chromatin conformation of human telomeres. Most studies have focused…”
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Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In by Wang, Feng, Stewart, Jason A., Kasbek, Christopher, Zhao, Yong, Wright, Woodring E., Price, Carolyn M.

“…Human CST (CTC1-STN1-TEN1) is an RPA-like complex that is needed for efficient replication through the telomere duplex and genome-wide replication restart…”
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Alternative splicing regulation of telomerase: a new paradigm? by Wong, Mandy S, Wright, Woodring E, Shay, Jerry W

“…Highlights • Regulation of alternative splicing in abundant housekeeping genes is well studied. • Low-abundance gene regulation, including splicing, is…”
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Comparison of DNA Quantification Methods for Next Generation Sequencing by Robin, Jérôme D., Ludlow, Andrew T., LaRanger, Ryan, Wright, Woodring E., Shay, Jerry W.

“…Next Generation Sequencing (NGS) is a powerful tool that depends on loading a precise amount of DNA onto a flowcell. NGS strategies have expanded our ability…”
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