Search Results - "Wright, William C"

Drivers of heritage value: A meta-analysis of monetary valuation studies of cultural heritage by Wright, William C.C., Eppink, Florian V.

“…Decisions about cultural and historical heritage conservation can be contentious. Improved insight into the economic benefits derived from preservation could…”
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Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery by Lolodi, Ogheneochukome, Wang, Yue-Ming, Wright, William C, Chen, Taosheng

“…Cancer cells use several mechanisms to resist the cytotoxic effects of drugs, resulting in tumor progression and invasion. One such mechanism capitalizes on…”
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Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70 by Li, Yongtao, Lin, Wenwei, Wright, William C, Chai, Sergio C, Wu, Jing, Chen, Taosheng

“…Pregnane X receptor (PXR) plays roles in detoxification and other physiological processes. PXR activation may enhance drug metabolism (leading to adverse drug…”
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Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning by Huber, Andrew D., Wright, William C., Lin, Wenwei, Majumder, Kinjal, Low, Jonathan A., Wu, Jing, Buchman, Cameron D., Pintel, David J., Chen, Taosheng

“…Pregnane X receptor (PXR) is activated by chemicals to transcriptionally regulate drug disposition and possibly decrease drug efficacy and increase resistance,…”
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The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma by Pan, Min, Wright, William C., Chapple, Richard H., Zubair, Asif, Sandhu, Manbir, Batchelder, Jake E., Huddle, Brandt C., Low, Jonathan, Blankenship, Kaley B., Wang, Yingzhe, Gordon, Brittney, Archer, Payton, Brady, Samuel W., Natarajan, Sivaraman, Posgai, Matthew J., Schuetz, John, Miller, Darcie, Kalathur, Ravi, Chen, Siquan, Connelly, Jon Patrick, Babu, M. Madan, Dyer, Michael A., Pruett-Miller, Shondra M., Freeman, Burgess B., Chen, Taosheng, Godley, Lucy A., Blanchard, Scott C., Stewart, Elizabeth, Easton, John, Geeleher, Paul

“…Survival in high-risk pediatric neuroblastoma has remained around 50% for the last 20 years, with immunotherapies and targeted therapies having had minimal…”
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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5 by Wright, William C, Chenge, Jude, Wang, Jingheng, Girvan, Hazel M, Yang, Lei, Chai, Sergio C, Huber, Andrew D, Wu, Jing, Oladimeji, Peter O, Munro, Andrew W, Chen, Taosheng

“…The human cytochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metabolize most drugs and have high similarities in their structure and substrate preference. Whereas…”
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A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics by Lee, Hyeong-Min, Wright, William C., Pan, Min, Low, Jonathan, Currier, Duane, Fang, Jie, Singh, Shivendra, Nance, Stephanie, Delahunty, Ian, Kim, Yuna, Chapple, Richard H., Zhang, Yinwen, Liu, Xueying, Steele, Jacob A., Qi, Jun, Pruett-Miller, Shondra M., Easton, John, Chen, Taosheng, Yang, Jun, Durbin, Adam D., Geeleher, Paul

“…Combination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and…”
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An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs by Chapple, Richard H, Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I M, Kim, Yuna, Patel, Anand G, LaFlamme, Christy W, Pan, Min, Wright, William C, Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C, Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D, Confer, Thomas, Akers, Walter J, Dyer, Michael A, Sheppard, Heather, Easton, John, Geeleher, Paul

“…Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy…”
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Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia by Kamens, Jennifer L., Nance, Stephanie, Koss, Cary, Xu, Beisi, Cotton, Anitria, Lam, Jeannie W., Garfinkle, Elizabeth A. R., Nallagatla, Pratima, Smith, Amelia M. R., Mitchell, Sharnise, Ma, Jing, Currier, Duane, Wright, William C., Kavdia, Kanisha, Pagala, Vishwajeeth R., Kim, Wonil, Wallace, LaShanale M., Cho, Ji-Hoon, Fan, Yiping, Seth, Aman, Twarog, Nathaniel, Choi, John K., Obeng, Esther A., Hatley, Mark E., Metzger, Monika L., Inaba, Hiroto, Jeha, Sima, Rubnitz, Jeffrey E., Peng, Junmin, Chen, Taosheng, Shelat, Anang A., Guy, R. Kiplin, Gruber, Tanja A.

“…Rearrangments in Histone-lysine-N-methyltransferase 2A (KMT2Ar) are associated with pediatric, adult and therapy-induced acute leukemias. Infants with KMT2Ar…”
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Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells by Bakke, Jesse, Wright, William C, Zamora, Anthony E, Oladimeji, Peter, Crawford, Jeremy Chase, Brewer, Christopher T, Autry, Robert J, Evans, William E, Thomas, Paul G, Chen, Taosheng

“…Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis…”
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CINPA1 binds directly to constitutive androstane receptor and inhibits its activity by Cherian, Milu T., Chai, Sergio C., Wright, William C., Singh, Aman, Alexandra Casal, Morgan, Zheng, Jie, Wu, Jing, Lee, Richard E., Griffin, Patrick R., Chen, Taosheng

“…[Display omitted] The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that regulate the expression of…”
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Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia by Kamens, Jennifer L., Nance, Stephanie, Koss, Cary, Xu, Beisi, Cotton, Anitria, Lam, Jeannie W., Garfinkle, Elizabeth A. R., Nallagatla, Pratima, Smith, Amelia M. R., Mitchell, Sharnise, Ma, Jing, Currier, Duane, Wright, William C., Kavdia, Kanisha, Pagala, Vishwajeeth R., Kim, Wonil, Wallace, LaShanale M., Cho, Ji-Hoon, Fan, Yiping, Seth, Aman, Twarog, Nathaniel, Choi, John K., Obeng, Esther A., Hatley, Mark E., Metzger, Monika L., Inaba, Hiroto, Jeha, Sima, Rubnitz, Jeffrey E., Peng, Junmin, Chen, Taosheng, Shelat, Anang A., Guy, R. Kiplin, Gruber, Tanja A.

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Structural perspectives of the CYP3A family and their small molecule modulators in drug metabolism by Wright, William C., Chenge, Jude, Chen, Taosheng

“…Cytochrome P450 (CYP) enzymes function to catalyze a wide range of reactions, many of which are critically important for drug response. Members of the human…”
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CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer by Shao, Ming, Pan, Qingfei, Tan, Haiyan, Wu, Jing, Lee, Ha Won, Huber, Andrew D., Wright, William C., Cho, Ji-Hoon, Yu, Jiyang, Peng, Junmin, Chen, Taosheng

“…CYP3A5 is a cytochrome P450 (CYP) enzyme that metabolizes drugs and contributes to drug resistance in cancer. However, it remains unclear whether CYP3A5…”
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Transcription factor ZNF148 is a negative regulator of human muscle differentiation by Bakke, Jesse, Wright, William C., Zamora, Anthony E., Ong, Su Sien, Wang, Yue-Ming, Hoyer, Jessica D., Brewer, Christopher T., Thomas, Paul G., Chen, Taosheng

“…Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily…”
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Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer by Chai, Sergio C., Wright, William C., Chen, Taosheng

“…Pregnane X receptor (PXR) is a ligand‐activated nuclear receptor (NR) that was originally identified as a master regulator of xenobiotic detoxification. It…”
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RNA interference screen identifies NAA10 as a regulator of PXR transcription by Oladimeji, Peter O., Wright, William C., Wu, Jing, Chen, Taosheng

“…[Display omitted] The pregnane X receptor (PXR) is a principal xenobiotic receptor crucial in the detection, detoxification, and clearance of toxic substances…”
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KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion by Oladimeji, Peter O., Bakke, Jesse, Wright, William C., Chen, Taosheng

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. One major reason for this is that PDAC quickly metastasizes to other organs,…”
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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation by Bwayi, Monicah N, Garcia-Maldonado, Efren, Chai, Sergio C, Xie, Boer, Chodankar, Shirish, Huber, Andrew D, Wu, Jing, Annu, Kavya, Wright, William C, Lee, Hyeong-Min, Seetharaman, Jayaraman, Wang, Jingheng, Buchman, Cameron D, Peng, Junmin, Chen, Taosheng

“…Abstract The 48 human nuclear receptors (NRs) form a superfamily of transcription factors that regulate major physiological and pathological processes…”
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Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5 by Wang, Jingheng, Buchman, Cameron D, Seetharaman, Jayaraman, Miller, Darcie J, Huber, Andrew D, Wu, Jing, Chai, Sergio C, Garcia-Maldonado, Efren, Wright, William C, Chenge, Jude, Chen, Taosheng

“…The human cytochrome P450 (CYP) CYP3A4 and CYP3A5 enzymes metabolize more than one-half of marketed drugs. They share high structural and substrate similarity…”
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